OBJECTIVE: The purpose of this study is to investigate the effective of alternating Chemo-radiotherapy for locally Advanced Nasopharyngeal Carcinoma. METHOD: Retrospective analysis 106 cases of patients with locally advanced nasopharyngeal carcinoma between November 2005 and March 2007. All patients received cisplatin-based chemotherapy but 15 patients received radiotherapy(RT) alone. Inducing chemotherapy (IC) + RT + adju-vant chemotherapy (AC) regimen in 36 patients, IC+RT regimen was delivered in 25 patients and AC + RT regimen in 30 patients. 61 patients received 1 to 2 cycles of inducing chemotherapy and 66 patients received 3 to 6 cycles of adjuvant chemotherapy after radiotherapy. Chemotherapy started on the first day after the end of the induction chemotherapy, adjuvant chemotherapy begun after radiotherapy for a week. All patients were treated by radiotherapy using 60 Co r-ray, the nasophyarynx primary site was given a total does of 68 -74 Gy. The lymph nodes of the neck was given 60 to 70 Gy. The prophylactic irradiation does of the neck was 48-50 Gy. RESCULT: The median follow up time was 51 months. A total of 58 patients died, the overall survival rate was 45% in whole groups. The 5-year overall survival rates were 33%, 63%, 60% and 50% in RT, IC + RT + AC, IC + RT and RT+AC group, respectively. The 5-year disease-free survival rates were 13%, 56%, 48% and 40% in RT, IC + RT + AC, IC + RT and RT + AC group, respectively. The 5-year relapse-free survival rates were 13%, 53%, 48% and 50% in RT, IC + RT + AC, IC + RT and RT + AC group, respectively. The 5-year metastasis-free survival rates were 6%, 50%, 44% and 47% in RT, IC + RT + AC, IC+ RT and RT + AC group, respectively. There was significant difference in all groups (P < 0.05). The median time to relapses were 22 months, 29 months, 28 months and 25 months in RT, IC + RT + AC, IC + RT and RT + AC group, respectively. The median time to first distant metastasis were 10 months, 19 months, 15 months and 12 months in RT, IC + RT + AC, IC + RT and RT + AC group, respectively. There was no significant difference in all groups (P > 0.05). IC + RT + AC group had heavier acute toxicity effects than other groups, but it did not affect the treatment process, all patients could be tolerated. CONCLUSION This retrospective study has demonstrated that alternating Chemo-radiotherapy and early radiotherapy not only can improve the survival rate for locally Advanced Nasopharyngeal Carcinoma, but also have slight toxicities and side reaction, all patients may tolerated.
Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Carcinoma ; Chemotherapy, Adjuvant ; adverse effects ; Cisplatin ; administration & dosage ; Disease-Free Survival ; Female ; Humans ; Induction Chemotherapy ; adverse effects ; Male ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms ; drug therapy ; mortality ; pathology ; radiotherapy ; Neoplasm Staging ; Radiotherapy Dosage ; Retrospective Studies ; Survival Rate ; Treatment Outcome

Carcinoma ; Cytological Techniques ; Humans ; Nasopharyngeal Neoplasms ; pathology ; Neoplastic Stem Cells ; cytology ; Oncogenes

Chronic Periodontitis ; diagnosis ; diagnostic imaging ; therapy ; Dental Scaling ; Follow-Up Studies ; Furcation Defects ; diagnosis ; diagnostic imaging ; therapy ; Gingival Hyperplasia ; diagnosis ; diagnostic imaging ; therapy ; Humans ; Male ; Middle Aged ; Periodontal Index ; Radiography, Panoramic ; Root Canal Therapy ; Tooth Loss ; diagnosis ; diagnostic imaging ; therapy ; Tooth, Artificial

Brain ; growth & development ; Child Development ; Humans ; Infant Behavior ; Infant, Newborn ; physiology ; Motor Activity ; Neonatal Screening ; Nerve Net ; Neurologic Examination

OBJECTIVETo compare the difference in the clinical efficacy on post-stroke insomnia between the low-frequency electric stimulation at the acupoints and the conventional western medication.

METHODSOne hundred and twenty patients of post-stroke insomnia were randomized into a low-frequency electric stimulation group, a medication group and a placebo group, 40 cases in each one. In the low-frequency electric stimulation group, the low-frequency electric-pulsing apparatus was used at Dazhui (GV 14) and Shenshu (BL 23), once a day; the treatment of 15 days made one session and 2 sessions were required. In the medication group, estazolam was taken orally, 1 mg each time. In the placebo group, starch capsules were taken orally, 1 capsule each time. All the drugs were taken before sleep every night, continuously for 15 days as one session, and 2 sessions were required. PSQI changes and clinical efficacy were observed before and after treatment in each group.

RESULTSPitlsburgh sleep quality index (PSQI) score was reduced in every group after treatment (all P < 0.01). In the low-frequency electric stimulation group and medication group, the score was reduced much more significantly as compared with the placebo group (both P < 0.01). In the placebo group, 1 case was rejected. The total effective rates were 95.0% (38/40), 92.5% (37/40) and 17.9% (7/39) in the low-frequency electric stimulation group, medication group and placebo group separately. The efficacy in the low-frequency electric stimulation group and medication group was better apparently than that in the placebo group (both P < 0.01).

CONCLUSIONThe low-frequency electric stimulation at the acupoints effectively and safely treats post-stroke insomnia and the efficacy of it is similar to that of estazolam.

Acupuncture Points ; Aged ; Aged, 80 and over ; Electric Stimulation ; Female ; Humans ; Male ; Middle Aged ; Sleep Initiation and Maintenance Disorders ; etiology ; therapy ; Stroke ; complications ; Treatment Outcome

Many methods can by used for the quantitative determination of the three types of immu-noglobulin. On the basis of the single radial immuno-diffusion method used by John L. Fahey,certain modifications have been made on the methods of diluting standard solutions and theirconcentrations, and the standard concentration of the immunoglobulins and the antibody-con-taining agar diffusion plates. In order to find the optimum condition of cultivation, theeffects of various temperatures and various cultivation time given by G. Mancini et al havebeen checked, and satisfactory standard curves have been obtained. Therefore, the accuracyof the analytical results is guaranteed. According to the results obtained, there is no observable effect on the diameter of theprecipitating ring when the temperature in culture-box is 35?C to 40?C and the cultivationtime extends to 96 hrs.

In this article, the projects in drug metabolism and pharmacokinetics funded by NSFC during "10th Five Year Plan" (2001~2005) in China were reviewed. The major research fields of these projects in drug metabolism and pharmacokinetics funded by NSFC during the financial years were overviewed and analyzed. Finally, current problems in these research fields in China were also briefly analyzed.

0.05). ?-EP level of psoriatic patients 1 and normal controls 1 was significantly higher than that of psoriatic patients 2 and normal controls 2 respectively (P0.05) . Conclusion It suggests that there is the correlation between serum ?-EP level and psychological factors. ?-EP is likely to participate in adjusting the whole body state, which provides the foundation for psychologic treatment.

Objective To elucidate the characteristics of dermatosis in air force pilots and to improve its prevention and treatment scientifically. Method We carried out an investigation on 288 air force pilots hospitalized for dermatosis over the past 20 years. Results The results showed that 57.99% of the patients studied were admitted to hospital due to psychoimmunodermatosis, with high person-time (61.39%) and significantly longer average hospitalization time than that of the patients with the other two kinds of dermatoses. With improvement in flight skill and intensity as well as prolongation of flight time, the incidence and number of relapse of psychoimmunodermatosis in pilots were correspondingly increased. Conclusion The results indicate that among various dermatoses, psychoimmunodermatosis should become the focus of prevention and treatment as far as air force pilots are concerned. Besides drug treatment, we should also put emphasis on health education and psychological persuasion.

Objective To investigate the changes of serum pituitary hormones and thyroid hormones in patients with severe brain injuries during hypothermia therapy. Methods Ninety-eight patients with severe brain injuries were randomly divided into mild hypothermia group (50 cases) and control group (routine therapy group,48 cases). The levels of serum PRL,TSH,FT 3 and FT 4 of patients in the both groups were detected by two-side sandwich immunological autochemoluminescence detection system before and after treatment. The therapeutic effects were observed and compared. Results After treatment,the levels of serum PRL,TSH and FT 4 of patients in hypothermia group were (0.25? 0.02) nmol/L ,(0.7?0.2) mU/L and (15.0?5.3) pmol/L,respectively,which were significantly lower than that in control group,ie,(0.46?0.04) nmol/L,(1.1?0.3) mU/L and (21.2? 6.4) pmol/L ,respectively. The good recovery rate (62%) in hypothermia group was higher than that of control group (35%) but the death rate (22%) in hypothermia group was lower than that of control group (42%). Conclusions Mild hypothermia can inhibit the rise of serum pituitary hormones and thyroid hormones after severe brain injury and improve the therapeutic effects.