Atrial tumor myocytes (AT-1 cells) were derived from tumor-bearing mice in which SV40 T large antigen drives atrial natriuretic promoter. AT-1 cells possess many features typically seen in cardiac cells from other species, such as spontaneous beating, multiple ion channels and responses to drugs, etc. Major ion channels are present in AT-1 cells: sodium, calcium and potassium channels. Sodium channel in AT-1 cells is highly sensitive to blocker tetrodotoxin. L- and T-type calcium channels respond to classical blockers. An important outward potassium current in AT-1 cells is the rapidly-activating delayed rectifier (IKr). IKr Is the sole time-dependently repolarizing potassium current in AT-1 cells. AT-1 cells are a very useful tool for studies in cardiac electrophysiology and pharmacology. As yet, a great number of cardiac and non-cardiac drugs have been tested for their IKr blocking actions in AT-1 cells. The polymorphic ventricular arrhythmia (torsade de pointes) is a severe side effect of IKr blockers.

Objective To compare of pregnancy induced hypertension caused postpartum hemorrhage by two treatment methods. Methods 104 patients with pregnancy induced hypertension were randomly divided into misopr-ostol plus oxytecin group ( observation group)54 cases and the control group ( 50 eases ), used oxytcoin alone, respec-tively, Results postpartum hemorrhage in The observation group of is five cases(9.2% )which was significantly low-er than the control group of 11 cases(22.0% ) ( X2= 3.95 ,P<0.05 ). average postparttun hemorrhage in observation group is ( 195.6±88.4) ml which was significantly lower than the control group (303.2±111.6) ml (t=2.31, P<0.05). Conclusion Misoprostol combined with oxytocin is effective, safe and convenient to patients with postpartum hemorrhage caused by pregnancy induced hypertension.

Objective To evaluate the efficacy of recombinant tissue-type plasminogen activator(rt-PA)and mild hypothermia for acute cerebral infarctions. Methods72 patients consistent with the inclusion criteria were randomly divided into 2 groups,hypothermia group receivied rt-PA combined with mild hypothermia and control group receiving rt-PA only.Neurological functions was evaluated with European Stroke Scale(ESS). ResultsAs intravenous thrombolytic therapy within 6h after the onset,the ESS scores examined 3 days after thrombolysis in hypothermia group was significantly higher than those in control group.As intravenous thrombolytic therapy during 6h to 12h after the onset,the ESS scores of hypothermia group increased more significantly from 24h after thrombolysis than those in control group. Conclusionft-PA combined with mild hypothermia was more effective than rT-PA only for acute cerebral infarctions,which was effective and relatively safe in the treatment of acute ischemic cerebral vascular disease.

Objective:To study the influence of cusp inclination of artificial posterior teeth on abutment displacement of unilateral distal-extension telescope crown denture.Methods:Study models of mandibular unilateral distal-extension and telescope crown dentures with the cusp inclination of 0?,12?,25? and 33? were respectively prepared. When food chip was masticated on the occlusal surface and the dentures were loaded by 29.4 N, 49 N or 68.6 N, the abutment displacement was measured.Then the data were calculated and reciprocally compared with statistical analyses. Results:Between anatomic and 25? semi-anatomic artificial posterior teeth, there were significant differences in the buccolingual and vertical abutment movement(P0.05). The parallel, inclination, twist-like and vertical movement of abutment increased with the increase of the load on the denture. The difference among different level of load was statistically significant (P

The accelerating pace of exchanges and cooperation in medical field between China and foreign countries demands a large number of medical papers, medical-related materials to be ac-curately translated into multiple languages , especially between English and Chinese . Oriented at English majors (medicine directed), based on eco-translatory approach and student-centered teaching method by creating simulations of the medical English ecological translation environment, this paper provided a better and effective practice-based teaching idea, which can promote students' medical English translation competence and strategies, even cultural consciousness and pragmatic ability in a comprehensive manner.

It is well established that type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease.Controversial data exist regarding the differential control of the immune system in TI DM.Recent studies have demonstrated that MicroRNAs (miRNAs),single-stranded noncoding RNAs,may play a key role in regulation of gene expression in the immune system.Dicer enzymes or abnormal miRNAs may lead to autoimmune reactions,and thus is expected to become a target for early diagnosis and treatment of T1DM in the future.This article reviews the correlations of known miRNAs with the immune regulation in T1DM and the research progression.

OBJECTIVE: The research is aimed at investigating the developing rule and the relationship between syndrome differentiation in traditional Chinese medicine (TCM) and clinical factors of gastric cancer, so that it can be helpful to the clinical work and indicating the prognosis. METHODS: We collected the medical records and the information of four diagnostic methods of 325 cases of gastric cancer sufferers in the way of clinical epidemiological survey, and divided them into 6 syndromes including dysfunction of spleen, disharmony of liver and stomach, blood stagnation in stomach, yin deficiency of stomach, phlegm dampness stagnation and deficiency of both qi and blood. Then we used univariate analysis of variance, rank sum test and chi square test to analyse the relationship between syndrome differentiation and clinical-related factors such as age, gender, Karnofsky score and clinical stage, etc. RESULTS: The syndrome of dysfunction of spleen plays the primary role in the disease. Disharmony of liver and stomach always happens in early stage of stomach cancer, usually more often in radical operation cases and less in metastasis ones. It also has a high proportion in female. Phlegm dampness stagnation and blood stagnation in stomach usually can be seen in middle or advanced stage of the disease, which have lower Karnofsky score. Deficiency of both qi and blood is the syndrome of stomach cancer in advanced stage, which results in lower living quality, and with high rate of relapse and metastasis. Syndrome of yin deficiency of stomach has lower proportion in stomach cancer cases, and the clinical-related factors have low influence on it. CONCLUSION: Syndrome in TCM of gastric cancer is relevant to some clinical factors and varies in progress.

OBJECTIVE: The research is aimed at investigating the developing rule and the relationship between syndrome differentiation in traditional Chinese Medicine (TCM) and clinical factors of gastric cancer so as to guide clinical work and indicate prognosis. METHODS: We collected the medical records and the information of four diagnostic methods of 325 cases of gastric cancer sufferers in the way of clinical epidemiological survey, and divided them into 6 syndromes including dysfunction of spleen, disharmony of liver and stomach, blood stagnation in stomach, yin deficiency of stomach, phlegm dampness stagnation and deficiency of both qi and blood. Then we used logistic regression analysis to analyze the relationship between syndrome differentiation and clinical-related factors such as age, gender, Karnofsky score and clinical stage, etc. RESULTS: The syndrome spleen dysfunction is a dominant one among the syndromes of stomach cancer. Disharmony of liver and stomach always happens in early stage of stomach cancer and is frequently seen in women. Patients with syndrome of phlegm dampness stagnation or deficiency of both qi and blood have lower Karnofsky score and poorer living quality. Syndromes of blood stagnation in stomach and yin deficiency of stomach show no relationship with the clinical factors in this research. CONCLUSION: Syndrome differentiation in TCM of gastric cancer is related to some clinical factors to a certain extent.

This study was aimed to explore the nonlinear relationship between syndromes and prescriptions by using the artificial neural network (ANN) algorithm. The clauses composed of syndromes and prescriptions in Shanghan Lun (Treatise on Cold Damage and Miscellaneous Diseases) were sorted out. A total of 245 clauses were trained with ANN to establish the knowledge base model of syndromes and prescriptions. After that, 100 clauses were tested. And then, the symptoms of Gui-Zhi-Tang (GZT) syndrome, Ma-Huang-Tang (MHT) syndrome, Xiao-Chai-Hu-Tang (XCHT) syndrome and Bai-Hu-Tang (BHT) syndrome were input into the model to predict the Chinese herbs. The results showed that the test accuracy of the model was 79%. For the herbs to GZT and MHT syndrome, the test error was less than 0.1. For the main herbs to XCHT and BHT syndrome, the test error was less than 0.1. While for other herbs, the test error was less than 0.3. It was concluded that the ANN algorithm can simulate the nonlinear relationship between syndromes and prescriptions, which can be applied to study the syndrome differentiation, in order to contribute to the syndromes and prescriptions standardization and the traditional Chinese medicine (TCM) information.

The emphasis and basic target of medical education is to cultivate medical students with high qualities. The qualities of medical students include professional ethics, self-cultivation, medical knowledge and physical-psychological quality, which is critical to the medical education. It has been proven that the teaching of Clinical Pathway is one of the most important factors to promote the improvement of comprehensive qualities of medical students.