The theory of planned behavior is used to study physician's behavior of clinical pathway compliance,on which the model of decision making mechanism for such compliance was built.This aims at exploring the relationship between the behavioral risk factors,behavioral belief and behavioral intention, and the occurrence,and recommend on further regulation of physicians'behavior and policies in hospital management.

By searching relevant data from the PubMed database, Chinese National Knowledge Infrastructure (CNKI) database and Wanfang database, a comprehensive analysis and review regarding acupuncture for cerebral ischemia reperfusion injury (CIRI) in recent 10 years were performed. The results showed that acupuncture could inhibit the inflammatory reaction, reduce oxidative stress injury, restrain brain edema formation, inhibit apoptosis, promote neural and vascular regeneration, etc. Acupuncture methods used included electroacupuncture, scalp acupuncture, eye acupuncture and "consciousness-restoring resuscitation needling", etc. The existing problem was that the intervention action of acupuncture was mainly focused on inhibiting inflammatory reaction and oxidative stress injury, and the study on apoptosis and neural and vascular regeneration was needed. It is suggested that from the aspect of multiple target points, the intervention mechanism of acupuncture for CIRI should be systemically studied in the future, which could provide new idea for clinical diagnosis and treatment on ischemic cerebrovascular diseases.
Acupuncture Therapy ; history ; Animals ; Apoptosis ; Brain Ischemia ; history ; surgery ; History, 21st Century ; Humans ; Oxidative Stress ; PubMed ; Reperfusion Injury ; etiology ; history ; physiopathology ; therapy

Objective: To study the effect of down-regulation of eukaryotic translation initiation factor 4E (EIF 4E ) induced by the siRNA expression plasmid on the proliferation and cell cycle of human breast cancer cell line MDA-MB-231. Methods: The siRNA expression plasmid pGPU6/GFP/Neo-EIF4E was constructed and then transfected into breast cancer MDA-MB-231 cells by LipofectAMINE2000. The expressions of EIF4E and cyclin D1 mRNAs and proteins were examined by RT-PCR, Western blotting and the immunocytochemistry method, respectively. The MTT method, plate colony formation assay and flow cytometry were performed to detect the proliferation ability, cell colony formation rate and cell cycle distribution of MDA-MB-231 cells transfected with siRNA expression plasmid. Results: The siRNA expression plasmid pGPU6/GFP/Neo-EIF4E was constructed successfully. The expressions of EIF4E and cyclin D1 mRNAs and proteins were all decreased markedly after transfection with pGPU6/GFP/Neo-EIF4E (P <0.05). The growth of MDA-MB-231 cells in the pGPU6/GFP/Neo-EIF4E-tranfected group was inhibited and the cell colony formation rate was statistically decreased (P<0.05) as compared with those in the blank control and the pGPU6/GFP-transfected groups. The result of flow cytometry showed that the percentage of cells in G1 phase in the pGPU6/GFP/Neo-EIF4E-tranfected group was higher than that in the blank control group (71.30%±0.47% vs 53.10%±0.43%); however, the percentage of cells in S phase was signifcantly lower (12.53%±0.13% vs 26.47%±0.38%, P <0.05). Conclusion: EIF 4E siRNA can downregulate EIF 4E gene expression in human breast cancer MDA-MB-231 cells, suppress cell proliferation to some extent, and increase the number of cells in G1 phase with a decreased number of cells in S phase. EIF 4E gene may become one of the important molecular targets to breast cancer. Copyright© 2011 by the Editorial Board of Tumor.

Adolescent ; Child ; Epidural Abscess ; diagnosis ; surgery ; Female ; Humans ; Male ; Spinal Diseases ; diagnosis ; surgery

Such management theories as social exchange, equity and incentives are called into play to probe, from an array of perspectives, into the functionality and role of the employee orientation in people-oriented concept as it is used in contemporary hospital management. The paper also analyzed the dialectical relationship between the concept of "employee-orientation" and that of "patients or customers orientation", and the dialectical relationship between "people-orientation" model and "policy-orientation" model It pinpoints the mistake of overemphasizing "patients or customer orientation" and neglecting employee management in hospital management, proposing a people-oriented path centering on employees in hospital management.

Objective Retrospective analysis of 56 cases of the surgical humerus neck of children that treated with abduction brace combined with manipulative reduction,and discuss the significance of abduction brace combined with manipulative reduction in treatment of fracture of the surgical humerus neck about children.Methods This study consisted of 56 children with fracture of the surgical humerus neck,among these,41 were males and 15 were females,9 were road accident and 47 were falling injury,average 7.67 years.They were all treated with abduction brace combined with manipulative reduction,after 1 month fixation,dismantled the abduction brace and did the functional exercise.Results Follow-up study was carried out in 56 cases,followed 6 months to 5 years,average 2.96 years,accoding to the standard of fracture healing,excellent result was obtained in 35 cases and good in 21 cases,the excellent-good rate was 100%.Conclusions Abduction brace combined with manipulative reduction is an effective treatment for fracture of the surgical humerus neck in children.

Objective To explore the clinical effect of periodontic treatment in type 2 diabetic patients (T2DM ) with chronic periodontitis on basis of hypoglycemic therapy. Methods From September 2011 to January 2014 ,120 T2DM patients with chronic periodontitis were selected and divided into treatment group and control group with 60 cases in each group. Patients in control group were treated with conventional hypoglycemic therapy. Patients in treatment group were treated with initial periodontal therapy additionally on basis of conventional hypoglycemic therapy. Probing depth (PD) ,attachment loss (AL) ,plaque index (PLI) ,bleeding index (BI) and hypersensitive C reactive protein (hsC‐RP) levels were compared before and after 6 weeks treatment. Results PD ,AL ,PLI ,BI ,and hsC‐RP levels had no significant difference between two groups before treatment (P>0.05). PD ,AL ,PLI ,BI and hsC‐RP levels after treatment in treatment group were all significantly decreased [PD :(2.11 ± 0.28) vs (2.51 ± 0.68) and (2.42 ± 0.31) mm ;AL :(3.18 ± 0.41) vs (3.58 ± 0.83) and (3.49 ± 0.58) mm ;PLI:(0.41 ± 0.21) vs (0.96 ± 0.33) and (0.78 ± 0.26);BI:(0.97 ± 0.32) vs (2.65 ± 1.21) and (1.14 ± 0.30);hsC‐RP :(1.02 ± 0.63) vs (3.29 ± 2.88) and (2.72 ± 1.51) mg/L] as compared with those before treatment in treatment group and those after treatment in control group (P<0.05). Conclusion Levels of inflammatory factors will decrease when periodontic treatment is added to the antidiabetic therapy in T 2DM patients with chronic periodontitis.

Autoimmune hypophysitis is an inflammation of the pituitary gland resulting from autoimmune response, which can be classified as primary hypophysitis and secondary hypophysitis according to the etiology.The clinical presentation includes hypopituitarism and a pituitary mass.The diagnosis is based on clinical findings and radiology, while the pathology serves as the golden standard.The treatment is aimed at reducing the size of the pituitary mass, replacing the defective hormones and decreasing hyperprolactinemia.This review is about the epidemiology, pathogenesis, diagnosis, and treatment of lymphocytic hypophysitis, hypophysitis secondary to cytotoxic T-4 blockade, and IgG4-related hypophysitis.

The prevalence of maternal obesity has risen dramatically in recent years. Maternal obesity increases the risk of adverse pregnancy outcomes, and can lead to chronic inflammation, oxidative stress, the change of cell factor homeostasis. The metabolic status of maternal obesity in the pre-pregnancy and pregnancy can alter the level of DNA methylation in the placenta, change the fetal programming, influence the pregnancy outcomes, and increase the risk of obesity related metabolic syndrome and other chronic diseases of offspring. Actively preventing and intervening in the maternal obesity can reduce the adverse pregnancy outcomes and increase the survival quality of the offspring.

ObjectiveTo observe the efficacy of electroacupuncture with different wave patterns, sparse wave, intense wave, and sparse-intense wave, on the therapeutic efficacy in treating mild cognitive disorder after ischemic stroke.MethodSixty eligible patients were randomized into a sparse wave group, an intense wave group, and a sparse-intense wave group, 20 in each group. The three groups were given electroacupuncture at Baihui (GV20) and Shenting (GV24) in addition to the basic acupuncture treatment.The Mini-mental State Examination (MMSE) and Activities of Daily Living (ADL) were adopted for evaluation before and after the intervention by the same practitioner.ResultThe total effective rate was 55.0% in the sparse wave group, 65.0% in the intense wave group, and 90.0% in the sparse-intense wave group, and thedifferenceswere statistically significant among the three groups (P<0.05); afterintervention, the MMSE score increased significantly and ADL score decreased significantly in the three groups (P<0.01), and the inter-group differences were statistically significant after intervention(P<0.01).ConclusionElectroacupuncture with sparse wave, intense wave, or sparse-intense wave all can improve mild cognitive disorder, while the general therapeutic efficacy of sparse-intense wave is higher than sparse wave and intense wave.