Objective:To compare the therapeutic effect of drum room injection and intramuscular injection of rat nerve growth factor on occupational noise-induced deafness (ONID).Methods:Sixty-six patients with ONID treatment from January 2018 to December 2019 in the People′s Hospital of Liaoning Province were divided into control group and study group by random number table, with 33 patients in each group. On the basis of conventional treatment, all patients in the study group were injected with 20 μg rat nerve growth factor in the drum room, and each ear was injected once every other day. The control group was given intramuscular injection of rat nerve growth factor 20 μg per day, and the patients in two groups were treatment for 28 d. The hearing threshold of left and right whisper frequency of the two groups were compared. The improvement of tinnitus, dizziness, headache, insomnia, other symptoms and the scores of Hamilton Depression Scale (HAMD) was compared between the two groups.Results:Before treatment, the hearing thresholds of left whisper frequency and right whisper frequency in two groups had no significant differences ( P>0.05). After treatment, the hearing thresholds of left whisper frequency and right whisper frequency in the study group were significantly lower than those in the control group: (23.8 ± 4.2) dB/HL vs. (34.5 ± 3.9) dB/HL, (23.2 ± 4.4) dB/HL vs. (35.9 ± 5.1) dB/HL, and there were statistical differences ( P<0.05). After treatment, tinnitus and dizziness symptom improvement rate in the study group were higher than those in the control group: 93.3% (28/30) vs. 72.4% (21/29), 15/17 vs. 8/16, and there were statistically significant differences ( χ2 = 4.584 and 5.705, P<0.05). There was no statistically significant difference in the improvement rate of headache and insomnia symptoms between 2 groups ( P>0.05). The total effective rate in the treatment group was significantly higher than that in the control group: 90.9% (30/33) vs. 69.7% (23/33), and there was statistical difference ( χ2 = 4.694, P<0.05). After treatment, the scores of HAMD of 2 groups were significantly decreased, and the scores of HAMD in the study group was lower than that in control group: (8.46 ± 3.13) scores vs. (10.55 ± 3.83) scores, and there was statistical difference ( P<0.05). The incidence of total adverse reactions between 2 groups had no significant difference ( P>0.05). Conclusions:The injection of mouse nerve growth factor into drum room to treat ONID can effectively improve the hearing level of patients, alleviate tinnitus and dizziness symptoms and improve adverse mood without obvious adverse reactions.

OBJECTIVE:To provide suggestions for perfecting the laws and rules of drug circulation in China.METHODS:To collect,classify and analyze the current laws and rules for drug manufacturing enterprices,common merchandising concerns,drug wholesale enterprises,drugs retail enterprises and pharmaceutical retail chain enterprises in the field of drug circula?tion.RESULTS&CONCLUSION:We should perfect the current laws and rules,and form the system of law for circulation of drugs applicable for each trade in the field of drug circulation,on the other hand,we should add the rules for chain trans-management,chain affiliation,merger,association,cooperation,drug electronic commerce etc.

Objective To realize the automatic conversion of material management information to branch-level material cost accounting. Methods According to the structure of material management system and cost accounting system, memory procedure of HIS was set to undertake the mission of information conversion. Results Automatic conversion of material management information to branch-level material cost accounting saved a lot of manpower and raised the efficiency and accuracy of cost accounting. Conclusion This solution is worth popularizing not only in other cost accounting but in information system integration and data sharing.

Objective To construct a computerized medical case archive system, which can realize the electronic storage of medical case. Methods Virtual print was used in archive computerized medical cases and electronic signature was used to ensure the legality of the archives. Results The system realized the patient-centered medical information integration and raised the level of medical information storage and management significantly. Conclusion The favorable foundation was established fully in the medical cases archiving system, but the system can be improved in future.

The chemical constituents of the gorgonian Isis minorbrachlasta have been studied for the first time. Th?marine specimen was collected off the Nansha Islands in the South China Sea . On the basis of spectral correlation (1H NMR,13C NMR,IR)four known compounds:gorgosterol,22 - epi-hippuristanol, ceramide and batyl alcohol, were indentified.

Connection between the superior colliculus(SC)and the dorsal and ventral lateral geniculate nuclei (LGd and LGv) were studied in adult golden hamsters using anterograde and retrograde pathway tracing methods 1. In four hamsters, the cytoarchitecture of the SC, LGd and LGv was examined in brain sections stained with Nissl's or Loyez's method. 2. A single injection of a mixture of ~3H-leucine and ~3H-proline was made into various regions of the SC in each of 4 animals (1 day survival) for studying the pattern of terminal distribution of the projections from the SC to the ipsilateral LGd and LGv. In animals where the injection site was located in the superficial gray layers of the lateral portion of the SC, labelled terminals were found in the caudal lateral part of the LGd and LGv. In the case where the injection was restricted in more medial part of the SC, the terminal labelling was observed in the rostral lateral portion of the lateral geniculate nuclei. 3. One day after an injection of horseradish peroxidase (HRP) into the LGd (4 animals), LGv(2 animals), or LP(2 animals) labelled neurons were observed in the superficial gray layers of the ipsilateral superior colliculus. No HRP-labelled neuron was detected in deeper laminae in the colliculus. These results indicate that neurons in the superficial gray layers of the SC project to the ipsilateral LGd and LGv, and the projections are organized topogra- phically according to the retinotopic or visual field map

OBJECTIVE:To provide information for diversified operation of Chinese pharmaceutical retail chain enterprises.METHODS:By means of introducing the concept of commodity management,its effective application in Chinese pharmaceutical retail chain enterprises was analysed.RESULTS&CONCLUSION:Chinese pharmaceutical retail chain enterprises should apply commodity management theory to searching the mode of diversified operation,for improving net sales and market competition ability.

OBJECTIVE:To discuss about the management of Chinese pharmaceutical retail commerce METHODS:According to the analysis of the operation models and existing problems of Chinese pharmaceutical retail commerce,this paper brings forward concrete management strategy RESULTS & CONCLUSION:Chinese government and pharmaceutical retail enterprises should adopt effective management strategy to promote development of Chinese pharmaceutical retail commerce

OBJECTIVE:To provide the concept of management of circulation of commodities for Chinese pharmaceutical retail chain enterprises METHODS:According to the concept of management of circulation of commodities,to analyze its application in Chinese pharmaceutical retail chain enterprises RESULTS &CONCLUSION:Chinese pharmaceutical retail chain enterprises should search a mode of management of circulation of commodities which is appropriate for self-development to promote market competition ability

[Summary] Cardiovascular disease ,diabetic nephropathy and diabetic retinopathy are common complications of diabetes ,and are the significant reason of cardiovascular mortality ,end-stage renal disease ,and blindness in adults patients with type 2 diabetes mellitus. At present, the researche on the pathogenesis of diabetic complications mainly focus on oxidative stress and chronic inflammation. In addition, a large number of studies have pointed out that bilirubin has antioxidant and anti-inflammatory effects. Therefore, bilirubin and diabetic complications are closely linked.