Objective To study the protective effect of leuprorelin particle on ovarian reserve function applied before the laparoscopic cystectomy of ovarian endometriosis.Methods 106 patients with endometriosis treated from January 2015 to December 2015 in our hospital were selected.The subjects were divided into two groups according to the random number table, 53 cases of each group.The control group adopted the laparoscopic surgery;the observation group took the leuprorelin particle before the laparoscopic surgery.The operation condition, ovarian hormone and function were observed. Results The operation time and bleeding amount in observation group was better than control group ( P <0.05 ) .After surgery, the exhaust time between two groups had no significantly different.After surgery, the level of follicle stimulating hormone (FSH) in observation group was lower than control group; the level of estradiol (E2) in observation group was higher than control group (P <0.05); the level of luteinizing hormone (LH) between two groups had no significantly different.After surgery, the ovarian volume and antral follicle count ( AFC) in observation group was better than control group (P<0.05).Conclusion Before the laparoscopic cystectomy of ovarian endometriosis, the leuprorelin particle protects the ovarian function and morphology and has less impact in the level of hormone.

Heart Failure ; therapy ; Humans ; Practice Guidelines as Topic

Endothelial Cells ; metabolism ; physiology ; Stem Cells ; metabolism ; physiology

BACKGROUND:Wear particles factually serve as a medium carrying extensive information on the wear process involved in hip implants.Moreover,it has been demonstrated that wear particles contribute to the failure of Charnley total hip replacement.OBJECTIVE:To investigate the morphological characteristics of wear particles generated by couples of ultrahigh molecular weight polyethylene(UHMWPE) cups and Al2O3 femoral heads,mounted in a simulator in the presence of distilled water and explore the wear mechanism of UHMWPE cup.DESIGN:Wear tests were performed on a ball-in-socket hip simulator.SETTING:Department of Mechanical Engineering,Xuzhou Institute of Technology.MATERIALS:The molecular weight of UHMWPE selected as cup was 3 000 000.Its density was 0.935 g/cm3,hardness 30 HB,fracture strength 35 MPa,and water absorption 450 MPa,and tenacity 7 MPaM1/2.METHODS:The experiment was performed in the laboratory of tribology,China University of Mining and Technology from December 2003 to July 2005.Hip simulator was used to assess the tribological performance of Al2O3-UHMWPE at room temperature,100 r/min,784 N load for 1.5?106 cycles.Distilled water was used as the lubricant.Wear of UHMWPE acetabulum was measured every 3?105 cycles by taking out the acetabulum from simulator,cleaning in distilled water for 3 minutes in an ultrasonic bath,putting in an oven for 40 minutes at 80 ℃,and cooling off in a desiccator.A BT211D electronic balance(reciprocal sensibility,0.01 mg) was used to measure the weight loss of UHMWPE acetabula according to the reference sample method to calculate the wear.A sample(20 mL) of distilled water lubricant used in test was obtained when the simulator was stopped for gravimetric analysis.Morphology of wear particles in samples and surface of worn UHMWPE acetabula were observed by using scanning electron microscope(SEM).The components of wear particles were determined by X-ray.Detailed measurements of the wear particles distribution were conducted by LS100(R) Laser Particle Size Analyzer(including LS SVM Plus).MAIN OUTCOME MEASURES:Morphology and size distribution of wear particles;Wear mechanism and wear rate of UHMWPE acetabula.RESULTS:The wear particles showed a wide range of particle sizes,varying from 0.3 to 180 ?m,most of which ranged from 5 to 20 ?m.More than 99% of wear particles were UHMWPE particles,which were classified into five groups in terms of their morphological characteristics:spherical particle,tearing particle,lamellar particle,fatigued flaking and rod-shaped particle.Lamellar or cube was the predominant form of Al2O3 ceramic particles with flat surface structure and upright edges.The worn surfaces of UHMWPE cup showed evidence of multidirectional scratching,adhesive and micro-contact fatigue wear,and plastic deformation.CONCLUSION:①The dominant wear mechanisms acting in the UHMWPE cup are abrasive wear,adhesive wear,microcosmic fatigue wear and flaking associated with plastic deformation.②The size of particles accumulating mostly is tiny among the particle groups.

Objective To observe the effect of docetaxel combination with nedaplatin in the treatment of patients with advanced stage of normmall-cell lung cancer.Methods 72 patients with advanced stage of nonsmall-cell lung cancer were collected and randomly divided into observation group and control group.Docetaxel combination with nedaplatin was used in observation group and docetaxel combination with cisplatin was used in control group.The curative effect,no advancement time,total live time and adverse reaction were observed in each group.Results The CR rate 8.3％,PR rate 38.9％,total remission rate 47.2％ in observation group had no significant difference with control group.There was no significant difference in no advancement time and total live time between these two groups.The rate of digestive reactions was significantly lower in observation group than in control group ( all P ＜ 0.05 ).Conclusion Docetaxel combination with nedaplatin was an effective method in the treatment of advanced stage of nonsmall-cell lung cancer.The toxic reaction was low and easily to tolerte.

Alcoholic liver disease (ALD) is one of the most common chronic liver diseases in clinical practice with a complicated pathogenesis.Genetic factors play an important role in the pathogenesis of ALD and might be the potential targets for the treatment of ALD.This article reviews the susceptibility genes associated with ALD in recent years and points out that the exploration of the mechanisms of action of these genes in the development and progression of ALD can provide a theoretical basis for effective evaluation,diagnosis,and prevention and treatment of ALD in clinical practice.

OBJECTIVE: To probe into cognition of medical staff about TCM injection and iatrogenic factors of ADR caused by TCM injection in order to provide reference for rational use of TCM injection.METHODS: The cognition of 100 pharmacists and 100 nurses in 6 hospitals about TCM injection were surveyed using questionnaire.The results of survey were analyzed statistically.RESULTS: Most of the utilization of TCM injection was standardised.A small number of inappropriate utilization of TCM injection should be improved.CONCLUSION: Clinical pharmacists need to further improve their knowledge on TCM injection because of false cognition to avoid iatrogenic factors of ADR induced TCM injection and promote rational use of TCM injection.

DIA3 typing for human tissues was carried out by IEF- The results showed that the DIA3 typescould be demonstrated in testis, ovary, uterus and dental pulps ;but could not be demonstrated in thehuman brain, liver, kidney, adrenal gland, spleen, intestine, pancrease, heart, lung, skin, muscle, blood,vaginal secretion and hair root. The relative activty of DIA in different human tissues,blood and vagi-nal secretion DIA activity of different tissues and the DIA band intensity by PAGIEF were basecallyconsistent. The author were examined by spectrophotometric analysis. The relative suggests that theDIA3 typing of reproductive organs and teeth by PAGIEF plays a significant role for medicolegal individualization,The vaginal sectetion did not interfere with DIA3 typing of semen in mixed stain for theindividualization.

OBJECTIVE:To prepare nystatin buccal adhesive tablets and to study their properties of bioadhesion.METHODS:Nystatin buccal adhesive tablets of different formula matching ratio were prepared with carbomer(CP)and hy?droxy-propyl methyl cellulose(HPMC)as adhesive material and slow-release framework,and the adhesive power,duration of adhesion,swelling percentage and surface pH data of which were determined.RESULTS:There were great differences regarding bioadhesive properties among the adhesive tablets that of different formula matching ratio,the adhesive tablets that prepared in a formula matching ratio of1:1between CP to HPMC were of the best adhesiveness outcome.CONCLUSIONS:The buccal adhesive tablets were prepared successfully,and which can be used for the further study both in vivo and in vitro.

Objective To investigate the significance of bone mineral changes in the pathogenic process of glucocorticoid-induced avascular necrosis of femoral head(GANFH).Methods Thirty-two New Zealand rabbits were randomly divided into two groups(16 each).Animals in model group received an intramuscular injection of hydrocortisone acetate(8.0mg/kg) twice a week for 8 weeks totally,and animals in control group received an intramuscular injection with the same volume of normal saline,while 150kU penicillin were injected twice a week for preventing infection in both groups.The contents of serum calcium(Ca) and phosphorus(P) were determined,and the bone mineral densities of the femoral head and neck were measured at the 2nd,4th,6th,8th and 12th weeks after treatment.Meanwhile,the general condition such as weight,spirit and hair of rabbits was observed.Results Compared with the control group,the weight of rabbits in model group lost since the first week,and progressively aggravated;the bone mineral density of the femoral head and neck lowered since the 2nd and 4th week respectively(P