Objective To investigate the change ofpermeability surfaces (PS) of CTperfusion(CT-p) before chemotherapy and early period treatment with chemotherapy (the first cycle of chemotherapy) in advanced non-small cell lung cancer and explore the correlation with the efficacy of chemotherapy.Methods Eighty patients with advanced non-small cell lung cancer which confirmed by pathology were taken standardized treatment by first-line drug.All patients performed with the CT-p technique before chemotherapy and one cycle after chemotherapy.The efficacy was evaluated by RECIST after 4 cycles of chemotherapy,the patients were divided into complete remission (CR) + partial response (PR),stable (SD),development (PD) according to the results and the change of PS was compared among these groups before chemotherapy and after 1 cycle of chemotherapy.Results Seventy-four patients' values of PS were useful.The remission rate and the stability rate was 32.4％ (24/74) and 78.4％ (58/74) respectively after 4 cycles of chemotherapy.PS after 1 cycle of chemotherapy in CR +PR (24 cases) and SD (34 cases) was lower than that before chemotherapy (12.38 ± 1.86 vs.18.13 ± 2.45,13.24 ± 1.97 vs.17.93 ± 2.38),and there was significant difference (P ＜0.05).There was no obvious change in PS before chemotherapy and after 1 cycle of chemotherapy in PD (16 cases),and there was no significant difference(P＞ 0.05).Conclusions The value of PS which reflects the change of perfusion in tumor vessel at early chemotherapy and the prognosis of the non-small cell lung cancer.Use the change of PS to predict the prognosis of patients with chemotherapy.It could be the norm of calculating the curative effect of chemotherapy in non-small cell lung cancer.

Hepatocellular carcinoma (HCC) complicated by arterioportal shunt (APS) is commonly seen in clinical practice,with an incidence rate of 28.8％-63.2％.It is manifested as abdominal pain,diarrhea,and ascites and can also lead to serious complications of portal hypertension including gastrointestinal bleeding.Although there are various therapeutic methods,they tend to have poor clinical effects.APS is one of the most important causes of death in patients with HCC.This article introduces the etiology,typing,clinical manifestation,and therapies of HCC complicated by APS and points out that although there are various therapeutic methods for HCC complicated by APS,interventional treatment remains the most important method.The exploration of interventional treatment helps to improve patients' prognosis.

Objective:To study the scalp electroacupuncture combined with language training on the language function of post-stroke aphasia patients.Method:Ninety patients were divided into experimental group and control group by random number table method.The patients in the experimental group were treated by language rehabilitation training combined with electroacupuncture,while the control group was treated only by verbal training.Schuell stimulation was performed by one to one training and different types of aphasia patients focued on the different types of training.A course of treatment consisted of 2 weeks training with 30mins for each time,5 times a week.For acupuncture treatment,scalp acupuncture points were employed with motor area for motor aphasia,sensory area for sensory aphasia and three language areas for complete language aphasia,also combined with Baihui,wind House,dumb gate and other points.All patients received a course of treatment.The language function was evaluated by using Chinese Aphasia Test and the scores of spontaneous speech,language comprehension,repetition and nomenclature were compared before and after treatment.The degree of aphasia was assessed by the Boston Diagnostic Aphasia Examination (BDAE).The total efficacy was compared by Boston Diagnostic Aphasia.Result:There were significant differences in spontaneous speech,verbal comprehension,repetition,nomenclature and aphasia scores in the experimental group before and after treatment(P=0.01,0.03,0.02,0.02,0.02,P＜0.05)There were significant differences(P=0.02,0.03,0.01,0.02,0.03,P＜0.05) in the spontaneous speech,verbal comprehension,repetition and nomenclature and aphasia scores in the control group before and after treatment.There were significant differences in spontaneous speech,verbal comprehension,repetition,nomenclature and aphasia scores between the two groups(P=0.03,0.03,0.03,0.02,0.03,P＜0.05).There was significant difference in the total curative effect between the two groups(P=0.03,P＜0.05).Conclusion:The scalp electroacupuncture combined with language training can significantly improve spontaneous speech,verbal comprehension,repetition and naming degree score and aphasia for post-stroke patients,and has better curative effect than pure language training.

[Objective] To research the progress of traditional Chincse medicine in the treatment of cancer-relatcd sweating.[Methods]Search the relevant literatures on the treatment of cancer-related sweating in the last 20 years at home and abroad,from the etiology,pathogenesis,treatment methods,pharmacology,mechanism of action,clinical remission rate to review.[Result] Compared with modern medical treatment,traditional Chinese medicine treatment significantly improved the clinical remission rate and quality of life of patients with cancer-related sweating through the method of syndrome differentiation and the flexible administration way,the side effects were also very small.[Conclusion] Traditional Chinese medicine treatment plays an important role in the treatment of cancer-related sweating,which provides new ideas and methords for prevention and treatment.It is worthy of clinical application and popularization in the treatment field.

Objective To investigate the value of multi-slice spiral CT(MSCT)in diagnosis of the causes of intestinal obstruction.Methods 49 cases of intestinal obstruction confirmed by surgery or clinical diagnosis underwent abdominal MSCT plain and enhanced scanning,three-dimensional post-processing reconstruction was done in 5 cases.CT features were analysed blindly by two senior radiologists,including the thickness,density and degree of enhancement of intestinal walls at the "transition zone" area of intestine and surrounding mesenteric structure.The causes of intestinal obstruction were analysed in combination with clinical history of the patients.Results The causes of intestinal obstruction were suggested by MSCT in 46 cases(94%),including intestinal adhesion in 13 cases,tumor in 11,hernia in 4,ischemic bowel disease in 4,gallstone in 2,gastrolith in 2,Bezoar in 4.paralytic ileus in 3 and appendiceal abscess in 3.Three cases were misdiagnosed.Conclusion MSCT is of significant clinical value in diagnosis of intestinal obstruction,which should be used as the first means in clinic practice.

Objective To explore the value of electrophysiology in diagnosis of myotonic dystrophy .Methods Electromyogra-phy(EMG) and nerve conduction were detected in 26 myotonic dystrophy patients(myotonia group) .Myotonic discharges were de-tected in 25 patients with non-tonic neuromuscular disease(control group) .Results The main features of EMG in myotonia group were myotonic discharges ,myogenic damage ,and normal nerve conduction .There was no myotonic discharges in control group .The positive rate of myotonic discharges of abductor pollicis brevis was 87 .5% .The positive rate of myotonic discharges of extensor digitorum communis was 77 .8% .The positive rates of myotonic discharges of anterior tibial muscle ,quadriceps femoris and trian-gular muscle are 57 .1% ,45 .5% and 45 .5% respectively .Conclusion Myotonic dystrophy distinguished from other neuromuscular disease might be mainly based on myotonic discharges and myogenic damage .Myotonic discharges were mainly observed in the small hand muscles .However ,the positive rate of abductor pollicis brevis ,which has the highest chance of myotonic discharge ,was less than 100% .

The occurrence of 20 to 25 percent of ovarian cancer is associated with genetic factors.Hereditary ovarian cancer includes genetic ovarian cancer and familial ovarian cancer.The genetic characteristics of tumors and the development of gene testing technology make it possible to detect tumor-related mutational genes by testing the gene of the proband and thus identify the other family members at risk and intervene early so as to realize early prevention and detection of the cancer.The paper reviews the genetic basis and pathogenesis of hereditary ovarian cancer as well as methods of detecting mutational genes, management of the proband, problems at present, and disease prevention for high-risk individuals.It stresses that we should pay attention to hereditary ovarian cancer in clinical work, identify the proband, and make comprehensive evaluation of risks of the patients` relatives so as to provide individualized guidance and carry out the concept of precision medicine.

Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P