The morphological changes of the humerus and femur were examined in 52 sports- men (30 weight-lifters-static type of movement and 22 runners—dynamic type of move- ment).The results were as follows: 1.In the humerus of the weight-lifters the thickness of the wall of bone was very much increased as compared with that of the runners and,as a result,the transverse diameter of the shaft enlarged and the cavity diminished. 2.In the femur,however,no such changes were observed in both types of exercise. On the contrary,there is some indication that the femur of the runners increased in longitudinal direction. 3.In the weight-lifters,the thickness of the wall of the bone was not only shown in the shaft,but also in the metaphyses where it ended as a sickle in the longitudinal section.On the other hand,that of the runners gradually pointed out. 4.The bony prominences of the humerus of the weight-lifters were very much marked and its internal bony lamellae were clearly visible.

For a period of 3 months,an experimental exercise under the influence of dynamic and static factors was given to 3 groups (15 each) of mice.The histological changes of the extensor muscle of the post extremities of these mice were examined by the Bielschowsky-Gros and H.E.methods.The result,as compared with that of the control group,was summarized as follows: 1.The structural changes of the muscle fibers differ in different groups under the influence of different mechanical factors,for instance,under the influence of static factors either the muscle fibers as a whole or their nuclei were enlarged mainly along the trans- verse diameter. 2.The increase in number of nuclei of the muscle was observed in the experi- mental animals among which the dynamic type was most conspicuous.This increase was not only related to the character of mechanical factors,but also the intensity of the muscular activity. 3.Under mechanical factors,the nuclei of the muscles were increased both in number and in size.Under the influence of dynamic factors,the nuclei increased pre- dominantly in length (long type nuclei) while under the influence of static factor,its in- crease was mainly along the transverse direction.In the latter the transverse diameter of the long type nuclei was also wider and tends to become oval in shape.It is,therefore, assumed that the type and number of the nuclei of the muscle cells depend upon the func- tional activity of the organ and the character of the force acting upon it. 4.After a long period of exercise,either by means of dynamic or static factor, a large number of annular nuclei was found in the muscles.This phenomenum has not been reported in the literature.

Fifteen mice, were divided into 3 groups, each was trained to adopt a particularfunctional state of muscular activity for a long term. The histological changes of theirmotor end-plates were examined by means of the Bielschowsky-Gros and the Ranvier'sgold chloride techniques. The results were summarized as follows: 1. It was found that, by increasing the dynamic or static functional activity of mus-cles of the mice, the motor end-plates were enlarged in size and their nuclei were in-creased in number, as compared with those of the control group. 2. The size of the nuclei of the end-plates of both experimental groups was notequally affected, e.g., the nuclei in the static group were larger, while those in the dyna-mic group were comparatively smaller. 3. Under the influence of the dynamic or static muscular exercise, the end-platesincreased in their sizes, more so in the static than in the dynamic group, while the controlgroup remained to be the smallest. The diameter had a tendency to increase along thelong axis in the dynamic group, and along the transverse axis in the static group; hencethe end plate appeared to be oblong in the former and oval in the latter group. 4. After a long term of muscular exercise, whether dynamic or static in nature, thenerve fibers supplying the end-plates increased in thickness and degree of complexity oframification. There were some unidentified cells with annular nucleus in the vicinity ofthe end-plate. 5. Mechanism of the changes of the motor end-plates was discussed in the light offunctional morphology.

Objective To investigate the clinical significance of serum D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods 98 patients with COPD were selected as the research objects,including 38 patients with stable COPD and 60 patients with AECOPD.At the same time,fifty healthy subjects were enrolled in this study as healthy control group.The arterial blood gas(pH,PaCO2,PaO2,PaO2/FiO2),pulmonary function(FVC％,FEV1％,FEV1/FVC) were detected,plasma D-D were measured by immunoturbidimetry with fully automated biochemical analyzer.Results The PaCO2 of the stable COPD group and the AECOPD group were (45.30 ± 3.18) mmHg and (51.44 ± 5.12) mmHg,which were significantly higher than that of the healthy control group[(39.45 ± 4.05) mmHg] (t =4.414,7.556,all P ＜ 0.01).Tthe PaO2,PaO2/FiO2,FVC％ and FEV1/FVC were significantly lower than those of the healthy control group (t =3.618,7.702,21.433,26.316,4.323,8.302,5.112,10.384,4.191,9.511,all P ＜ 0.01).The PaCO2 of AECOPD group was significantly higher than that of the stable COPD group(t =4.331,P ＜ 0.05),while the PaO2,PaO2/FiO2,FVC％,FEV1 ％ and FEV1/FVC were significantl) lower than those of the stable COPD group(t =5.702,4.652,3.773,6.241,5.806,all P ＜ 0.05).The serum DD of the healthy control group was (0.33 ± 0.05) mg/L,which of the stable COPD group was (0.77 ± 0.08) mg/L,which of the AECOPD group was (1.58 ±0.10)mg/L,and the difference of the these groups was statistically significant(F =14.667,P ＜ 0.01).The plasma D-D of the stable COPD group and the AECOPD group were significantly higher than that of the healthy control group (t =4.667,13.224,all P ＜ 0.05).The plasma DD of the AECOPD group was significantly higher than that of the stable COPD group (t =9.471,P ＜ 0.05).There were positively correlation betweem D-D and PaCO2 (r =0.661,P ＜ 0.05),and there were negatively correlation betweem D-D and PaO2/FiO2 and FEV1/FVC(r =-0.964,-0.589,all P＜0.05).Conclusion D-dimer is correlated with arterial blood gas and lung function.D-dimer test can help to evaluate the stage and severity of COPD accurately,which is helpful for effective treatment.

Objective: To observe the curative effects of high tibial osteotomy with slotting plate for the treatment of osteoarthritis of the knee with genu varum.Methods:The general status of all patients were comprehensively evaluated.Their weight bearing lines of lower limbs were measured at standing positions in order to determine the angles of corrective osteotomy with high tibial osteotomy.Results:Evaluation was done according to the criterions made by Dou Baoxin 85.8% of curative effects were excellent and good,The ideal tibiofemoral angles were 170°～172° degree.Conclusion:With slotting plate fixation to correct the weight bearing line of lower limbs,with advantages of reasonable operative method,easy mastering of the angles of correction,and firm fixation and high union rate,is the best method to treat the osteoarthritis of the knee with genu varum.

Effect of lithium salt(Li)administnation to caudate-putamen nucleus (CPN) on pain response in the rat was studied by chronic cannula implantation and direct injection of drugs into the brain structurementioned above. The results were as follows:( 1 ) The injection of Li into anterior part of the head of CPN of rats produced significantly the analgesic effect that could be antagonized by naloxone, atropine,phento-lamine.propranolol, lysergic acid diethylamide and bicuculline, but not by haloperidol.(2) The injection of Li into central part of the head of CPN of rats did not produce analgesic effect.The results above showed that microinjection of Li into different parts of the head of CPN could give rise to different effects on pain response and the analgesic effect of Li could be related to metabolic changes of endogenous opioid peptides, acetylcholine, noradrenaline, gama aminobutyric acid and 5-hydroXytryptamin aad mediated by their receptors respectively

OBJECTIVE To improve the competition ability of the hospital,emphasis of the importance of hospital infection management is necessary and urgent.METHODS Our experience on improving culture level in hospital infection management was introduced.RESULTS We improved management efficiency by fluent information,altered the concept of value by bettered the management means,and brought the renovation idea by lifting the qualification of management staff.CONCLUSIONS Correctly making the most use of the unique principles of culture in hospital infection management could be benefit for creating a good atmosphere,establishing nice profession image,and setting up norm criterion,which could facilitate the controlling hospital infection.

Objective To investigate the role of chemokine in inducing peripheral arthritis in spondyloarthropathy(SpA).Methods Microarray was used to screen the candidates of inducing peripheral arthritis in SpA,and enzyme linked immunosorbent assay(ELISA)was used to verify the results.Peripheral blood mononuclear cells(PBMC)from 5 healthy subjects were co-incubated 1.5 hours with synovial fluid of 5 patients with SpA,total RNA were then extracted,and the samples were screened for the target genes by using superarray techniques.ELISA was used to determine CXCL1 protein levels of 54 ankylosing spondylitis(AS)patients and 30 healthy controls,also to determine the CXCL1 levels of synovial fluids from 33 SpA patients and 14 osteoarthritis(OA)patients,and to determine CXCL1 protein levels by ELISA before and after treatment with infliximab.Results The expression of CXCL1,CXCL2,CXCL3 and IL-8 were more than 2 fold higher after stimulated by synovial fluids.However,there was no change in other chemokines and cytokines,such as TNF?,IL-6 and IL-1 after stimulation.The protein level of CXCL1 was significant higher in serum of patients with AS than that of healthy control(P

The experimental regeneration of patella was studied in 15 young mice. After ex-cision of the patella these animals were raised under different living conditions. Ingroup A, the animals were kept under daily training for an hour by running on a turningwheel in order to intensify the movement at the knee joint. In group B, the animalswere kept in a cage large enough for free movement. In group C, the animals were con-fined in an apartment in the cage where their movement was limited to minimum. Afterthree months, the regeneration of the patella in these animals was examined by means ofroentgenographic and histologic methods. The results were as follows: After the patella was excised in young mice, a new one was formed if free movementat the knee joint was allowed. If, on the other hand, the movement was limited arti-ficially, no regeneration of the patella occurred after three months. But if the movementwas intensified by training, the formation of a new patella was accelaerated. Therefore,it may be held that the formation of the new patella is dependent upon the conditionof the functional activity of the knee joint. In addition to the new petella, some ac-cessory ones were also formed in the running group. The above results indicated that such mechanical factors as compression force, tensileforce and frictions at the tendon of the quadriceps muscle are indispensible conditions forthe regeneration of the new patella. The histological evidence also shows that the formation of the new bone was broughtabout through the fibrochondral ossification, and no intramembraneous ossification wasobserved. The structure of the new patella was characterized by all the morphologicalfeatures commonly seen in the cancellous bone. The time required for the regenerationof the new patella in mice ranged from 1.5 to 2 months. The mechanisms in, and condi-tions for the formation of new patella were dicussed from the aspect of functional mor-phology.

VTK is not only an open-source code but also a powerful toolkit for visualization.According to the requirement of medical image processing and on the basis of visualization and display function of VTK,VC++6.0 is used to design and implement a three-dimensional system which can be integrated into PACS.This system is useful for advancing the post-processing function of PACS.