Objective To investigate the effect of calcipotriol on psoriasis and its effect of peripheral blood interleukin-2(IL-2), interferon-γ(IFN-γ), IL-4 and IL-10 and the percent of cell TH17.Methods From March 2013 to June 2016, 96 patients with psoriasis vulgaris inour hospital were randomly divided into control group and study group according to different treatment regimens, each group 48 cases.The control group was treated with YujinXiaoyin Decoction, and the study group was treated with YujinXiaoyin Decoction and calcipotriolointment,both groups were treated for 3 months.Treatment effect, psoriasis lesion area and severity index(PASI) score, the incidence of adverse reactions were statistically analyzed of the two groups,and the levels of IL-10, IL-2, IFN-γ, IL-4 and peripheral blood TH17 cells percentagewere measured and compared.Results The treatment effectafter treatmentfor 1month, 2 months and 3 months of the study group were significantly higher than those of the control group, but PASI score was lower than the control group, the difference was statistically significant(P<0.05);The peripheral blood IL-10, IL-2, IFN-γ and IL-4 levels after treatment for 3 months in the study group were significantly lower than those before treatment, and was significantly lower than that of the control group(P<0.05);The percentage of TH17 cells in the two groups after treatment for 3 months was significantly lower than before treatment, and the study group was significantly lower than that of the control group(P<0.05);The incidence of adverse events in the study group(4.17%) was lower than that in the control group(18.75%) after treatment, the difference was statistically significant(P<0.05).Conclusion The efficacy of carbapenol in the treatment of psoriasis is significant, which can effectively improve the skin lesions and reduce the the peripheral blood IL-10, IL-2, IFN-γ, IL-4levels and the safety is high.

Objective: To analyze the genetic polymorphism and relationship of Sophora alopecuroides from Ningxia, Gansu, Qinghai, Xinjiang, and Inner Mongolian in China, and to offer some information for the domestication and protection of wild S. alopecuroides germplasms. Methods: ISSR primers were used to analyze the genetic diversity of 22 populations of S. alopecuroides. Cluster analysis of the unweighted pair-group method with arithmetic average (UPGMA) and principal component analysis (PCA) were carried out based on the molecular data obtained, and a dendrogram was constructed. Results: Totally 433 alleles were amplified using the 51 ISSR primers. The number of allels in per primer range was 5-12, with an average of 8.49. The average percentage of polymorphic loci (PPB) was 93.30%. The Nei's gene diversity (H) and Shannon's information index (I) were 0.3351 and 0.4998, respectively. The genetic distances range was 0.1736-0.6502. Conclusion: The genetic polymorphism among 22 populations of S. alopecuroide is relatively abundant and there are no direct relationship between genetic distance and geographical distribution in them.

Objective:The current evidence suggests that tumor necrosis factor-inhibitor (TNFi) treatment can be used to achieve clinical remission or low disease activity in patients with ankylosing spondylitis (AS). After achieving remission / low disease activity, however, the follow-up treatment options are unclear. The purpose of this review is to conduct an extensive and systematic literature review of the studies conducted from September 2014 to July 2020 to assess the feasibility and effectiveness of tapering of biological agents.Methods:After searching for the related papers and abstracts and applying inclusion/exclusion criteria, a structured extraction process was used to include the studies into this study.Results:A total of 13/93 studies were included into the analysis of the tapering of biological agents in AS patients, in which 7/13 adopted the dose reduction regimen, 3/13 adopted the extended interval between doses regimen, and 5/13 did not provide or formulate the detailed reduction regimen. We summarized the feasibility of TNFi tapering schemes in the published studies and summarized the tapering rules. Only one study showed that reduced TNFi levels worsened the quality of life and resulted in a relapse within 12 months.Conclusion:More research is needed to understand the long-term effects of these strategies on efficacy, safety, and cost in the treatment of AS.

Although locoregional recurrence (LRR) after mastectomy is regarded as a signal of disease progression,but it is different from distant metastasis.Some patients could have better prognosis and benefit from salvage treatments,especially for patients with isolated LRR.Time to recurrence,site of recurrence and number of recurrent nodules have great influence on the prognosis of patients with LRR.For suited patients with LRR,surgical resection and endocrine therapy are valuable in suitable cases,but the role of chemotherapy still need further study.

This paper presents a development model of resource information institute from organic integration the institute of information and library.The all data of resources-information institute come from and serve for theoretical research,clinical practice,and scientific research of TCM.Comparing with usual research institute and library,the resource information institute has five dominant positions,which are subjects,scientific researches,resource,professionals and services.

Informatics of traditional Chinese medicine is an emerging subject.This dissertation analyzes the connotation and scope of the study of traditional Chinese medicine informatics.Through investigating the demand for personnel talents of Chinese medicine hospital and Information Institute of TCM,we comment on with what theoretical basis and practical abilities the TCM information personnel talents should possess.It also proposes the training mode and optimization measures of TCM Informatics education.

Objective To study the changes of the symptoms and quality of life in the patients after the transvaginal tape-obtura-tor(TVT-O) operation .Methods To retrospectively analyze the clinical data of 96 female patients with stress urinary incontinence (SUI) in our hospital from February 2007 to April 2012 .48 cases of retropubic tension free vaginal tape(TVT) were taken as the control group and 48 cases of TVT-O as the experimental group .The intraoperative general condition and postoperative symptoms changes and life quality were analyzed and compared between the two groups .Results The operation time ,blood loss and hospital stay time in the experimental group were significantly less than those in the control group (t=17 .061 ,17 .026 ,15 .465 ,P>0 .05) , the difference of operative effects between the two groups was not statistically significant (χ2 =0 .711 ,P>0 .05) .After treatment , all the patients′scores of quality of life were significantly improved compared with that before treatment (29 .1 ± 9 .6 ,30 .3 ± 9 .8 vs . 70 .4 ± 10 .2 ,68 .5 ± 11 .4 ,P<0 .05) ,but score differences between the two groups showed no statistical significance (P>0 .05) ,af-ter treatment ,the symptom scores and urinal pad use of two groups were obviously improved compared with those before treatment (13 .9 ± 2 .8 ,14 .1 ± 2 .5 vs .5 .1 ± 1 .2 ,5 .4 ± 1 .7 89 .6% ,93 .8% vs .50 .0% ,58 .3% ,P<0 .05) ,but the differences between the two groups were not statistically significant (P>0 .05) .Conclusion TVT-O can improve the symptoms and quality of life in the pa-tients with SUI .In the same time ,it has advantages of minimal invasion and low risk ,which is worth promoting ,but the surgeons need to accumulate more clinical experience .

Objective To investigate the effect of hyperuricemia on early renal damage in patients with type 2 diabetic,and to explore the improvement of albumin-to-creatinine ratio (ACR) after lifestyle intervention to control the level of serum uric acid.Methods One hundred and sixty patients with type 2 diabetic mellitus from our hospital from January 2012 to December 2012 were recruited and divided into the high uric acid group (HUA,60 cases),and the normal uric acid group (NUA,100 cases).Fasting blood glucose (FBG),insulin (FINS),glycosylated hemoglobin (HbA1c),serum lipid levels,morning urine albumin-to-creatinine ratio (ACR) were detected in each group,and body mass index (BMI),insulin resistance index (HOMA-IR) were calculated.The HUA group was intervened by lifestyle for at least 6 months,and related indexes were measured again.Results The FINS,HOMA-IR,ACR and triglyceride(TG) of the patients in the HUA group were higher than that in the NUA group((110.33 ±38.73) pmol/L vs.(72.64 ±21.94) pmol/L,t =2.876; (7.0 ±2.3)vs.(4.6±1.3),t =2.364;13.6(5.1,53.2) mg/mmol vs.6.4(2.9,16.8) mg/mmol,H=3.390;(2.53± 1.45) mmol/L vs.(1.71 ± 1.32) mmol/L,t =2.626 ; P ＜ 0.05).By the Spearman correlation analysis,the level of serum uric acid was positively correlated with FINS,HOMA-IR,ACR,and BMI (r =0.304,0.225,0.248,0.271 respectively; P ＜ 0.05).After adjusting the factor of age,duration,obesity,blood glucose and insulin resistance,the level of serum uric acid was still positively correlated with ACR (r =0.312,P ＜ 0.01).The FINS,UA,HOMA-IR and ACR in group HUA were lower than those before lifestyle intervention ((463.7± 18.6) μmol/L vs.(380.3 ± 9.5) μmol/L,t =3.065 ; (110.33 ± 38.73) pmol/L vs.(83.30 ± 28.21)pmol/L,t =2.532; (7.0 ±2.3) vs.(5.0 ±0.9),t =2.165;13.6(5.1,53.2) mg/mmol vs.8.1(4.9,20.4)mg/mmol,H =2.912 ; P ＜ 0.05).Conclusion The patients with type 2 diabetes complicating hyperuricemia were likely to having abnormal ACR.Controlling the level of serum uric acid by lifestyle intervention may be benefit for delaying the development of early diabetic nephropathy in patients with type 2 diabetes.

OBJECTIVE:To discuss the related measures for the reduction of medical expenses.METHODS:The related data concerning hospital drug revenues before and after the operation of’pharmaceuticals purchase by public bidding’were compared,and reasons for the high undescended hospital drug expenses were analyzed.RESULTS:Although the drug revenues kept increasing year by year,yet the profits gained by hospitals from which decreased year by year,which may resulted from many factors.CONCLUSIONS:The operation of the’pharmaceuticals purchase by public bidding’failed to bring down the high medical expenses.

In recent years the incidence of acute kidney injury (AKI) has increased, with a high mortality rate and poor prognosis.The key of improving the prognosis of AKI is early diagnosis and intervention.Due to the lack of biomarkers of early diagnosis in AKI, the effective early treatment is generally delayed.Traditional diagnosis biomarkers such as serum creatinine and blood urea are delayed and affected by various factors.Recently, some new potential early diagnostic biomarkers have been found.MicroRNA(hereinafter referred to as the miRNA) is a kind of endogenous non-coding small RNA, and studies have shown that it is related to the development of AKI.