Objective To explore the application effect of single port laparoscopic techniques in urology grassroots.Methods 60 patients with upper ureteral stones were randomly divided into observation group(using single port laparoscopic technique lithotripsy) and control group (30 cases with open surgery).The surgery time,blood loss,hospital stay,postoperative complications were compared between the two groups and the patients were followed up for three months,the clearance rate of stones and patients' satisfaction were observed.Results The operative time between the two groups had no significant difference(t=1.559,P>0.05).The blood loss of the observation group was significantly less than that of the control group[(128.3±10.32)mL vs.(76.4±9.65)mL],the difference was statistically significant(t=20.003,P<0.01),and the hospitalization time was shorter than that of the control group[(5.86±1.47)d vs.(7.95±1.53)d],the difference was statistically significant(t=5.395,P<0.01).The incidence rate of postoperative complications of the observation group was lower than that of the control group(6.7% vs.30.0%),the difference was statistically significant(x2=5.454,P<0.05).Followed up for 3 months,the ESWL rate(73.3% vs.96.7%) and satisfaction rate (100.0% vs.80.0%) in the observation group and the control group had statistically significant differences (x2=4.705,4.629,all P<0.05).Conclusion The single port laparoscopic technique lithotripsy in the treatment of upper ureteral stones has precise effect,less invasion,high ESWL rate,low complication rate and other advantages,and it is worthy of wide promotion.

Humans ; Maintenance Chemotherapy ; Multiple Myeloma ; therapy

BACKGROUND:Overtraining is a series of functional disorder or pathological state induced by continuous fatigue accumulation because exercise load and body function are incommensurate to each other. At present, commonly used methods for establishing rat models of overtraining included treadmil , swimming and climbing rod, but treadmil is comparatively accepted in the world.
OBJECTIVE:To establish the standard of overtraining rat model and to implement objective of model establishment by dynamical y monitoring biochemical indexes and observing behavioral changes.
METHODS:A total of 16 Sprague-Dawley rats were randomly assigned to model and blank control groups. The model group received movement training according to the plan. After adaptable feeding, training was performed, 6 days every week, with a rest of 1 day. Increasing intensity on treadmil was used. From the first week of training, the speed, gradient and running time were gradual y increased. However, the blank control group was conventional y fed, without any training.
RESULTS AND CONCLUSION:Behavior changes of the training rats were arisen after five weeks. Serum creatine kinase levels increased continuously in training process, and higher than basic levels at 5 weeks (P<0.01). Serum urea nitrogen levels persistently increased, and higher than basic levels at 3 weeks (P<0.05). Hemoglobin and serum testosterone levels increased and then decreased, and significantly lower than basic levels at 8 weeks (P<0.05). Behavioral y, overtraining appeared. Simultaneously, hemoglobin and serum testosterone levels were significantly lower than basic levels. Serum creatine kinase and serum urea nitrogen levels were significantly higher than basic levels. These results indicated that the body was in overtraining state. The standard of overtraining rat model was established in this study. The overtraining rat model was established according to the training program when the training was lasted for 8 weeks, the training speed was 30 m/min;every training time was 110 minutes, and the gradient was 15°.

Objective: To evaluate the preventive effect of ephedrine on hypotension under spinal anesthesia in patients with different age. Methods: Sixty patients scheduled for spinal anesthesia were randomly allocated to four groups with 15 each. Group Ⅰ and Ⅱ were adult patients aged from 25 to 55 years old and group Ⅲ and Ⅳ were geratic aged patients of 6575 years old. Every patient received a fluid loading of 7ml/kg before spinal anesthesia. The ephedrine was administrated to group Ⅱ and IV patients in a dose of 10mg i v and 30 mg i m and same amount of normal saline was administrated to group Ⅰ and Ⅲ as soon as spinal anesthesia was performed. Results:Thirty patients in the placebo groups developed a maximal decrease in MAP exceeding 20%. Ten of these (2 in group Ⅰ and 8 in group Ⅲ ) developed a decrease in MAP exceeding 35% and required treatment. In aged groups, all patients in group Ⅲ had a decrease in MAP exceeding 20 %, 53 % of whom, the decrease exceeded 35 %. Conclusion:Prophylactic use of ephedrine is effective in the prevention of hypotension during spinal anesthesia, especially in aged patients.

Objective To evaluate the effect of a biodegradable paclitaxel-eluting biliary stent on bile duct scar formation and biliary stricture by observing the healing process after stent placement in a porcine billiary model.Methods A novel biodegradable paclitaxel-eluting biliary polylactide stent was manufactured by immersion method.The efficacy of drug release for paclitaxel-eluting biliary stent was investigated by HPLC.Paclitaxel-eluting stent were surgically inserted in the bile duct of fifteen swines in experimental group while stent without paclitaxel were placed in other fifteen swines in control group.Animals were sacrificed after 1,3,6 months.The anastomic healing of the common bile duct was observed.The size of anastomosis was measured and compared between the two groups.Result A novel biodegradable paclitaxel-eluting biliary stent was manufactured.The total amount of paclitaxel released was about 281 pg (30.4％) over a month as determined with HPLC methods.There was no death,no leakage.The diameter of anastomosis in the experimental group was significantly larger than that in control group.Cholangiography did not show obvious bile duct dilatation in experimental group.Histologic examination showed less hyperplasia of the bile duct wall in the experimental group than that in control group.Conclusion Release of paclitaxel via a biodegradable stent relieves billiary stricture in porcine model and have no obvious negative influence on wound healing of the common bile duct.

Objective To find out the iodine nutritional status of school-age children in Yichang city,and to provide a scientific basis for prevention and control of iodine deficiency disorders.Methods In 2009,children aged 8 to 10 in each county(city,region) in Yichang city Hubei province were selected as study subjects.In each county (town,district),a township(town,street) was selected according to their orientation of east,west,south,north and center in the county.A village primary school was selected from each township(town,street).Twenty children aged 8 to 10 from each school were selected.Real-lime urine samples were collected to test iodine level.Results A total of 1300 urine samples of school children were collected and tested.The median urinary iodine was 277.4 μg/L.Therein,there were 11 children whose urinary iodine level was less than 20 μg/L,accounting for 0.8％ ; there were 28 children whose urinary iodine level was between 20 μg/L to 50 μg/L,accounting for 2.2％ ;there were 84 children whose urinary iodine level was between 50 μg/L to 100 μg/L,accounting for 6.5％; there were 606 children whose urinary iodine level was between 100 μg/L to 300 μg/L,accounting for 46.6％; there were 571 children whose urinary iodine level was more than 300 μg/L,accounting for 43.9％.There were 648 males,their median urinary iodine was 263.1 μg/L.There were 652 females,their nedian urinary iodinc was 277.5 μg/L.A total of 388 eight-year-old children's median urinary iodine was 277.5 μg/L.A total of 458 nine-year-old children whose median urinary iodine was 259.4 μg/L.A total of 454 ten-year-old children whose median urinary iodine was 295.8 μg/L.Conclusions The iodine nutrition of school-age children in Yichang city is in good condition,and complies with the national standard of eliminating iodine deficiency disorders.But the urine iodine content is higher than the appropriate level,so there is a need to strengthen the prevention work.

To assess the effect and the safety of Naoxinqing Tablet in treating cerebral atherosclerosis and angina pectoris of coronary heart disease. Forty-eight patients with cerebral atherosclerosis and 12 patients with angina pectoris of coronary heart disease served as the objects. The effective rates were 83.33% and 75.00% in cerebral atherosclerosis group and angina pectoris of coronary heart disease group respectively, and the total effective rate of Naoxinqing Tablet was 81.67%, the difference being significant as compared with those before treatment (P

The development of the nerves of the small intestine was studied in 26 human fetuses with the gestational age of 11 to 40 weeks.The findings are as follows:(1)The distance between the Auerbach's ganglia and the muscular layer is small in the early fetal period and it increases progressively as the fetus grows.(2)The density of neuropils increases gradually.(3)The number of large gradual vacuoles (LGV) is small in the 3rd month of gestation,and it increases gradually and is quite numerous in the 6th month.(4)The morphology of the synapses is not so typical as that of an adult.(5)The peak values of the stereological morphological parameters of the organelles in the neurons appear between the 4th-6th month and maintain at a relatively high level until the baby is bron.

The foot overpronation is termed as pronation persisting more than 25%of stance phase in a walking cycle, which may re-sult from some antenatal or postnatal conditions. Overpronation would lead to abnormal alignment of ankle, knee, pelvis and spine, and re-sult in a set of syndromes of chronic pain. The Navicular Drop Test and the Foot Posture Index are often used as the assessment tools, how-ever, there are several empirical ways for clinic. Foot orthoses, special shoes, taping and training of muscle strength are effective on overpro-nation as well as chronic pain.

Objective To compare the effects of and Smeton on inflammatory mediator levels and therapeutic outcomes in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Ninety AECOPD patients hospitalized at our department from June 2012 to June 2013 were selected and randomly divided into the group and the Smeton group.In addition to routine therapy,such as anti-infection medication and water & electrolyte balance maintenance,for both groups,patients in the group were given a single 10 mg oral dose of,taken at night before bedtime,while patients in the Smeton group were given 2 pills of a compounding formulation containing,three times a day,for two months.Changes in plasma inflammatory mediator levels before and after treatment and therapeutic outcomes were monitored.Results Highsensitivity C-reactive protein (hs-CRP) levels decreased and interleukin-10 (IL-10) levels increased two months after treatment,compared with pretreatment levels [hs-CRP,(4.01±0.69) mg/L vs.(15.23±4.39) mg/L,and IL-10,(19.44±6.35) g/L vs.(7.86±3.24) g/L,for the group; hsCRP,(7.09±1.70) mg/L vs.(7.86±3.24) g/L,andIL-10,(11.6±3.2 g/L vs.6.7±2.8 g/L),for the Smeton group; P＜0.05 or 0.01].The magnitude of increases or decreases in inflammatory mediator levels was greater in the group than in the Smeton group (P＜0.05 for both),and the overall effectiveness rate was higher in the Smeton group than in the group (95.6％ vs.82.2％,x2 =4.05,P ＜0.05).Conclusions When used for treatment of patients with AECOPD,ontelukast has more beneficial effects on inflammatory mediator levels,whereas is more effective in clinical symptom improvement.