Surgical resection is the only potentially curative therapeutic method for patients with gastric cancer. However, con-ventional laparotomy is sometimes associated with considerable complications and mortality rate. This procedure also affects patient quality of life after surgery. Minimally invasive techniques can potentially provide an attractive alternative to current surgical proce-dures in terms of reducing surgical injury and accelerating postoperative recovery. Minimally invasive surgery for gastric cancer has re-cently been reasonably applied to two distinct forms of intervention:endoscopic resection of the tumor and laparoscopic surgery. In the near future, sentinel node navigation and robot surgery will provide more options for treating gastric cancer. Such developments will im-prove the quality of life of patients following surgery for gastric cancer. Various well-designed clinical trials of the minimally invasive techniques are available. Thus, the mode of surgery for gastric carcinoma will be widely accepted and rapidly developed worldwide.

Objective To explore the effect of Angiotensin Ⅱreceptor inhibitor on proliferation and apoptosis and cell cycle of human en-dometrial cancer cell line induced by estrogen.Methods Human endometrial cancer cells,ishikawa were cultured,and then treated with different concentrations of estrogen or saralasin.Cell proliferation was examined using MTT,and cell cycle and apoptosis were determined us-ing flow cytometry.Results Saralsin inhibited the proliferation of ishikawa cells.After treated with saralasin at 10 min after estrogen induc-tion,cycle was arrested at G1/G0 phase and S phase was reduced in ishikawa cell with significant difference between treatment group and control group.An increase in early apoptosis and late apoptosis occurred at 10min after treatment.Conclusion Saralsin inhibits endometrial cancer cell ishikawa proliferation,induces apoptosis and accumulation in G1/G0 phase in vitro.Therefore,saralsin may be helpful for the treat-ment of endometrial cancer.

After a description of the connotation and features of ubiquitous information society and the connotation and components of information literacy of medical staff in ubiquitous information society, the approaches were put forward for training and improving the information literacy of medical staff in ubiquitous information society.

BACKGROUND:The tissue structure of the affected arms of the breast cancer patients is seriously damaged after operation, which often causes the disorder of functional activity and directly affects the lives and work of Breast Cancer patients.OBJECTIVE: To promote the functional recovery of affected-side upperlimb in patients with breast cancer after operation by three-stage functional training and health guidance.DESIGN: Clinical observationSETTING: Department of Nursing, First Affiliated Hospital, China Medical UniversityPARTICIPANTS:Totally 168 patients,to be all female,aged from34 to72 years with the average of 49.65 years, diagnosed breast cancer and received operation in the First Affiliated Hospital of the China Medical University from May 2002 to May 2004, were recruited.METHODS:Self-training was performed on the upper-arm at the affectedtion ( one or two days after operation): Do active and passive exercises of Off-bed stage (3 to 14 days after operation): Do exercises of shoulder joint,hospital( 3 to 6 months), functional exercise and guidance training on the upper arm, 2 to 3 times per day , 15 to 20 minutes per time. Self-training effect of the patients was investigated through further consultation, once every 2 months after the self-training.cises status and the abnormal status of their affected arms of the patients.RESULTS :Totally 168 patients completed the study,all their date was enbetter recovery with their affected arms and could do some simple work 75.0% (126/168)of the patients persisted in the functional training of their affected arms over half a year after they discharged from the hospital;25.0% (42/168)of the patients had different degrees of lymphatic edema of the affected arms.CONCLUSION:We have got an obvious effect in the aspects of strengthening the guidance of the functional training of their affected arms of the breast cancer patients and telling the patients and their family members the significance of persisting in training their main points of self nursing of their affected arms.

Objective To investigate the effects of different body temperatures on the neuromuscular block induced by different doses of cisatracurium in rabbits. Methods Seventy-two healthy New Zealand white rabbits of both sexes weighing 2.0-2.2 kg were randomly divided into 3 groups (n=24 each): hypothermia group (L), normothermia group (N) and hyperthermia group (H). The rectal temperature was set at 34.5℃, 38.5℃ and 41.8℃ in group L, N and H respectively. Each group was further divided into 4 subgroups (n=6 each) receiving intravenous cisatracurinm 0.33, 0.66, 0.99 and 1.32 mg/kg respectively after rectal temperature was stabilized for 20 min. The animals were anesthetized with iv 20% methane 1 g/kg, tracheostomized and mechanically ventilated (VT 12 ml/kg, RR 60 bpm, I:E = 1:2;FiO2 100% ). TOF was monitored. The onset time, the duration of action (from the end of cisatracurium injection to the recovery of T1 to 5%, 25% and 95% of control height) and recovery index (recovery of T1 from 25% to 75% of control height) were recorded. MAP, HR and rectal temperature were recorded at 5 min before alteration of the body temperature, at 2 min before and 5, 10, 30, 60 and 90 min after administration of cisatracurium. Results (1) With the same dose of cisatracurium the onset time and duration of action were significantly shorter in group H, longer in group L and recovery from N-M block faster in group H, slower in group L as compared with group N. (2) At the same body temperature the onset time was significantly shortened and the duration of action and recovery were significantly prolonged as the dose of cisatracurium increased. (3) There was significant difference in the effect of interaction between different doses of cisatracurium and different temperatures on the onset time. (4) With the same dose of cisatracurium MAP was significantly decreased in group H, increased in group L, while HR was significantly increased in group H, decreased in group L. Conclusion The neuromuscular blocking effect of cisatracurium is decreased when the body temperature is increased and vice versa. The neuromuscular blocking effect of cisatracurium (0.33-1.32 mg/kg) is dose-dependent at the same body temperature. There is interaction between the two factors.

[Summary] Cardiovascular disease ,diabetic nephropathy and diabetic retinopathy are common complications of diabetes ,and are the significant reason of cardiovascular mortality ,end-stage renal disease ,and blindness in adults patients with type 2 diabetes mellitus. At present, the researche on the pathogenesis of diabetic complications mainly focus on oxidative stress and chronic inflammation. In addition, a large number of studies have pointed out that bilirubin has antioxidant and anti-inflammatory effects. Therefore, bilirubin and diabetic complications are closely linked.

OBJECTIVE:To provide information for diversified operation of Chinese pharmaceutical retail chain enterprises.METHODS:By means of introducing the concept of commodity management,its effective application in Chinese pharmaceutical retail chain enterprises was analysed.RESULTS&CONCLUSION:Chinese pharmaceutical retail chain enterprises should apply commodity management theory to searching the mode of diversified operation,for improving net sales and market competition ability.

OBJECTIVE:To discuss about the management of Chinese pharmaceutical retail commerce METHODS:According to the analysis of the operation models and existing problems of Chinese pharmaceutical retail commerce,this paper brings forward concrete management strategy RESULTS & CONCLUSION:Chinese government and pharmaceutical retail enterprises should adopt effective management strategy to promote development of Chinese pharmaceutical retail commerce

OBJECTIVE:To provide the concept of management of circulation of commodities for Chinese pharmaceutical retail chain enterprises METHODS:According to the concept of management of circulation of commodities,to analyze its application in Chinese pharmaceutical retail chain enterprises RESULTS &CONCLUSION:Chinese pharmaceutical retail chain enterprises should search a mode of management of circulation of commodities which is appropriate for self-development to promote market competition ability

OBJECTIVE: To discuss the measures for development of pharmaceutical retail chain enterprises in China after access to WTO.METHODS: Practical developing measures were put forward by way of analysing the existing problems in pharmaceutical retail chain enterprises in China .RESULTS: & CONCLUSION:China s pharmaceutical retail chain enterprises should take the following measures perfecting relevent laws and regulations, deciding rational organization and clarifying the post responsibility, extending the business scale of chain stores, bringing in qualified personnel and training staff members, en-hencing the management of storage and delivery centre and intensifying the management of chain drugstores.