Abstracting and Indexing as Topic ; Medicine, Chinese Traditional ; Terminology as Topic ; Translations

Objective Study the effect of chlorogenie acids(CHA)on insulin resistance in obese rats induced by high‐fat diet . Methods We induced the obese rat model by feeding high‐fat diet ,obese rat model were divided into 4 groups:model group ,piogli‐tazone group(4 .5 mg/kg) ,CHA large dose group and group ,and finally determinated the levels of glucose tolerance ,serum insulin , serum lipid profiles and others .Results CHA showed a higher anti‐obesity activity with lower rate of increase of obese rats′body weights ,reversingglucose intolerance induced by high‐fat diet ,ameliorating the hyperinsulinemia ,decreaseing the levels of TG and TC ,and increase liver glycogen and muscle glycogen level compared with other group which treated with high‐fat diet .And in‐creased HOMA‐ISI ,decreased HOMA‐IR .Conclusion CHA can ameliorate the symptoms of insulin resistance in obese rats ,which mechanism may be related with CHA can stimulate glucose uptake and utilization by peripheral tissues ,and decrease the the serum levels of FFA ,decrease oxygen stress ,prevent and cure the injury induced by lipid peroxidation .

OBJECTIVE:To investigate the effects of application timing of carboporst tromethamine on postpartum hemor-rhage and hemodynamics of cesarean section women with centralplacenta previa. METHODS:Totally 138 parturient women with central placenta previa selected from our hospital during Jan.-Dec. 2015 were divided into observation group and control group ac-cording to random number table,with 69 cases in each group. Both groups received cesarean section. Control group was given Car-boporst tromethamine injection 250 μg on uterine body after the delivery of placenta. Observation group was given Carboporst tro-methamine injection 250 μg on corpora uteri immediately after umbilical cord cutting. The operation duration,intraoperative and postoperative blood loss were observed in 2 groups. The preoperative and postoperative 24 h hemodynamic index,coagulation func-tion and corpora uteri were compared between 2 groups. RESULTS:The operation duration of observation group was significantly shorter than control group;intraoperative blood loss and 24h blood loss of observation group were significantly less than control group,with statistical significance(P<0.05). There was no statistical significance in preoperative hemodynamic index and coagula-tion function index between 2 groups before surgery(P>0.05). 24 h after surgery,SBP,DBP,MAP,FIB and D-D of 2 groups were decreased significantly,while HR of them were increased significantly;the observation group was significantly better than the control group,with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR (15.94% vs. 13.04%) between 2 groups (P>0.05). CONCLUSIONS:Carboporst tromethamine after omphalotomy via uterine body helps to shorten the operation time,reduce intraoperative blood loss,maintain hemodynamic indexes stable and improve coagulation func-tion of cesarean section women with central placenta previa ,with good safety.

OBJECTIVE:To observe the efficacy and safety of atorvastatin in the treatment of hypertension with unstable angi-na. METHODS:80 patients with hypertension with unstable angina were randomly divided into control group and treatment group. All patients were given anti-platelet aggregation and other conventional treatment;based on it,control group was orally treated with Amlodipine besylate tablet 5 mg,once a day+Metoprolol tartrate controlled-release tablet 25 mg,twice a day+Isosorbide dini-trate injection 10 ml by intravenous infusion,twice a day;treatment group was additionally treated with Atorvastatin calcium tablet 20 mg,orally,qd. 3 months was a treatment course,and it lasted 6 courses. Clinical efficacy,and systolic blood pressure,diastol-ic blood pressure,angina frequency and duration,changes of TC,TG,LDL,HDL levels before and after treatment and adverse reac-tions in 2 groups were observed. RESULTS:Total effective rate in treatment group was significantly higher than control group,the difference was statistically significant(P<0.05). After treatment,systolic blood pressure and diastolic blood pressure in 2 groups were significantly lower or shorter than before,the difference was statistically significant(P<0.05),however,there was no signifi-cant difference between 2 groups(P>0.05);angina frequency and duration were significantly lower than before,and treatment group was lower than control group,TC,TG and LDL in treatment group were significantly lower than before and control group, HDL was higher than before and control group,the differences were statistically significant(P<0.05),there was no significant dif-ference between before and after treatment in control group(P>0.05). There was no significant difference in the adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on the conventional treatment, atorvastatin can effectively reduce the long-term angina frequency and duration of patients with hypertension with unstable angina,improve the ischemia myocardial and reduce the lipid levels with good safety.

Objective To investigate the risk factors for carotid artery atherosclerosis in young and middle-aged patients with ischemic stroke and the effect of serum lipoprotcin(a) [(Lp (a)] level on young and middle-aged patients with ischemic stroke.Methods Patients with ischemic stroke between the ages of 18 to 55 were enrolled.Carotid artery ultrasonography was used to evaluate the degree of carotid artery atherosclerosis,and the concentrations of serum total cholesterol,triglycerides,high density lipoprotein cholesterol,low density lipoprotein cholesterol,very low density lipoprotein cholesterol,apolipoprotein A1,apolipoprotein B and Lp(a) were detected.According to the results of carotid ultrasound,the patients were divided into groups of without atherosclerosis,plaque without stenosis,and carotid artery stenosis.The demographic and clinical features were compared among the 3 groups.Multivariate logistic regression analysis was used to identify the independent risk factors for carotid artery atherosclerosis in young and middle-aged patients with ischemic stroke.Results A total of 106 patients with ischemic stroke (n =50 in the without atherosclerosis group,n =44 in the plaque without stenosis group,n =12 in the carotid artery stenosis group) were enrolled in the study.The constituent ratios of age (45.98 ±7.12,50.07 ±4.79,and 50.92 ± 1.83 years,respectively; F =7.169,P =0.001),hypertension (26.0％,47.7％ and 58.3％,respectively; x2 =6.862,P =0.032),diabetes mellitus (22.0％,45.5％ and 66.7％,respectively; x2 =10.729,P =0.005),hyperlipidemia (24.0％,40.1％ and 75.0％,respectively; x2=11.372,P=0.003) and smoking (34.0％,61.4％ and 75.0％,respectively;x2 =10.93,P=0.006),as well as the serum high-density lipoprotein cholesterol (1.03 ± 0.26,0.95 ± 0.26 and 0.76 ± 0.08 mmol/L,respectively; F=5.882,P =0.004) and Lp (a) (0.108 ± 0.044,0.155 ± 0.028 and 0.200 ± 0.011 g/L,respectively; F =41.556,P =0.000) levels had significant differences in the 3 groups.Multivariate logistic regression analysis showed that age ＞ 48 years (plaques without stenosis:odds ratio [OR] 2.89,95％ confidenee interval [CI] 1.20-6.96,P =0.018; carotid artery stenosis:OR 4.43,95％ CI 1.19-16.57,P =0.027),hypertension (plaque without stenosis:OR 2.60,95 ％ CI 1.09-6.18,P =0.031; carotid artery stenosis:OR 3.99,95％ CI 1.08-14.77,P =0.039),diabetes (plaque without stenosis:OR 2.96,95％ CI 1.21-7.23,P=0.018; carotid artery stenosis:OR 7.09,95％ CI 1.79-28.02,P =0.005),hyperlipidemia (plaque without stenosis:OR 2.19,95％ CI 0.91-5.31,P =0.082; carotid artery stenosis:OR 9.50,95％ CI 2.21-40.86,P =0.002),smoking (plaque without stenosis:OR 3.08,95％ CI 1.33-7.16,P =0.009; carotid artery stenosis:OR 5.82,95％ CI 1.39-24.38,P =0.016),and Lp (a) (plaque without stenosis:OR 4.38,95％ CI 1.76-10.90,P=0.001; carotid artery stenosis:OR 12.80,95％ CI 2.73-52.67,P =0.001) were the independent risk factors for carotid artery atherosclerosis in young and middle-aged patients with ischemic stroke.Conclusions Age,smoking hypertension,diabetes and Lp(a) were the independent risk factors for carotid artery atherosclerosis in young and middle-aged patients with ischemic stroke.

Carefully evaluation of cardiovascular function in children with septic shock is the basis of appropriate therapy.Clinical methods of cardiovascular function evaluation include clinical manifestation,hemodynamic momtoring and laboratory test of tissue oxygenation.Evaluation of cardiovascular function should combine all results from different methods and should be dynamically monitored with the development of septic shock.

Objective: To investigate the impact of levosimendan on mortality in patients with severe heart failure (HF) by Meta-analysis. Methods: We search the PubMed, EMBASE and Cochrane Central Registry of cardiovascular disease to identify all randomized impact of levosimendan vs other medications. The document retrieval was from the establishment of each database until 2014-07. The literatures were taken based on Jadad scale standard and the qualified control study was used without dose and time restrictions by Rev Man 5.2 soft ware, and a total of 37 articles with 4470 patients were finally enrolled for Meta-analysis. Results: Compared with controlling medications, levosimendan could decrease the mortality in patients with cardiac disease caused severe HF (RR: 0.85; 95% CI 0.75-0.97;P=0.02), and cardiac surgery caused severe HF (RR: 0.49; 95% CI 0.28-0.85;P=0.01). Compared with dobutamine, levosimendan could reduce the mortality in patients with severe HF (RR: 0.84; 95% CI 0.73-0.99;P=0.02) and severe ischemic HF (RR: 0.85; 95% CI 0.73-0.99;P=0.04). Conclusion: Levosimendan may reduce the mortality in patients with severe HF caused by cardiac disease, cardiac surgery and ischemic cardiac injury.

Cardioplegic (and organ preservation) solutions were initially designed to protect the myocardium (cardiac myocytes) during cardiac surgery (and heart transplantation). Due to the differences between the cardiac myocytes and vascular (endothelial and smooth muscle) cells in structure and function, the solutions may have adverse effect on coronary vascular cells. However, such effect is often complicated by many other factors such as ischemiareperfusion injury, temperature, and perfusion pressure or duration. In evaluation of the effect of a solution on the coronary endothelial function, a number of points should be taken into consideration. First, the overall effect on endothelium should be identified. Second, the effect of the solution on the individual endothelium-derived relaxing factors (nitric oxide, prostacylin, and endothelium-derived hyperpolarizing factor) must be distinguished. Third, the effect of each major component of the solution should be investigated. Fourth, the effect of a variety of new additives in the solution may be studied. In the last decades, we have focused our research on the endothelial function during open heart surgery and have for the first time found that high potassium concentration impairs the EDHF-mediated function. This review attempts to discuss the above issues based on available literature in order to provide information for further development of cardioplegic or organ preservation solutions.

Mechanical ventilation is an important life support method.Correct parameter adjustment of mechanical ventilation depends on assessment of Patient's respiratory and the effectiveness of mechanical venfilation.Blood gas monitoring is the most important way to assess the effectiveness of mechanical ventilation.Guidance of blood gas monitoring in parameter adjustment of mechanical venfilation is the key of successful mechanical ventilation.

BACKGROUND: Previous research has indicated that bone marrow-derived mesenchymal stem cells had immunological regulation and hematopoiesis role. There were significant differences in immunological regulation and hemopoietic function between patients with aplastic anemia and normal cases. OBJECTIVE: To summarize the in vitro biological characteristics and its immune regulation defects of bone marrow-derived mesenchymal stem cells from patients with aplastic anemia.METHODS: A computer-based online search was conducted in PUMMED (1987-2009) and VIP database (1989-2009) with the key words of "mesenchymal stem cell, bone marrow" in both Chinese and English. There were 55 articles in total. Articles which were related to biological characteristics and its immune regulation defects of bone marrow-derived mesenchymal stem cells were included; however, duplicated articles were excluded. Finally, 32 articles were included, containing 3 reviews in English, 23 original articles in English, and 6 original articles in Chinese. RESULTS AND CONCLUSION: Bone marrow-derived mesenchymal stem cells had the capacities of high proliferation, self-renewal and multilineage differentiation; in addition they had the roles of supporting hematopoiesis, promoting implantation and hematopoietic reconstitution in vivo. Bone marrow-derived mesenchymal stem cells still had the effects of negative immune regulation and reducing the incidence of graft-versus-host disease (GVHD). Aplastic anemia correlated with hematopoietic stem cells in the pathogenesis of intrinsic defects in the proliferation or differentiation of hematopoietic microenvironment and immune system abnormalities and other related disorders. Bone marrow-derived mesenchymal stem cells of patients with aplastic anemia played an important role in the pathogenesis of this disease.