1.Study on the learning experience of undergraduate nursing students participating in the course of the general situation of foreign nursing
Yan ZHANG ; Yandan DUAN ; Jiange ZHANG ; Erhuan HAN
Chinese Journal of Practical Nursing 2015;31(33):2512-2515
Objective To understand the true feelings of the undergraduate nursing students after taking the elective course of the general situation of foreign nursing and provide reference for nursing higher education reform further.Methods The phenomenological qualitative research method was used and face to face in-depth interview was taken on 10 sophomore and 6 junior undergraduates about their feelings after taking the course of the general situation of foreign nursing.The interview data were sorted, analyzed and refined.Results The general situation of foreign nursing had aroused the yearning of nursing students on multinational nursing, deepen the cognition of nursing students on nursing specialty and also promoted the nursing students' perception of humanistic spirit.Conclusions The narrative educational which the teachers used in this course improves the professional cognition of nursing students.Situational case analysis is helpful to cultivate cultural sensitivity of students.The assessment method, personal reflection report & group cooperation, helps strengthen nursing students to rethink their own professional faith.
2.The genetic association between nonalcoholic fatty liver disease and type 2 diabetes mellitus in different body mass index categories: A bidirectional Mendelian randomization study
Haoxin DUAN ; Yuyong JIANG ; Tingyu WU ; Feixiang XIONG ; Yandan JIANG ; Qin ZHANG ; Saisai ZHAO ; Hao YU
Journal of Clinical Hepatology 2024;40(10):1992-1999
ObjectiveTo investigate the genetic association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) using bidirectional two-sample Mendelian randomization (MR), as well as the causal relationship between NAFLD and T2DM across different body mass index (BMI) categories. MethodsThe data were derived from genome-wide association studies conducted in European populations, with a sample size of 32 941 cases for NAFLD, 312 646 cases for T2DM, and 681 275 cases for BMI. The univariate and multivariate MR methods were used to assess the bidirectional causal relationship between NAFLD and T2DM in the general population and across different BMI subtypes. The methods of inverse-variance weighting, MR-Egger regression, constrained maximum likelihood and model averaging, and weighted median were used to conduct the MR analysis, and MR-Pleiotropy Residual Sum and Outlier, radial MR, the MR-Egger intercept method, and the Cochrane Q test were used for sensitivity analysis. ResultsThe univariate MR analysis revealed a bidirectional causal relationship between NAFLD and T2DM in the general population (forward analysis: odds ratio [OR]=9.75, 95% confidence interval [CI]: 2.57 — 37.00, P<0.001; reverse analysis: OR=1.01, 95%CI: 1.00 — 1.01, P<0.01). After adjustment for BMI, the multivariate MR analysis showed that the causal relationship between NAFLD and T2DM remained significant in the general population (OR=33.12, 95%CI: 7.57 — 144.95, P<0.000 1). The subgroup analysis showed a causal relationship between NAFLD and T2DM across all BMI subtypes (lean subgroup: OR=12.19, 95%CI: 3.35 — 44.40, P<0.001; overweight subgroup: OR=4.30, 95%CI: 1.69 — 10.92, P<0.01; obese subgroup: OR=1.67, 95%CI: 1.14 — 2.44, P<0.01). ConclusionThis study reveals the causal relationship between NAFLD and T2DM in the general population of NAFLD and across different BMI subtypes from a genetic perspective.