Child ; Cleidocranial Dysplasia ; diagnosis ; diagnostic imaging ; Humans ; Male ; Radiography

Clinical studies have shown that trastuzumab combined with chemotherapy can significantly improve survival in treatment of HER2-positive metastatic breast cancer as well as in the neoadjuvant and adjuvant therapy for HER2-positive early breast cancer. In patients with HER2-positive and hormone receptor-positive metastatic breast cancer, adding trastuzumab to endocrine therapy improves treatment efficacy. Resistance to trastuzumab may be reversed by incorporating other targeted therapeutic drugs. Patients can still benefit from continuing trastuzumab after their disease progresses.

Aim To establish an animal model of uterine leiomyoma for pathogenesis research and drug screen analysis.Methods Guinea pigs were treated with estradiol benzoate 100 ?g?d~(-1),twice a week,by intramuscular injection for 12 weeks.After the animal were killed,the uteri were dissected out and ultrathin sections were obtained.Compare to that of human being,pathohistologic characteristics were observed under the microscope.Results The uteri treated with estrogen were proliferated and deformated.Uterine nodules were observed in many of the tested animals.According to the results of pathohistology,these cells demonstrate the features of smooth muscle-like cells.Conclusion The uterine leiomyoma induced by estrodiol in guinea pig is similar to that of human being.It has been suggested that the animal model is valuable for pathogenesis research and drug screen analysis,although it still needs more evidence to be demonstrated.

Adult ; Ear Canal ; pathology ; Ear Neoplasms ; Female ; Humans ; Neurofibromatoses

Cutaneous wound healing is a complicated multiatep process with numerous mediators that act in a network of activation and inhibition processes. Nonhealing chronic wounds decrease the quality of Life. Recombinant growth factors, currently used in clinic, fail to provide a sustained repair function at the wound due to their inadequate biological availability and transient half-time. Recent attention has focused on gene therapy, which might become a significant treatment modality for those wound healing pathologies refractory to other wound management approaches. This review discusses the potentials and limitations of current genetherapy for the treatment of wounds, current ongoing clinical trials, and possible future directions in this exciting field.

Cancer cells frequently share biological characteristics and energy metabolic processes distinct from normal cells. The specific metabolic phenotype was originally known as the Warburg effect. Researchers later discovered that cancer cells prefer to synthesize fatty acid de novo . Moreover, key enzymes involved in fatty acid synthesis and β-oxidation are overexpressed in tumor tissues, with low or without expression in normal tissues. Abnormal fatty acid metabolism is related to the survival and invasiveness of cancer cells, indicating that abnormal fatty acid metabolism provides the crucial components and energy sources of cancer cells. In recent years, the specific phenotype of abnormal fatty acid metabolism and the exploration of the role of this metabolic alteration in cancer biology and therapeutic strategies targeting the fatty acid metabolic pathways have become attractive focuses in cancer research. The role of active fatty acid metabolism in tumorigenesis and development, as well as the research progress in the development of the specific inhibitors, is reviewed in this paper.

[Objective]To sum up Mr. Zhu Xiankang’s clinical experience in treating children multiple tourette syndrome with nourishing kidney to soothe liver and relieving dizziness to remove sputum. [Method] By expounding the reason and mechanism, treating rules and formula of children multiple tourette syndrome, as wel as analyzing typical clinical cases, it expounds Pro. Zhu Xiankang ’s experience in treating the said disease with his method. [Re-sult] In his view, the disease owes to excessive five sensations, wind sputum accumulated inside, with mechanism of deficient kidney and hyperactivity of liver, wind sputum blocking col aterals, should take nourishing kidney to soothe liver and relieving dizziness to remove sputum as basic method;he applied revised Dingchou Decoction to treat 1 case of multiple tourette syndrome; after 3m, the un-automomous spasm disappeared gradual y, the patient had good appetite and sleep, al symptoms were relieved, and he was cured. [Conclusion] Mr. Zhu Xiankang ’s clinical experience in treating children multiple tourette syndrome has enlightenment to pediatrics clinic.

0.05)but a statistical difference between groups I and groups III(P

The development of formulas in the Ming Dynasty surpassed the previous dynasties in range and depth.The main achievements of formulas were not only the coming out of Puji Fang and Yifang Kao,but also the diversity of formulas nomenclature and variation,initial perfection of formulas classification and composition,continuous invention of new distinctive formulas,steady increment of remedy books and wide application of preparations.

OBJECTIVE:To discuss the influence of Shanghai Guiding Principles of Clinical Use of Antibiotics Implementing Rules(Trial)(named Implementing Rules for short) on prophylactic use of drugs in patients underwent general surgery operation.METHODS:In retrospective study,inpatients of general surgery department in our hospital from Sep.2006 to Feb.2008 were divided into 3 groups(Group 1:6 months before Implementing Rules issued;Group 2:0～6 months after Implementing Rules issued;Group 3:7～12 months after Implementing Rules issued).The utilization of antibiotics was analyzed as well as its rationality.RESULTS:A total of 1 308 cases were enrolled.The utilization frequency of antibiotics was 3 463.Less than half of cases met the indication of antibiotics while the rate of drug sensitivity test was 1.2%.The treatment courses of 3 groups were(3.4?4.3) d,(3.3?2.9) d and(3.1?3.0) d.The proportions of rational drug use were 36.5%,35.1% and 40.7%.But the selection of antibiotics,drug combination and ADR report were not significantly improved.CONCLUSION:The issue of Implementing Rules has promoted the rational use of antibiotics in general surgery department.Further training and monitoring are needed.