During the translation process, aminoacyl tRNA enters the ribosome, decoding the codon on the mRNA and brings the mRNA moving forward towards the 5′ direction of mRNA, until the de-acylated tRNA leaves the ribosome, it moves through the ribosome in one direction. Recently, with the finding and identification of the highly conserved protein LepA, a new kind of tRNA movement inside the ribosome, namely the back-transloation of the tRNAs and mRNA in the direction of mRNA 3′ is discovered. With the in-depth research, the physiological meaning behind the back-translocation for the translational efficiency and fidelity has been studied.

Objective:To study the formation of lesions,caused byHIFU with SonoVue,in liver tissues containing blood vessels with the diameter of about 3mm.Methods:The livers of ten goats were insonicated linearly by Model-JC focused ultrasound tumour therapeutic system.The target regions contained blood vessels with the diameter of about 3mm,with or without SonoVue.24 hours after the insonication,the goats were executed with overdosage anesthetics.The length,width and thickness of the lesions were measured,then the necrosies volumes with and without SonoVue were compared.Results:When the depth was 30mm,and the target regions caotained large blood vessels,HIFU with SonoVue could form lesions effectively.There was difference of necrosis volumes between lesions with and without SonoVue,and the difference was significan(tP

Objective To analyze the fetal growth ,development and birth situation in umbilical artery absent end‐diastolic flow(AEDF) in late pregnancy .Methods The umbilical artery blood flow signals were detected by color ultrasonic diagnostic in‐strument .The fetal growth indexes and Apgar score at birth were compared between the normal umbilical artery group and the AEDF group .Results The occurrence rate of fetal growth and development less than the gestational age was significantly higher than that in the normal group ,moreover the occurrence rate of intrauterine stress was also obviously higher than that of the normal group .Conclusion Umbilical arterial AEDF in late pregnancy prompts the fetal intrauterine hypoxia and relatively slowly fetal grow th .

Ohjective To study the indications,clinical effect and complications of hysterectomy so as to im- prove therapeutic effect.Methods The clinical data involving 320 cases of hysterectomy in this hospital from 2000 to 2006 were reviewed,and the pathogenesis,operation mode,curative effect and post-operation complications were analysed.Results Patients who received hysterectomy due to benign gynecologic diseases were cured well cliniclly; those who received hysterectomy due to malignant gynecologic diseases or diseases with the tendency of malignant change were cured well in early stage but the effect was not so satisfactory in later stage.The operation mode was de- cided by considering the pathogenesis and individual difference.Conclusion For benign gynecologic diseases,hys- terectomy can be conducted with good effect after conservative treatment becomes ineffective.For malignant gyneco logic diseases,early treatment will bring good resuh,while late treatment will generate not so satisfactory effect.Indi- cations for operation should be controlled strictly for hysterectomy to guard against complications.

Objective To investigate the clinical advantages and safety profile of the combinational treatment of acute progressive cerebral infarction with aspirin,clopedogrel and atorvastatin.Methods 170 cases with acute progressive cerebral infarction were randomly divided into the treatment group and control group,85 patients in each group.Both two groups were initially treated with aspirin and atorvastatin.After excluding the possibility of hemorrhage, the treatment group additionally received clopedogrel,while the control group was treated with aspirin and atorvastatin. The difference in clinical efficacy was evaluated between before treatment and 7 days,14 days or 28 days after treatment by using the NIH Stroke Scale (NIHSS)and Barthel Index (BI).Results The NIHSS scores of the treatment group after 7d,14d and 28d were (12.52 ±3.25)points,(9.10 ±3.21)points and (6.87 ±2.85)points, which of the control group were (13.65 ±2.93)points,(10.73 ±3.41)points and (9.07 ±2.96)points respectively, the differences between the two groups were statistically significant(t =2.340,3.170,4.877,all P <0.05).The BI scores of the treatment group after 7d,14d and 28d were (35.26 ±11.18),(53.73 ±13.74)and (74.61 ±17.35), which of the control group were (31.98 ±9.12),(46.65 ±11.79 )and (63.87 ±15.73 )respectively,the differences between the two groups were statistically significant(t =2.131,3.752,4.456,all P <0.05).The overall effective rates of the treatment group after 7d,14d and 28d were 62.7%,79.5% and 94.0%,which of the control group were 51.2%,68.3% and 84.1% respectively.The differences of overall effective rates were statistically significant after 14d and 28d(χ2 =4.711,8.531,all P <0.05).Few reverse reactions were observed in both two groups.Conclusion Compared with the aspirin and atorvastatin therapy,combinational treatment of acute progressive cerebral infarction together with clopedogrel has a better efficacy,safety profile and significant promotion on neurological recovery.

Objective:To investigate the composition and clinical features of inpatients with congenital heart disease (CHD) complicated with pulmonary arterial hypertension (PAH) from a cardiovascular department.Methods: We retrospectively analyzed the clinical data of 238 PAH patients who were identified from 3 674 CHD inpatients in Changhai Hospital during Jan, 2001 to Jul, 2007.Results: Among the 3 674 CHD inpatients who were treated in our hospital in recent 6 years, 238 (6.48%) had PAH.PAH was found in 10.8% of patients with atrial septal defect (ASD), 2.81% of patients with ventricular septal defects (VSD), 5.57% of patients with patent ductus arteriosus (PDA), and 19.6% of patients with complex types.The mean age of patients was (45.6?17.7) years, with 49.6% of them being 40-60 years.Female patients accounted for 69.3% of the total.The composition of PAH patients was: ASD (62.6%), VSD(19.7%), and PDA(13.4%).The patients with VSD,PDA or other complex types were younger than those with ASD(P

Narrative medicine adds new elements for the development of medical humanistic education .It pro-vides a new perspective to re -examine the doctor -patient relationship .From medical humanities and narrative and narrative ability is medical students overall development reality needs two aspects analyzes the narrative ability training medical students is a new requirement , medical humanities education narrative medical practice signifi-cance is not only reflected in promoting the medical work of humanity , but also in the training process for medical students through the narrating ability .

The requirement for HCWs grows with the transfer of medical care model and increasing expectation of social population.This paper reviews the Psycho-social education in PUMC for 90 years and creates potential strategies for the Psycho-social education in long-term medical education program in China.

Objective To study the effect of rosiglitazone (RSG), the agonist of peroxisome proliferator activated receptor γ (PPARγ), on the proliferation and differentiation of rat osteoblasts and the related mechanisms. Methods The identification of rat primary osteoblasts was performed by alkaline phosphatase (ALP) staining and mineralized nodules. The 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay and p-nitrophenyl phosphate (PNPP) assay were used to observe the effects of different concentrations of RSG on proliferation and differentiation of the osteoblasts. The reverse transcription polymerase chain reaction (RT-PCR) were used to detect the expression of connective tissue growth factor (CTGF) mRNA. The effects of the different concentrations (0,1,2,5,10 and 20 μmol/L) of RSG on TGF-β1-induced CTGF mRNA expression in osteoblasts were detected. Results (1)Different concentrations of RSG could not change the proliferation of osteoblasts (P＞0. 05). (2)Compared with control group, all different concentrations of RSG could suppress ALP activity in osteoblasts (P＜0. 01 ). (3) RSG suppressed the osteoblats CTGF mRNA expression induced by TGF-β1 in a dose-dependent manner (P＜0. 01). Conclusions In vitro, RSG can inhibit the TGF-β1 induced rat osteoblasts CTGF mRNA expression. RSG may play a potential role in preventing the differentiation of the rat osteoblasts.

Objective: To explore the effect of health insurance on consumption for rural and urban households. Methods: Using empirical study with the method of quasi-social experiment. Results: Households with health insurance have more consumption than those without health insurance. The higher the coverage of family health insurance improves, the more effects medical insurance would encourage family consumption. Meanwhile, the marginal effect of health insurance on rural households ’ consumption is much bigger than that of urban households. Conclusion: Through enhancing households’ risk tolerance, health insurance reduces households’ precautionary saving motivation and impels to increase the current consumption.