Objective To application of solution focused approach in the functional gastrointestinal disorders.Methods 64 hospitalized clients with functional gastrointestinal disorders were randomly divided into the observation group and the control group with 32 cases in each group.We applied the normal nursing intervention to the control group,while applied the solution focused approach to the observation group.The anxiety and depression score,score of coping way and gastrointestinal symptoms were evaluated using t test.Results The scores of anxiety and depression,coping way and gastrointestinal symptoms were better in the observation group than those in the control group.Conclusions Adoption of solution focused approach can relieve FGID sufferers'negative emotion,such as anxiety and depression,increase sufferers' coping capacity and symptoms,which demonstrate pivotal significance for rehabilitation of functional gastrointestinal disorders.

BACKGROUND:Glutathione S-transferase can get rid of active oxygen and enhance organism's antioxidative capability.OBJECTIVE:To analyze the association between glutathione S-transferase P1-105 (GSTP1-105)genetic polymorphisms and human exercise capacity in the high altitude environment.DESIGN,TIME AND SETTING:A controlled analysis was performed in the PLA Institute of Physical Education in 2007.PARTICIPANTS:A total of 86 professional mountain climbers who had strong physical performance in the high altitude environment served as experimental subjects.An additional 90 healthy students randomly selected from the PLA Institute of Physical Education served as controls.METHODS:Blood sample was taken from 86 experimental subjects and 90 healthy controls for extraction of genome DNA.GSTP1-105 genetic polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism analysis.Distribution of GSTP1-105 alleles and genotypes were compared between experimental and control subjects.MAIN OUTCOME MEASURES:Distribution of GSTP1-105 genotype.RESULTS:Totally 3 GSTP1-105 genotypes were detected:homozygous genotype of the A allele (NA,also called wide type genotype),heterozygous genotype (NG),and homozygous genotype of the G allele (G/G).The frequency of the G allele and variant genotype (A/G+G/G)were significantly lower in the experimental than in the control subjects (P＜0.01).Variant genotype (A/G+G/G)was taken as an exposure factor,then OR=2.19 and 95% CI=1.16-4.13,indicating that in the high altitude environment,the exercise capacity in individuals with GSTP1-105 variant genotype was decreased by 1.19 times than that in individuals with GSTP1-105 wide type genotype.CONCLUSION:GSTP1-105 genetic polymorphisms correlate to human exercise capacity in the high altitude environment.Subjects with wide type genotype have exercise predominance.

China ; Evidence-Based Medicine ; methods ; Humans ; Orthopedics ; methods

Objective: To investigate the effect of prenatal tobacco and alcohol exposure on stature and neural development of offspring. Methods: Female mice were exposed to tobacco smoke and alcohol drink from D6 of pregnancy to parturition. The early physical development, neurobehavioral and antioxidative functions were measured in offspring mice. Results: Compared with control, offspring subjected to prenatal exposure showed significant reduced body and organ weights as well as reduced gestational body weight gain. It also resulted in remarkable prolonged neonatal reflexes and reduced motive, coordinative and locomotor activities. Step-down and Y-maze tests revealed marked destroyed memory and learning ability. Futhermore, MDA in offspring brain cytosol and mitochondria increased significantly and the activities of SOD, GSH-Px, CAT and GST were decreased. Conclusion: Prenatal tobacco and alcohol exposures interfere with the early physical and neural development in mice, probably related to decreased antioxidative functions.

Objective To assess the impact of parents' occupational class and intergenerational occupational mobility on children's mental health so as to provide evidence for improving health equity.Methods Chinese general social survey 2005 (CGSS2005) dataset was used for multivariate analysis of variance (MANOVA).Results The proportion of children whose father or mother was of lowerclass occupation was 59.0％ and 62.9％,respectively.When grew up,this figure dropped to 49.8％.Those whose father was in the higher-class occupational group reported better mental health status (F =1.449,P=0.015).Downward occupational class mobility experience also increased the risk of mental illness (F =3.050,P =0.048).Conclusion This study suggests an independent relationship between mental health and parents' occupational class and intergenerational occupational mobility.

Objective To investigate the efficacy of warfarin combined with urokinase in the prevention of deep venous thrombosis after hip replacement. Methods 58 patients undergoing hip replacement in our hospital from October 2014 to October 2016 were randomly divided into the observation group and the control group, 29 cases in each group. The control group were treated with oral warfarin, the observation group was treated with warfarin combined with urokinase, two groups of patients were treated for 14d, the incidence of lower limb deep vein thrombosis, follow-up statistics of two groups of patients within three months after operation, the diameter and blood rheology changes before and after weeks of treatment of lower extremity. Results During the treatment and follow-up of 14d patients in the control group, the incidence of deep venous thrombosis was 20.67% significantly higher than the observation group 3.45% (P<0.05); after treatment, the two groups of patients with lower limb circumference difference was significantly reduced (P<0.05), and the patients in the observation group the thigh circumference, calf circumference difference was significantly less than the control group (P<0.05); after treatment, the two groups of patients with high blood viscosity, low blood viscosity, plasma viscosity and hematocrit were significantly lower than those before treatment (P<0.05), and the indicators of the observation group were significantly lower than the control group (P<0.05). Conclusion Warfarin combined with urokinase can effectively prevent the formation of deep vein thrombosis of lower extremity after hip replacement, improve the hypercoagulability of patients and reduce the circumference of the lower extremity, so it is worthy of clinical application.

Objective To understand the quality of life of elders in the community of Shangqiu and analyze the affecting factors to provide a scientific evidence which could improve their quality of life.Methods The general questionnaire and World Health Organization Quality of Life Brief Evaluation From were used among 116 elders in two communities of Shangqiu.Results The quality of life of elders was in low level.The mainly factors that influencing the quality of life of elders in the community of Zhengzhou were age,education status,economic income,hobbies and interest,family relation,physical exercise.Conclusions The factors that influence the elders in community are various.To improve quality of life of elders,community workers should take relevant measures and encourage family members to participate in caring elders.

Cervical spinal canal tumors is not rare,accounting for about 15%of all spinal tumors. Due to the particularity of its anatomical location and the severity of operative complications, it is considered as a difficult point in spinal surgery. With the development of imaging medicine and various surgical techniques,many new theories and techniques have been developed. Its overall treatment effect is satisfactory, but the serious surgical complications not rare. This article reviews the progress in treatment of cervical spinal canal tumors, in order to provide a reference for the further improvement of cervical spinal canal tumors treatment .

Metabonomics is an important branch of system biology following the development of genomics, transcriptomics and proteomics. It can perform high-throughput detection and data processing with multiple parameters, potentially enabling the identification and quantification of all small metabolites in a biological system. It can be used to provide comprehensive information on the toxicity effects, toxicological mechanisms and biomarkers, sensitively finding the unusual metabolic changes caused by poison. This article mainly reviews application of metabonomics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous animals, and also illustrates the new direction of forensic toxicology research.
Animals ; Biomarkers ; Forensic Toxicology/methods* ; Humans ; Metabolomics/methods*

OBJECTIVE: To explore the method for the objective evaluation of single limb function after in- jury in forensic medical practice. METHODS: The score of activities of daily living (ADL) were graded for a single limb function after injury from 47 cases. All cases were simultaneously evaluated using the different methods including Fugl-Meyer motor function assessment (FMA), weighting, look-up table (LUT). The correlation were compared between ADL and the other three methods. RESULTS: Injured part and the score using the three methods were correlated with ADL score (P < 0.05). The correlation coeffi- cient (|r| value) showed highest using LUT method, and lowest using FMA method. CONCLUSION The loss function of limb is affected by the injuried parts. The methods of FMA, weighting and LUT show a good accuracy for evaluating the limb function after injury and the correlation presents higher using LUT method.
Activities of Daily Living ; Disability Evaluation ; Extremities/injuries* ; Forensic Medicine/methods* ; Humans