Nanoliposomes are used as a delivery vehicle of drugs or genes in the targeted treatment of cancer and in gene therapy respectively. These treatment methods have shown better therapeutic effects when compared with conventional therapeutic methods. Nanoliposome are also being used to deliver imaging contrast agents in the targeted imaging of cancer cells and angiogenesis, which can result in better monitoring of patients' response to therapy.

The utility of anticoagulants is a significant content of total quality management(TQA)of clinical laboratory.The accurate results of laboratory investigations are closely correlated witll appropriate application of blood anticoagulants.The paper reviews the utility field and effects on investigation result of different anticoagulants,and it also raises the current problems of using anticoagulants and Dut forward corresponding solutions.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Myasthenia Gravis ; therapy

Acupuncture Therapy ; China ; Health Services Accessibility ; Humans ; Public Health

Acupuncture ; education ; trends ; Biomedical Research ; trends ; China ; Humans ; Philosophy

Abstract?AIM: To comparatively analyze the efficacy and clinical value of cutting frontal muscular slap or not during frontalis aponeurosis flap suspension in treating congenital severe ptosis.?METHODS: Clinical data of 44 children ( 54 eyes ) with congenital severe ptosis treated in our hospital from May 2013 to October 2015 was retrospectively analyzed. Children included were divided into two groups according to the different ways of operation, observation group ( cutting frontal muscular slap ) and control group ( without cutting frontal muscular slap ) , 22 cases ( 27 eyes ) in each group. The general information, postoperative follow-up, eyelid closure and complication occurrence in two groups were compared.?RESULTS: The general information of the two groups had no statistical difference (P>0.05).After 1, 6mo, the cosmetic correction rate, the rate of overcorrection, and the rate of under correction in two groups had no statistical difference (P>0.05), but the activity of upper eyelid in observation group was bigger than that in control group (P<0.05).After 1, 6mo, the incomplete closure in two groups had no statistical difference ( P>0.05 ) , but eyelid fissure height in natural closed eyelids in control group was higher than that in observe group ( P<0.05 ).After 1mo, 2 eyes in control group were with abnormal feelings in frontal part, and 3 eyes in observation group.After 6mo, 2 eyes in control group were with abnormal feelings in frontal part, and 3 eyes in observation group.There were no complications such as exposure keratitis, eyelid margin deformity, infection, hematoma, and diplopia in two groups.?CONCLUSION: The total therapeutic effects of two different surgery procedures in treating severe congenital ptosis are quite similar.The surgery with cutting frontal muscular slap could improve the activity of upper eyelid and postoperative eyelid closure.

Objective To explore the correlation between the recurrence rate of the elderly patients with lacunar infarction and the risk factors including blood pressure, blood glucose, total cholesterol, triglycerides,low density lipoprotein cholesterol values, high-density lipoprotein cholesterol and other. Methods 207 over 60 years old patients with lacunar infarction occurred the first time were included in the study. All patients were followed up two years to assess the relapse rate and the risk factors of the patients with lacunar infarction. Results 207 cases of elderly patients with lacunar infarction complicated with hypertension,type 2 diabetes and hyperlipidemia were 148 cases,22 cases,7 cases respectively, and the recurrence rates of three groups were 8.78%, 18.18%, 14.29% respectively;The patients complicated with hypertension and 2 type diabetes were 6 cases,and the recurrence rate was 34.62%;The patients without hypertension,type 2 diabetes and hyperlipidemia were 4 cases,and the recurrence rate was 0%. In two years,27 cases of lacunar infarction recurred,and the recurrence rate was 13.04%. Conclusion Hypertension,type 2 diabetes,hyperlipidemia could also be considered as the high-risk predictor factors for the recurrence rate of the elderly patients with lacunar infarction.

Objective To evaluate the performance of microRNA‐21(miRNA‐21) for the diagnosis of esophageal cancer .Meth‐ods Published literatures ,investigating the diagnostic performance of miRNA‐21 in esophageal cancer ,were screened .QUADAS‐2 software was used to evaluate the quality of related literatures .All analysis about relevant data was accomplished by using Meta‐DiSc statistical software .The sensitivity ,specificity ,positive likelihood rate ,negative likelihood rate and diagnostic odds ratio were pooled ,using corresponding effects models .Results Four studies met the inclusion criteria ,accumulating 202 esophageal cancer pa‐tients and 124 healthy controls .The summary estimates for miRNA‐21 in the diagnosis of esophageal cancer were with diagnostic sensitivity of 0 .85 and specificity of 0 .65 .The area under summary receiver operating characteristic curve was 0 .817 4 .Conclusion miRNA‐21 might be a novel biomarker for the diagnosis of esophageal cancer ,and could be used for screening and auxiliary diag‐nosis of esophageal cancer .

Objective To investigate the value of preoperative total abdominal spiral CT scan in evaluating the staging of ovarian cancer.Methods Clinical data of 42 patients with ovarian cancer undergoing total abdominal spiral CT were collected.The CT images were retrospectively analyzed,and the CT staging and surgical pathologic staging were compared.Results Multi-slice spiral CT on ovarian cancer invasion and metastasis has high accuracy of diagnosis.The diagnostic accuracy of this group for direct tumor invasion,peritoneal metastasis,lymph node metastasis and ascites was 66％-100％.The correct preoperative staging were 34 cases:6 cases in stage I,6 cases in stage Ⅱ,17 cases in stage Ⅲ,5 cases in stage Ⅳ,and the staging accuracy of 80.9％.Conclusion Total abdominal multi-slice spiral CT examination is of great value in preoperative staging of ovarian cancer.