Humans ; Integrative Medicine ; methods ; Medicine, Chinese Traditional ; methods ; Neoplasms ; prevention & control ; therapy ; Quality Control ; Research Design

Objective To understand the learning needs of nursing students for nursing English in senior high vocational school.Methods A survey was carried out among 982 three-year nursing students in grade 2007-2009 in Cangzhou medical college by questionnaire.The data collected were analyzed using descriptive statistics with SPSS 17.0.Results Most students (93.0％) believed that nursing English was important and had a strong desire for most English skills,especially speaking and listening ability.They (90.7％) expected nursing teachers to take charge of or participate in teaching work and some students (30.6％) were dissatisfied with teaching material.They depended on teachers' instruction and preferred learning in real situations.Conclusions Nursing students in senior high vocational school have strong needs for nursing English,but there is a gap between current teaching situation and learning needs,which the course designers and teachers should take into full consideration in order to make the teaching more effective.

Viral myocarditis can cause severe myocardial injury and even acute heart failure, then evolve into dilated cardiomyopathy, known as inflammatory cardiomyopathy. Immune reaction plays a key role in the transformation from viral myocarditis into dilated cardiomyopathy, including virus RNA continuous replication,immune-mediated injury, cellular apoptosis, other cellular immune response , myocardial antibodies and other humoral immune response. In the clinical treatment, besides anti-heart failure and cardiac nutrition, the use of ribavirin, α1-receptor blockers, β-receptor blockers, calcium channel blockers, angiotensin converting enzyme inhibitors and spironolactone should be emphasized.

Objective To recommend the appropriate retrieval tools for scientific researchers and improve their re-trieval efficiency by comparatively analyzing the retrieval results from PubMed and Embase .com.Methods Eight retrieval terms from different subjects were used to retrieve PubMed and Embase .com by subject headings and basic retrieval methods than can automatically transfer their function .Results Six different results were retrieved from PubMed and Embase.com with 8 retrieval terms.Conclusion The recall ratio is higher in Embase.com than in PubMed when they are retrieved by subject headings while the accuracy ratio is higher in PubMed than in Embase . com when they are retrieved by basic retrieval methods than can automatically transfer their function although error transformation occurs in both PubMed and Embase.com.

Reference service is one of the key tasks in library.The current situation of reference service in library and its problems were analyzed from the need of readers, and the problems to which attention should be paid were pointed out from its convenience and time-effectiveness .

With the development of clinical pharmacy in hospital,the demand for pharmacy intravenous admixture services (PIVAS) has been gradually increased.By being built inside the pharmacies,PIVAS of this hospital has created a full range of integrated pharmacy service platform.With independent research and development of information management system,innovative design of the modules and equipments based on the concept of internet of things,and integration of artificial and computerized checking,PIVAS of this hospital has formed a system of prevention and control chain,it has been deepening the connotation of clinical pharmacy services,and providing higher quality pharmacy services to clinical drug using.

Objective To systematically evaluate the effectiveness of using gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU.Methods The randomized controlled trials (RCTs) on the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU were collected through the databases such as the China National Knowledge Infrastructure (CNKI),China Scientific Journal Database by VIP (VIP) and Wanfang Database.The quality of studies was critically appraised and data were extracted by two reviewers independently.Meta-analysis was conducted for the included studies.Results Eleven RCTs involving 1 337 patients were included.Meta-analysis showed that the application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU could reduce ventilator-associated pneumonia (VAP) incidence rate[RR=0.54,95％CI(0.44-0.65),P ＜ 0.01],shorten the duration of mechanical ventilation [mean differences(MD)=-2.38,95％CI(-2.69--2.07),P ＜ 0.01] and length of ICU [MD=-3.66,95％CI (-5.45--1.87),P ＜ 0.01],but the mortality rate was not statistically significant [RR=0.37,95％CI (0.11-1.26),P ＞ 0.05].Conclusions The application of gargle solution Chlorhexidine Gluconate for patients with mechanical ventilation in ICU is safe and effective.

Objective To explore the feasibility and importance of active monitoring of vancomycin‐related nephrotoxicity .Meth‐ods During July 2010 to July 2013 ,a total of 139 cases of inpatients received vancomycin through intravenous injection were en‐rolled in this study .The adverse drug reaction active monitoring and early warning system were utilized to evaluate patients with vancomycin positive events .Results Among the 139 cases of patients ,there was 9 cases of patients with renal damage .The inci‐dences of compensatory stage of renal insufficiency ,decompensatory stage of renal insufficiency ,renal failure stage and end‐stage re‐nal failure were 44 .44% ,22 .22% ,22 .22% and 11 .11% respectively .The positive warning rates when serum creatinine level was above 133 μmol/L ,increased by 50% compared with the baseline ,increased with 44 μmol/L based on the baseline were 55 .56% , 22 .22% and 22 .22% respectively ,and those positive warning rates in artificial relevance evaluation were 19 .18% ,19 .18% and 56 .54% respectively .Conclusion It is necessary to individualize utilization of vancomycin according to patients′s condition .

Objective To investigate the distribution of camptothecin(CPT),tryptophan synthase(TSB),and tryptophan decarboxylase(TDC) in Camptotheca acuminata seedlings.Methods The CPT content,TSB and TDC activities in different organs of C.acuminata seedlings subjected to different nitrogen forms treatments by sand culture in greenhouse were determined by HPLC.Results The CPT content in the young leaves of C.acuminata seedlings with different N-forms was significantly higher than that in other organs(P

Aim To investigate the effects of curcumin on expression of HIF-1? in human hepatocellular carcinoma BEL-7402 cells.Methods Different concentrations of 0,2.5,5,10,15 and 20 ?mol?L~(-1) curcumin-treated human hepatocellular carcinoma BEL-7402 cells were cultured under hypoxia for 6 hours.The cell proliferation and cell viability were assayed by WST-8 and the trypan blue dye exclusion method.The expression level of HIF-1? in human hepatocellular carcinoma BEL-7402 cells was checked by RT-PCR and Western Blot;0,10 ?mol?L~(-1) curcumin,10 ?mol?L~(-1) MG-132,and 10 ?mol?L~(-1) curcumin +10 ?mol? L~(-1) MG-132-treated human hepatocellular carcinoma BEL-7402 cells were cultured under hypoxia for 6 hours.The protein expression level of HIF-1? protein in human hepatocellular carcinoma BEL-7402 cells was checked by Western Blot.Results ① No significant difference was found in the cell proliferation rate and cell viability between control and different concentrations of curcumin.② Curcumin can down-regulate the expression of HIF-1? protein with the increasing concentrations.③ the effect of curcumin on expression of HIF-1?mRNA had no significant difference between control and different concentrations.④ MG-132 can reverse the curcumin-mediated decrease of HIF-1? protein.Conclusion Inhibitory effect of curcumin on expression of HIF-1? in human hepatocellular carcinoma BEL-7402 cells was acted through posttranscriptional mechanisms and the proteasome pathway.