Objective To evaluate the efficacy of laparoscopic surgery combined with sanjiezhentong capsule for endometriosis. Methods Thirty-three cases of endometriosis who accepted conservative surgery were divided into 2 groups: 19 cases accepted treatment of sanjiezhentong capsule (sanjiezhentong capsule group, infertile patients were 9 cases) and 14 cases accepted goserelin (goserelin group, infertile patients were 8 cases ). The treatment of two groups were given drugs on the first day of menstrual onset after operation for 3 months. The effect, side effect and pregnant was compared after treatment. Results The total effective rate of sanjiezhentong capsule group was 73.7%( 14/19) and in goserelin group was 78.6%( 11/14), there had no statistically significant (P> 0.05). The pregnancy rate of secondary infertile patients in sanjiezhentong capsule group was 55.6%(5/9) and in goserelin group was 62.5%(5/8)(P> 0.05). The side effect was lower in sanjiezhentong capsule group than that in goserelin group. Conclusion Sanjiezhentong capsule is a safe and effective drug in treating post-operative endometriosis.

OBJECTIVE:To investigate the characteristics of ADR induced by psychotropic drugs in children and adolescent of our center,and to provide reference for clinical drug use. METHODS:ADR induced by psychotropic drugs in children and adoles-cent reported by our center from 2005 to 2015 were investigated and analyzed retrospectively. RESULTS:A total of 177 ADR were collected,of which the most cases were induced by antipsychotic drugs as risperidonal,olanzapine and quetiepine. The most com-mon ADR were central and peripheral nervous system disorders(117 cases,37.86%),followed by endocrine disorder(35 cases, 11.32%),heart rate and rhythm disorders(32 cases,10.35%)and liver and biliary system disorders(17 cases,5.50%). By the relative titer of haloperidol,most of ADR were induced by haloperidol with dose of 4 mg,6 mg and 8 mg once a day(34,29 and 53 cases). Most of cases occurred within a week(94 cases,53.11%). CONCLUSIONS:To develop and strengthen clinical applica-tion and ADR monitoring of psychotropic drugs in children and adolescents should be regarded as the key to ensure drug use safety.

OBJECTIVETo compare the effect on surgical indicators and functional outcome between preoperative skeletal traction and skin traction for adult femoral fracture and guide the choice of preoperative traction method of adult femoral fractures.

METHODSFrom February 2008 to September 2012, 68 patients aged greater than 18-year-old with femoral fractures were treated and randomly divided into two groups according hospitalization order,the odd with skeletal traction of tibial tubercle (group A) and the even with skin traction (group B). In group A, there were 25 males and 9 females with an average age of (36.3±9.9) years old,including 11 cases with transverse fracture, 15 cases with oblique fracture, 8 cases with spiral fracture. In group B, there 26 males and 8 females with an average age of (37.1±11.0) years old,including 10 cases with transverse fracture, 13 cases with oblique fracture,11 cases with spiral fracture. The operative time,blood loss,the number and amount of blood transfusion ,fracture healing time, hemoglobin, pain scores and functional scores between two groups were analyzed and compared. Results:All patients were followed up, the follow-up time was (33.5±6.5) months in group A, (31.3±7.5) months in groupB. In group A,the operation time was (108.8±14.2) min and the intraoperative blood loss was (383.1±117.1) ml and the postoperative blood transfusion was 14 cases and the blood transfusion was (350.0±122.5) ml and the average bone healing time was(15.0±3.3) weeks. In group B, the operation time was (111.6±12.7) min and the intraoperative blood loss was (392.0± 116.7) ml and the blood transfusion was 11 cases and the blood transfusion was(327.3±129.1) ml and the average healing time was (15.5±3.4) weeks. These obseration indicators had no significant difference between two groups. There was no significant difference between two groups in terms of Hemoglobin, the pain scores before and after traction, the femoral fractures efficacy score,knee function score and knee range.

CONCLUSIONPreoperative skeletal traction does not reduce surgery time, blood loss and pain and so on. The bone healing time and limb functional outcomes were also not significantly improved.

Adult ; Blood Loss, Surgical ; Bone and Bones ; surgery ; Dermatologic Surgical Procedures ; Female ; Femoral Fractures ; physiopathology ; surgery ; Fracture Fixation, Internal ; Fracture Healing ; Humans ; Male ; Middle Aged ; Preoperative Period ; Traction ; Young Adult

Objective: To investigate whether Shuxuening injection has a protective effect on myocardial injury in rats with cecal ligation and puncture(CLP)- induced sepsis. Methods: Thirty SD rats were randomly allocated to Sham group, CLP group and Shuxuening group (SXN group). In the Shuxuening group, Shuxuening injection was intraperitoneally injected at a dose of 1 mg(0.3 ml)/body weight 1 h before CLP challenge. The sham and CLP groups received an equal volume of saline injection (0.3 ml/kg) at the same time points. Six hours later, the blood samples were obtained from abdominal aorta to determine the contents of TnT, TNF-α, and IL-1β. Meanwhile, MDA contents and SOD activities in myocardial tissues were also tested and the pathologic changes of the myocardial tissue were observed by H-E staining. Results: Compared with CLP group, the serum contents of TnT, TNF-α, and IL-1β and myocardial tissue MDA were decreased in Shuxuening group; and the myocardial tissue SOD activities were significantly increased in Shuxuening group (P<0.05 or 0.01). Microscope observation showed that the degrees of myocardial congestion, edema, and inflammatory cell infiltration were greatly improved in the Shuxuening group compared with in the CLP group. Conclusion: Our results suggest that Shuxuening can protect against CLP-induced myocardial injury in rats, probably through scavenging free radical and inhibiting release of inflammatory mediators.

ObjectiveTo explore the surgical methods and its efficacy on severe chronic obstructive pneumonia disease (COPD) with spontaneous pneumothorax.MethodsClinical features and surgical efficacies of 16 cases of severe COPD were analyzed.Results No death occurred and all patients recovered and discharged.The lung function index including subjective symptoms,motor ability and endurance in 14 cases showed obvious improvement compared with those before combination of pneumothorax.Two patients improved to the level before surgery.ConclusionThe lung function index of patients with severe COPD and pnumothorax can be relatively less restricted and open-chest surgery should be performed as soon as possible.Linear nailing and simple lung volume reduction surgery are recommended to improve lung function,shorten operation time and reduce surgical risks.

BACKGROUND: Rheumatoid arthritis(RA) is an autoallergic disease,but its immunological pathogenesis has not been completely known. T lymphocytes, especially CD4+ TH1/TH2 cells, may have an important effect in the occurrence and development of RA.OBJECTIVE: To investigate the action of CD4+ TH1 and TH2 cells which separately mediate cellular immunity and humoral immunologic response (respectively) function in the occurrence and development of RA.DESIGN: Case-control, comparative observation.SETTING: Department of Immunology, Medical College of Chinese People's Armed Police Forces.PARTICIPANTS: Totally 15 patients with RA hospitalized in the Department of Internal Medicine of General Hospital of Tianjin Medical University between March 1999 and March 2000 were selected for a RA patient group, consisting of 2 males and 13 females. Of them, 12 patients whose serumal rheumatoid factor (RF)was positive and the three others' was negative. At the same time, 30 healthy individuals from persons receiving health examination in the hospital or from our department were selected for a healthy control group, consisting of 4 males and 26 females. Informed consents were obtained from the participants.peripheral blood mononuclear cells(PBMC) from the two groups of subjects were detected by enzyme-linked immunospot assay (ELISPOT). 200-500 lymphocytes were counted under a normal light microscope, and the perwhich secreted cytokines were detected by ELISPOT, and those which had red spots in their plasma after staining were positive cells. Among them,the cells secreting γ-interferon (IFN-γ) were Tm cells while those secreting interleukin-4 (IL-4) were TH2 cells. 200-500 lymphocytes were counted under a normal light microscope and the percentages of TH1 and TH2 cells square test were used for comparing statistical differences of data between the two groups.MAIN OUTCOME MEASURES: Quantitative analysis of T lymphocyte subsets (including CD3+ T cells, CD4+ T cells and CD8+ T cells) and CD4+ TH1/TH2 cells in peripheral blood from the two groups of subjects.RESULTS: Analysis of the results was from the study on all of subjects percentages of total T cells (CD3+ T cells), CD4+T cells and CD8+F cells in peripheral blood were not significantly different between the two significantly higher in RA patient group than that in healthy control group [(24.44±5.25)%, (14.93±3.82)%, P ＜ 0.05],while in RA patient group the percentage of TH2 cells and ratio of TH1 cells to TH2 cells from peripheral blood were not significantly different as compared with those of control group(P ＞ 0.05).CONCLUSION: Cellular immunologic function mediated by TH1 cells may be associated with the occurrence and development of RA.

Objective To study the effect of astragalus complanatus on the metabolism of free radicals in liver and exercise performance in models of exhaustive training rats.Methods After 7 d adaptive training,we randomly divided rats into three groups: quiet control group(A),sport training group(B) and astragalus complanatus training group(C).We measured rat liver indices such as the activities of total superoxide dismutase(T-SOD),glutathione peroxidase(GSH-Px),catalase(CAT) and content of malonaldehyde(MDA).Results The activity of astragalus complanatus groups(C) T-SOD(78.17?0.17),GSH-Px(35.42?1.68) and CAT(17.61?0.05) in liver tissue increased and the content of MDA(6.70?0.53) decreased remarkably compared with that in sport training group(B).Conclusion As an efficient free radical scavenger,astragalus complanatus can strongly enhance anti-oxidative status and improve exercise performance in trained rats.

Objective To investigate the relationship between occurrence of unexplained recurrent spontaneous abortion(URSA) and immune function of T lymphocytes. Methods T lymphocyte subsets and CD + 4 T helper subsets (including T helper 1 and T helper 2 cells) in peripheral blood from 30 cases with URSA and 24 healthy women (controls) were detected by enzyme-linked immunospot assay (ELISPOT). Results The percentage of CD + 4 positive T lymphocytes in URSA group was higher than that in the controls (60% vs 45%, P

AIM:To investigate the differences of clinical signs and pathological structure of unilateral nasal pterygium and unilateral double pterygium.METHODS:Retrospective study.Totally 11 unilateral nasal pterygium and 11 unilateral double pterygium were collected to observe the size of the tissue area, the classification of blood vessels, the transparency and the break-up time of tear film.The 11 surgically excised double pterygia (11 eyes) and 6 samples of normal conjunctiva were collected for the study.With 40g/L paraformaldehyde fixation, paraffin sections were stained with Haematoxylin-Eosin, to observe the differences with nasal and temporal pathology under light microscope.RESULTS:In unilateral double pterygium, the tear break-up time was significantly shorter than that of unilateral nasal pterygium (t=3.410, P=0.003).In unilateral nasal pterygium, there was a significant negative correlation between tear film break-up time and tissue size(r=-0.927, P<0.01) and transparency(r=-0.764,P<0.01).In unilateral double pterygium, the tear break-up time was significantly negatively correlated with the growth time (r=-0.661, P<0.05), tissue size (r=-0.775, P<0.01) and transparency (r=-0.671,P<0.05).In unilateral double pterygium, compared with the temporal side, the quantity of the layers of corneal epithelial cells (t=-7.351, P<0.05), vessels (t=-7.400, P<0.05) and inflammatory cells (t=-7.481, P<0.05) increased.CONCLUSION:Compared with unilateral nasal pterygium, the tear film break-up time of unilateral double pterygium was poor.In unilateral double pterygium, with high activity, the degree of proliferation of squamous epithelium, hyperplasia and inflammatory reaction are significantly higher than those of the temporal side.

Objective To analyse the cause of misdiagnosis of tuberculosis peritonitis and discuss feasibility for diagnosis of tuberculosis peritonitis by laparoscopy. Methods 12 patients misdiagnosed as tuberculosis peritonitis were retrospectively analysed. Results Tuberculosis peritonitis wrongly diagnosed because of atypical clinical behaviors in spite of specific laboratory examination. However, laparoscopy could diagnose tuberculosis peritonitis exactly and quickly. Conclusion Laparoscopy is an effective method of diagnosis for tuberculosis peritonitis.