1.The clinical applications of the PET/CT in lung diseases
Chinese Journal of Practical Internal Medicine 2001;0(04):-
At present,lung diseases,particularly lung cancer,remain the major diseases that threaten human health,and the diagnosis,staging and re-staging and therapy evaluation of lung diseases are still the hot and difficult problems.PET(positron emission tomography)imaging can display the organic functions,metabolism,and other information at molecular level.PET has unique advantages and clinical application value in the diagnosis of lung diseases.This paper reviews the related literatures and presents typical cases for the discussion of PET/CT in lung diseases.
2.The Characteristics and Influencing Factors of Doctor-patient Trust in Township Hospitals under the New Health Care Reform
Chinese Medical Ethics 2014;(2):173-176
This paper analyzed some policies of new health care reform from the perspective of doctor -patient trust.The implementation of the policy of income and expenses in two lines has changed the management mode of township hospitals , eliminated some factors harming the doctor -patient relationship .The policy of equalization of public healthand other policies have guided the hospitals to change the way of service , service and health man-agement into the village increased the degree of doctor -patient trust .But at the same time , to ensure the new health care reform run smoothly , township hospitals introduced various ways of prescribing restraints .In addition , the policy of zero profit for basic drugs also brought some restrictions and regulations , resulting in a decline of satis-faction of patients , who have a tendency to blame the hospitals and doctors for these inconveniences .This misun-derstanding has becomed the new difficulties for doctor -patient trust as policy running .
3.Effects of Huanyuan Injection on Physiological Paramenters and Spontaneous Firing of Hippocampal CA1 Neurons in Experimental Intracerebral Hemorrhage Rats
Chinese Traditional Patent Medicine 1992;0(02):-
0.05). After experimental cerebral hemorrhage for 4 hours of model group, blood pressure and P O 2 were obvious increased( P 0.05), but they were lower than model group at the meantime ( P
4.Studies of assessment of myocardial viability by Tc - ~(99m) sestamibi myocardial scintigraphy and application coronary revasculatrization
Ming ZHANG ; Yaming LI ; Zhanquan LI
Chinese Journal of Practical Internal Medicine 2001;0(05):-
Objective The purpose of the studies was to explore the elective ways to enhance the ability of routine rest To - 99m - sestamibi (MIBI) myocardial scintigraphy to assess myocardial viability during the percutaneous transluminal coronary angioplasty (PTCA ) in assessing viable myocwhium. Methods Three methods, (1) rest- nitroglycerine augment, (2) rest-gated, (3) rest-delayed 99mc - MIBI myocardial scintigraphies, were performed in 20,30 and 10 patients with coronary artery disease treated with coronary revascularization. Results The results showed that in evaluating viable myocardium, the positive predictive values for methods(1 )-(3) were 95. 9%,68. 5% and 84.1%,mepectively, the negative predictive values were 68. 2%, 90. 1% and 90.0%, respecihvely, the predictive accuracy rates were 82. 5%, 77. 3% and 87.2%. Conclusions The results indicate that identification of viable myocardium with 98mTc - MIBI can be effectively enhanced with methods (1) - (3); the 99mTc - MIBI myocardial scintigraphy can provide objective data for evaluating treatment effects by coronary revascularization.
5.Effects on weights and lipid of obese rats by combination of puerarin and glucose tolerance factor(GTF) at molecular level
Yaming LIU ; Jin LI ; Daohui DU
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(08):-
Objective:TCM Gegen extract(puerarin)and glucose tolerance factor(GTF) can regulate glucose metabolism and lipid metabolism.The purpose of research is to observe effect of the comoles compound of puerarin and GTF at molecular level on diet-induced obesity in rats.Methods:Male SD obese rats,induced by high fat feed,were randomly divided into fi ve groups:obese model group,positive medicine control group,the groups with small,middle and large of puerarin and GTF,and normal control group.The rats were given medicine for four weeks,body weight of every week,and lipid were measured.Results:After being fed the comoles compound of puerarin and GTF at molecular level for four weeks,the weight growth of rats was slowed down,the level of the following quota:TG,TC,serum insulin and serum leptin declined,the level of HDL-C increased.Compared with obese model group,there was a difference(P
7.Progress on the clinical research of fluoro-3(2(S)-2-azetidinylmethoxy) pyridine and Iodo-3-(2(S)-azetidinylmethoxy) pyridine
Yuyan JIANG ; Yafu YIN ; Yaming LI
Chinese Journal of Nuclear Medicine and Molecular Imaging 2015;35(4):322-325
Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a spectrum of cognitive functions and related to some psychiatric and neurodegenerative disorders such as AD,PD,autosomal dominant nocturnal frontal lobe epilepsy and schizophrenia.Nuclear medicine imaging of neuronal nAChRs in living human is a relatively new field.Halogenated analogs of 3 (2 (S)-2-azetidinylmethoxy) pyridine (A-85380) are the most widely used brain imaging radiotracers.In this review,the progress on the latest research on SPECT and PET using the analogs of A-85380 is summarized.
8.Evaluation of the effect of 90Sr-90Y applicator treatment for hemangioma by superficial ultrasound
Jianwei FENG ; Qinyi GAO ; Yaming LI
Chinese Journal of Nuclear Medicine and Molecular Imaging 2015;35(1):41-43
Objective To evaluate the efficacy of 90Sr-90Y applicator treatment for hemangioma by superficial ultrasound.Methods A total of 94 infants with hemangioma were retrospectively analyzed,including 37 males and 57 females (age range:1-12 months,mean =4.5 months).Thickness of hemangioma was measured by superficial ultrasound on the day before 90Sr-90Y applicator treatment,10 d and 3 months after treatment.Paired t test and x2 test were used to analyze data.ROC curve was analyzed to determine the tumor thickness which could be cured by one-cycle of treatment.Results Sixty-two cases were cured,29 cases had partial response and 3 cases had treatment failure.Thickness of hemangioma was (0.38 ±0.28)cm before treatment and (0.16±0.35) cm 3 months post-treatment and the difference was statistically significant (t=7.377,P<0.05).The treatment effect of 90Sr-90Y applicator was not influenced by gender.According to the site of hemangioma,the curative rates were 20/38 in head & neck,22/33 in chest,20/23 in limbs.Only the difference between the curative rates in head & neck and limbs was statistically significant (x2 =7.478,P<0.05).The treatment effect of 90Sr-90Y applicator was evaluated by the thickness of hemangioma under the skin at 3 months post-treatment and the area under the ROC was 0.93.The threshold of the thickness of hemangioma which could be cured by one-cycle of treatment was 0.32 cm with the sensitivity of 93.8% and specificity of 85.5%.Conclusions The 90Sr-90Y applicator had a good treatment effect on pure hemangioma in infants,especially for those located in limbs and torso.The lesion with thickness less than 0.32 cm had a higher chance to be cured by one-cycle of treatment.
9.Recent advances in PET radioligands for imaging of cerebral nicotinic acetylcholine receptors
Yexiong MO ; Yafu YIN ; Yaming LI
Chinese Journal of Nuclear Medicine and Molecular Imaging 2013;33(6):510-514
There exist many studies on the radioligands for imaging of nicotinic acetylcholine receptors (nAChRs) in the human brain and the most common one is the radioligand binding to α4β2-nAChRs,the main subtype of cerebral nAChRs.There are few data published in the literature on the radioligands for the imaging of α7-nAChRs,another important subtype of cerebral nAChRs.This review summarizes recent work on PET radioligands for the imaging of cerebral nAChRs.
10.Study on the diagnosis and mechanism of hemispatial neglect using different imaging modalities
Lele HUANG ; Yafu YIN ; Yaming LI
Chinese Journal of Nuclear Medicine and Molecular Imaging 2013;33(4):315-318
Hemispatial neglect is a kind of cognitive impairment characterized by failure to report,respond or orient to stimuli presented in ipsi-or contra-lateral space after brain injury,which cannot be attributed to sensory or motor defects.Although there are various diagnosis and assessment methods,none is regarded as standard.The paper and pencil test is commonly used in routine clinical workup.The mechanism is controversial and the most accepted opinion is due to visuospatial attention defect.Imaging study focuses on exploring the functional regions leading to the hemispatial neglect.As functional imaging,SPECT and PET have capability to evaluate the perfusion,glucose metabolism and cellular vitality,which have been found increasingly useful and applicable clinically in the field of diagnosis for cognitive impairment diseases.They are likely to have potential for contribution in the study of hemispatial neglect.