Objective To observe the effect of local pain alleviation by wet compress with room temperature and low temperature lidocaine and cold wet compress in fructose infusion in children. Meth-ods 120 children patients with pain during fructose infusion were randomly divided into the wet compress group, the room temperature lidocaine group and the low temperature lidocaine group with 40 cases in each group. The analgesic effect was observed in the three groups. Results Analgesic effect of the low temper-ature lidocaine group was significantly better than the other two groups. Conclusions The wet compress with low temperature lidocaine can relieve the local pain in fructose infusion in children.

BACKGROUND:Mini-screw stability is primarily related to alveolar bone cortical thickness. It is necessary to learn cortical thickness to choose suitable implanting sites and predict success rate. OBJECTIVE:To evaluate the buccal cortical thickness in maxilary posterior area of Class II Division I malocclusion adolescents. METHODS: Fifty-two adolescents (including 26 male and 26 female) of Class II Division I malocclusion scanned by Cone Beam Computer Tomography were involved in this study. The buccal cortical thickness of six posterior interradicular sites (14-15, 15-16, 16-17, 24-25, 25-26, 26-27) at four bone levels (2, 4, 6, 8 mm) from the alveolar crest in both boys and girls were measured. RESULTS AND CONCLUSION: (1) There was no statisticaly significant difference in alveolar cortical thickness between left and right sides in the girls (P > 0.05); cortical thickness of 5-6 and 6-7 at 8 mm was thicker than that at 2 mm (P < 0.05) and cortical thickness of 6-7 at 2 mm was smaler than that at 8 mm (P < 0.05). The cortical thickness increased from crest to base of alveolar crest and reached the peak at 8 mm. Cortical thickness of 6-7 was thicker than 4-5 at 8 mm depth (P < 0.05). The results of males were the same as females. (2) There was no statisticaly significant difference in alveolar cortical thickness of the same site between males and females (P > 0.05). Al sites in this study were suitable for mini-screw implantation; from the first molar to posterior dental arch, buccal cortical thickness is wel-distributed; it is dangerous for implantation in the areas around the first molar more than 6 mm, where the frequent presence of the maxilary sinus is observed. There is an increase of buccal cortical thickness from crest to base of alveolar crest, obtaining good initial stability.

Objective:To determine the prevalence of dyslipidemia in students from the primary and middle schools and the influential factors,and to provide evidence for the prevention and control of dyslipidemia and relevant chronic diseases in primary and middle schools.Methods:A total of 2 028 students aged 7 to 17 from the primary and middle schools in Changsha were selected by stratified random cluster sampling.The contents of the study included questionnaire survey,physical measurement and blood tests for fasting blood triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),and high-density lipoprotein cholesterol (HDL-C) levels.Non-high-density lipoprotein cholesterol (non-HDL-C) level was calculated by TC level minus HDL-C level.Chi-square test and non-conditional logistic regression model were used to analyze the factors that contributed to dyslipidemia.Results:The dyslipidemia rate was 18.6％,and the abnormal rates of TG,TC,LDL-C,non-HDL-C and HDL-C were 6.8％,5.6％,2.3％,4.2％ and 8.6％,respectively.By chi-square test,the dyslipidemia rate in students with different ages,home locations,BMI groups,central obesity,time on watching TV or playing computer per day,and daily sleep time was statistically significant.Non-conditional logistic regression analysis showed that home location for the city (OR=1.332),overweight (OR=1.548),obesity (OR=2.201),central obesity (OR=1.695),watching TV or playing computer for more than 2 hours per day (OR=1.357),daily sleep time longer than 11 hours (OR=2.518) were the risk factors for dyslipidemia in students from the primary and middle schools.Conclusion:Nearly 1/5 primary and middle school students show dyslipidemia,which is associated with obesity and other bad behaviors.

Objective To investigate the role of interleukin-22 (IL-22)-regulated autophagy in hydrogen peroxide (H2 O2 )-induced hepatocarcinoma cell damage. Methods HepG2 cells were transfected with pEGFP-LC3 and then cultured in RPMI 1640 medium free of fetal bovine serum (FBS) or containing 1％ or 10％ FBS. These cells were pretreated with rapamycin or an autophagy inhibitor (3-MA) and then stimulated with recombinat human IL-22 (rhIL-22). GFP-LC3 puncta formation and autophagy signaling ac-tivation were measured. MTT assay was performed to detect cell viability. Results rhIL-22 significantly promoted GFP-LC3 puncta formation and LC3-Ⅱ expression in HepG2 cells treated with different stimulation protocols. The autophagy pathway inhibitor, 3-MA, dramatically suppressed the rhIL-22-activated autophagy signals. rhIL-22 attenuated H2 O2-mediated HepG2 cell death and that could be inhibited by 3-MA. Conclu-sion IL-22 promoted the activation of autophagy signaling pathways and alleviated H2 O2-mediated HepG2 cell damage.

OBJECTIVE： To investigate the characteristics and regularity of gestational （including perinatal period） adverse drug reactions （ADR） in Sichuan province， and to provide evidence for ensuring the safety and effectiveness of drug use in clinic. METHODS： Gestational ADR reported to Sichuan provincial ADR monitoring center from Nov. 2016 to Nov. 2017 were statistically analyzed in respects of report source， personnel distribution， general information of patients， route of administration， drug types and main drugs， involved system/organ， grading and outcome， etc. RESULTS： A total of 1 309 gestational ADR cases   （1 340 case time） were collected， in which 1 305 were from medical institutions， 3 from enterprises and 1 from manufacturer. There were 986 physicians， 188 nurses， 133 pharmacists and 2 commissioners for drug safety. 859 cases （65.62％） were 21-30 years old， accounting for the largest proportion. 867 case time were caused by intravenous administration （64.70％）. ADR-inducing drug types mainly included reproductive system drugs （491 case time， 36.64％）， antimicrobial drugs （479 case time， 35.75％） and blood system drugs （110 case time， 8.21％）. Main of them were Carboprost tromethamine injection （187 case time， 13.96％）， Cefazolin sodium for injection （122 case time， 9.10％） and Oxytocin injection （105 case time， 7.84％）. ADR mainly involved skin and its appendants （517 case time， 33.95％）， gastrointestinal system （387 case time， 25.41％）， whole body （175 case time， 11.49％）.  In 1 309 gestational ADR， 1 251 cases （95.57％） were general ADR； 58 cases （4.43％） were severe ADR， including 14 life-threatening cases， 7 extended hospital stay and 37 others； 592 （45.22％） patients improved， 716 （54.70％） recovered and 1 （0.08％） did not improve. CONCLUSIONS： In clinical practice， it is necessary to strengthen the monitoring of drug use in patients during gestational， especially monitor ADR of uterine contraction drugs and antimicrobial drugs during gestational， use drug cautiously and promote clinical medication safety in gestational patients.