Complications may occur inevitably during percutaneous coronary intervention(PCI),and sometimes can be life-threatening.These complications occur in approximately 5.53% of patients at large PCI centers in China.Severe complications include coronary artery perforation,acute coronary closure,no flow and acute thrombosis.Efforts should be exerted to prevent and avoid these complications during perioperative period of PCI.

Objective To investigate the change of permeability of HUVECs monolayer induced by thrombin or Lipopolysaccharide(LPS) for exploring the role of RhoA.Methods The effect of thrombin or LPS on the permeability of HUVECs monolayer was examined with the polycarbonate transwell filters and the effect of thrombin or LPS on HUVECs F-actin was observed with immunocytochemistry.The interferring action of Y-27632(Rho kinase inhibitor) on the permeability and F-actin change induced by thrombin or LPS was also observed.The expression of RhoA protein and mRNA in HUVECs were detected by Western blotting and semi-quantitative RT-PCR.Results Thrombin or LPS induced F-actin depolymerized and significant increase in the permeability of HUVECs.Permeability and F-actin do not change significantly when Y-27632 was added.Thrombin or LPS could upregulate the expression of RhoA protein and mRNA in HUVECs.Conclusion HUVECs monolayer permeability injury induced by thrombin or LPS is related to depolymerization of F-actin and RhoA signal pathway is involved.

The well performance of everything in the peripheral operative period is important to improve successful rate, decrease complications and assure favorable convalescence of patients for interventional treatment of coronary heart disease. It is mentioned that the primary management of peripheral operative period and main notes for interventional treatment of coronary heart disease in the paper summarily.

80 years)in China is increasing.As a special type of hypertension,the hypertension in the very elderly has some specificities in pathogenesis,clinical manifestation,treatment and prognosis.The topic to effectively cure and prevent hypertension in the very elderly is increasingly emphasiced.This article presents an overview of recent progress in clinical characteristics,and treatment strategy related to hypertension in the very elderly.

Objective An intensive analysis on the recent advances in cardiovascular medicine both in China and abroad was made,so as to provide an orientation of developing cardiovascular medicine in the future.Methods Literature of cardiovascular medicine published domestically and abroad in recent 5 years was reviewed.The advances in the use of new drug and techniques,clinical diagnosis and therapeutic methods were analyzed.Results Cardiovascular medicine in basic,clinical and practical fields had made rapid advances in the military institutions lately,especially in the interventional diagnosis and treatment of coronary heart disease,arrhythmia and peripheral vascular disease,and in the treatment of hypertension,where outstanding successes had been achieved.Conclusions The general level of cardiovascular medicine of military medical establishments could be considered foremost in our country.During the coming years of "the 12th Five-Year Plan",the emphasis of research work should be placed upon the medical care,basic and clinical research of common cardiovascular diseases existing in military officers and soldiers,such as coronary heart disease,peripheral vascular disease and arrhythmias,both in peace time and military conflicts.

Contrast induced nephropathy is an important complication arising from use of iodinated contrast media.Such iatrogenic complication may result in poor prognosis and additional health care costs.Cases of contrast induced nephropathy are on the rise along with the-increasing number of contrast-requiring procedures.Contrast induced nephropathy has been a subject of concern to cardiologists in recent years.Several large series have shown no approved methods for management of periprocedural contrast induced nephropathy.However,identification of high-risk patients,improvement and rectification of related risk factors,use of iodinated contrast media with less renal toxicity,and sufficient hydration may reduce the incidence of contrast induced nephropathy.

The efficacy of the standard first-line chemotherapy regimen for advanced non-small cell lung cancer (NSCLC) has reached a plateau.Study confirmed that chemotherapy drugs and molecular targeted drug maintenance treatment can prolong the survival of patients with advanced NSCLC.Immunotherapy has become a maintenance treatment for advanced NSCLC,and further research is needed to confirm its efficacy.

Objective To explore clinical feature and coronary artery lesion characteristics of non-ST-segment elevation myocardial infarction (NSTEMI).Methods Seventy-three patients of NSTEMI were studied,their clinical data and results of coronary angiography being analyzed.Results Risk factors of coronary artery disease among all the patients were 50(68%) with hypertension,26(35%) with diabetes,34(46%) with hyperlipidemia and 28(38%) with smoking history.There were 52(71%)with angina pectoris before this hospitalization,22(30.6%) with inhospatial angina pectoris,15(20.4%) with severe arrythmias,7(10.2%) with cardiac shock,3(4%) died.52(71%) were with ST-T depression and 21(29%) with normal ECG.Coronary angiography revealed 54(74%) with lesions in more than one vessel and 19(26%) in one vessel (P

Objective To explore the post-implant complications of permanent cardiac pacemakers,their reason,treatment and preventive measures.Methods The records of 516 patients receiving a permanent pacemaker were reviewed and complications of the patients were analyzed.Results There were 69 cases of complications after the permanent cardiac pacemaker implantation,5 cases(7.2%) of infection,10 cases(14.5%) of haematoma,7 cases(10.1%) of pocket rankle,10 cases(14.5%) of hemothorax and pneumothorax,10cases(14.5%) of pacemaker syndrome,7 cases(10.1%) of undersensing,2 cases(2.9%) of pacemaker mediated tachycardia,3 cases(4.4%) of battery exhaust advance,3 cases(4.4%) of arrhythmia,10cases(14.5%)of electrode displacement and 2 cases (2.9%) of electrode fracture.Conclusion Good prognosis will be resulted from deep understanding of the usual complications,increased differentiating ability, emphasized pre-operation prevention,standardized operation,strengthened follow-up as well as the education of pacemaker knowledge,early discovery and treatment of the complications.

60 years old with coronary artery disease in hospital from Jan.2002 to Aug 2004 who accepted coronary intervention.They were divided into Tansradial group(TRA,n=382) and Transfemoral group(TRF,n=382).The success rate and time of puncture,x-ray exposure time,procedure duration,dose of dye,complication in puncture site and pulmonary embolism were observed in the two groups.Results 368 out of 382 cases success in TRA group and 372 cases in TRF group.The success rate was not different.The success rate of puncture,x-ray exposure time,procedure duration and dose of dye had no difference between the two groups.But the complication in puncture site and pulmonary embolism were more in TRF group than in TRA group.The coronary intravascular ultrasound and cutting balloon technique were successfully done in two groups.The mean in-hospital time was less in TRA group (2.1?0.6 days) than in TRF group (4.2?1.6days,P