Objective To compare the effect of vaginal and laparoscopic myomectomy.Methods According to the digital table,98 patients with uterine fibroids were randomly divided into the two groups,the control group(n =4 9 eases) and the observation group (n =4 9 cases).The patients in the control group were operated through laparoscopic myomectomy,while the patients in the observation group were operated through vaginal myomectomy.The operative time,blood loss,postoperative gastric function recovery time,exhaust time,complications,recurrence and quality of life,etc.were observed.Results The operative time,blood volume were (115.4 ± 29.4) min,(191.4 ± 30.2) mL in the control group and (70.1 ± 18.2) min,(156.1 ±21.6)mL in the observation group.The operative time,blood volume in the control group were more than those in the observation group,there were significant differences between the two groups (t =3.169 4,2.162 8,P ＜ 0.05).Gastric function recovery and exhaust time were (2.8 ± 0.7) h,(23.1 ±4.1)h in the control group and (1.3 ±0.5)h,(15.1 ±3.5)h in the observation group.Gastric function recovery and exhaust time in the control group were higher than those in the observation group (t =2.091 4,3.771 8,all P ＜ 0.05).The number of cases of complications and recurrence were 1,2 in the control group and 2,1 in the observation group.There was no significant difference between the two groups about the number of cases of complications and recurrence (x2 =2.02,0.00,all P ＞ 0.05).Quality of life after operation was (7.26 ± 2.01) in the control group,and (8.42 ± 2.17) in the observation group.The quality of life in the observation group improved more significantly than the control group (t =0.361 8,3.901 6,all P ＜ 0.05).Conclusion Vaginal myomectomy had less trauma,quicker recovery,and help to improve the quality of life.

ObjectiveTo find the mechanism of Heshouwuyin(HSWY) in anti-aging, so as to provide theoretical and experiment evidence for the application of HSWY. Methods50 eight-week female SD rats ( SPF degree)were used in this study. The rats were randomly divided into 5 groups:normal control group, 10 rats; model group,10 rats; HSWY anti-aging group, including low, middle and high dose group,10 rats in each group. The sub-acutely aging rats were made by ip injection of D-galactose for 60 days continually. The rats in HSWY groups were administered with various doses of intragastric HSWYduring D-galactose injection. The parameters of ovary levels of SOD,GSH-PX, TAOC were detected. ResultsThe MDA in ovaries of model rats was significantly higher than that of negative control group;while the SOD, GSH-PX, TAOC of model rats were significantly lower than negative control group.The MDA content in ovaries after taking HSWY was significantly lower than that of model rats; while the SOD, GSHPX,TAOC of the taking HSWY rats was significantly higher than that of model rats. ConclusionThe HSWY could increase antioxida tive activity of rat ovaries to stay D-galactose induced consenescence.

Objective To investigate the clinical associated risk factors which affect the postpartum urinary incontinence ,providing theoretical basis for early prevention and treatment of this disease . Methods The clinical data of 60 cases who diagnosed postpartum urinary incontinence were collected ,and established database ,and apply regression analysis method were used to analyze the clinical associated risk factors .Results The results showed that BMI(OR=2.534,95%CI:0.975 ~6.489 ),fetal weight (OR =2.342,95%CI:0.723 ~6.575) second stage (OR=3.346,95%CI:0.635~6.673).Conclusion high BMI,fetal weight is heavy,prolonged second stage was re-lated risk factors with postpartum urinary incontinence .

The results of the arterial blood study in 30 patients of cor pulmonale in acute exacerbation were reported.The study included gas analysis, and dominations of serum lactate,pyruvate, potassium,sodium and chlorine.All the items were determined simultaneously.The data demonstrated that when the arterial oxygen tension of the patients with cor pulmonale in acute exacerbation dropped below 60mmHg, the blood lactate concentration was most likely to show a rise, which was related not only to hypoxemia but also to alkalosis.Observations of the changes in concentration of blood lactate and pyruvate in some patients led us to believe that these changes were associated with the seriousness of the disease. Regular measurement of blood lactate and pyruvate concentrations might be helpful to judge the condition of the patient. Persistent rise in blood lactate concentraion suggested poor prognosis.

Objective To explore the status quo of knowledge,belief,and practice of anticoagulationrelated self-management in rehabilitation period for patients with haeat valves replacement.Methods Van Manen's hermeneutic phenomenology was used as qualitative research method.Twenty patients who had undergone heart valves replacement operation were selected and interviewed.The results of interview were analyzed with category analysis.Results After repeated self-examination,comparison,and summery,four themes were refined,including patients lack anticoagulation-related knowledge and skills in rehabilitation period,the levels of patients' attitudes and beliefs varied greatly,patients' compliance of self-management behavior and taking medicine was low,there were limited channels to get anticoagulation-related information in rehabilitation period.Conclusions More attention should be paid to patients for anticoagulation management after valve replacement operation,especially to those of low literacy,older age,and rural area.Nurses should implement the specific health education about anticoagulation management to patients during discharge guide and following-up period to minimize complications,promote the survival rate,and improve their quality of life.

Based on the peak value of power spectral density (PPSD) and corresponding frequency (CF), an approach that performs electroencephalogram (EEG) feature extraction during imaginary right and left hand movements was proposed. The data were gained from brain computer interface competition in 2003 provided by Graz University of Technology. The EEG signals between 8-16 Hz were decomposed by db3 wavelet packet at three levels. The PPSD and CF of electrodes C3 and C4 were defined as the EEG feature vectors and calculated respectively. The left and right hand motor imaginary tasks were distinguished by the time-variable linear classifier. The proposed method was applied to the test data for 140 trials. The satisfactory results were obtained with the highest classification accuracy 89.29%. The maximum mutual information was 0.622 8 bit, and the signal-to-noise ratio (SNR) was 1.371 3. The PPSD and its CF on electrodes C3 and C4 between 8 and 16 Hz were coincident with event-related desynchronization (ERD) and event-related synchronization (ERS). This method is simple, quick, and promising for on-line brain computer interface system.

Objective To evaluate the effects of fasudil on neointima hyperplasia in rat carotid artery balloon-injury model,and explore the potential molecular mechanisms of this effect.Methods Totally 30 male Sprague-Dawley (SD) rats were randomly divided into sham operation group,balloon injury group,2.5 ml/kg fasudil intervention group,5 ml/kg fasudil intervention group,10 ml/kg fasudil intervention group.The intima-to media(I/M) area ratio of neointima was calculated at 14th day after operation; the protein expression of proliferating cell nuclear antigen(PCNA) was measured by immunohistochemical and the integrated optical density (IA) was calculated.As the marker of oxidative stress,the levels of 8-hydroxy-2'-dcoxyguanosine (8OHdG) and malondialdehyde (MDA) were measured by enzyme-linked immunosorbent assay (ELISA).The expressions of phosphorylated and non phosphorylated Ras,mitogen activated protein kinase kinase (MEK1/2) and extracellular signal regulated kinase (ERK1/2) were measured by Western blot.Results The I/M ratios were (0.22 ± 0.01) in sham operation group,(2.71 ± 0.23) in balloon injury group,( 1.72 ±0.24)in 2.5 ml/kg fasudil intervention group,(1.23±0.11)in 5 ml/kg fasudil intervention group,(0.85±0.12)in 10 ml/kg fasudil intervention group.As compared with sham operation group,I/M area ratio was increased in balloon injury group,and three fasudil intervention group inhibited neointima hyperplasia in a dose-dependent manner (all P＜0.01).The IA indexes were(15.11 ±1.42),(53.42±2.30),(45.25±1.62),(22.55±0.88) and(19.61±0.79) in the above five groups,respectively,showing the fasudil inhibited PCNA expression (all P＜0.01).Fasudil also inhibited the levels of 8-OHdG and MDA in a dose-dependent manner [8OHdG:(54.34±4.50)μg/kg,(106.81 ± 6.67)μg/kg,(94.21 ± 3.34) μg/kg,(65.58 ± 5.13) μg/kg,(51.32 ± 2.34) μg/kg; MDA:(19.94 ± 0.65 ) μmol/kg,( 58.83 ± 2.81 ) μmol/kg,(48.94 ± 1.35 ) μmol/kg,(40.62 ± 3.24 )μmol/kg,( 36.85 ± 0.91)μmol/kg (all P＜0.01)].Compared with balloon injury group,the relative expressions of Ras in three fasudil intervention group were 0.49±0.12,0.39±0.13,0.20±0.23 vs.0.62±0.10(P＜0.05 or,P＜0.01); MEK1/2 0.35±0.14,0.29±0.09,0.11±0.12 vs.0.56±0.1(P＜0.05 or,P＜0.01); ERK1/2 0.48±0.15,0.32±0.08,0.12±0.09 vs.0.64±0.13(P＜0.05 or,P＜0.01).The activations of ERK1/2,MEK1/2 and Ras were strongly suppressed in fasudil treated samples on day 14 after balloon injury.Conclusions Blockade of oxidative stress and Ras MEK1/2 ERK1/2 pathway is involved in the fasudil attenuating of balloon injury-induced neointima hyperplasia

Objective To observe the effect of comfort care on psychological status and life quality of patients undergoing interventional treatment of coronary heart disease. Methods 86 cases patients with coronary heart disease were randomly classified into the observation group and the control group with 43 cases in each group. The observation group was treated with comfort care and the control group was treated with normal nursing. The psychological status and life quality between the two groups were compared. Results Compared with pre-nursing, not only physiological function, independence, spiritual beliefs, social relations and quality of life but also SAS and SDS in the observation group were significantly improved after nursing. However, there were no significant differences in the control group. Moreover, the scores of life quality and anxiety and depression were significantly better than those in the control group. Conclusions Comfort care on patients with coronary heart disease can improve anxiety and depression status, servicing satisfaction and life quality of patients.

Objective To observe the effect of nursing intervention on anxiety and depression status and life quality of patients with chronic heart failure (CHF). Methods 124 cases patients with CHF were randomly classified into the observation group and the control group with 62 cases in each group.The observation group was treated with nursing intervention,the control group was treated with routine nursing.The anxiety and depression status and life quality between the two groups were compared. Results Compared with pre-nursing,not only SAS and SDS score but also physical function,role function,emotional function,social function and quality of life in the observation group were significantly improved after nursing.However,there were no significant differences in the control group.Moreover,the scores of anxiety and depression and life quality were significantly better than those in the control group. Conclusions Nursing intervention for patients with CHF can improve anxiety and depression status and life quality of patients.

Diabetic ketoacidosis is one of the most common causes of death in the pediatric diabetes,and it is also one of the most common endocrine emergencies in children.With the further studies of this disease,more attentions are paid to the central nervous damage about DKA.The mechanisms about DKA-related cognitive dysfunction from the macro to the micro are constantly updated.This article gives a review on the pathogenesis of the cognitive dysfunction due to DKA.