Objective:To investigate the efficacy of low-dose thyroid hormone treatment and the change in levels of thyroid hormone in patients with chronic kidney disease. Methods: 92 children with chronic kidney disease were randomly divided into thyroxine treatment group and control group, with 46 children in each group. All patients received conventional treatment, the treatment group served with additional Levothyroxine of 25 ~ 50?g/d. At least 1 month follow-up was taken to compare the clinical efficacy, RIA detection level of thyroxine. Results: In control group ,urinary protein, urine occult blood, Hb and albumin showed no changes at 1w-4w after therapy, and the treatment group also showed this trend. There were no difference between two groups. However, 1 week after treatment, SCr and BUN began to decline, till 4th week(P

Objective To investigate the relationship of the occurrence of sinusitis with nasal septum devia-tion.Methods 102 patients with nasal septum deviation confirmed by spiral CT and sinus endoscopy were included. The coronal CT images of all cases were observed.The incidence of sinusitis in different type of nasal septum deviation was calculated and the correlation between sinusitis with nasal septum deviation was analyzed.Results Among 102 patients with nasal septum deviation,deviated septum at high position in 71 cases,deviated septum beyond high position in 31 cases.Sinusitis was detected in 67 cases,accounted for 65.6%,of which unilateral involving in 38 cases,bilateral involving in 29 cases.Main lesions in the nasal septum deviation concave side in 46 cases (68.7%),in nasal septum convex side in 12 cases (17.9%).Conclusion Deviated septum is an important factor in onset.Upper septum deviation and deviated concave side more likely arise sinusitis.

Objective To analyze the use of narcotic drugs and the first class of psychotropic drugs in inpatient pharmacy of Wuhan Red Cross Hospital from 2011 to 2015.Methods Using the defined daily dose (DDD) which recommended by WHO as an index, and the dispensatory and clinical routine dose recommended by Chinese Pharmacopoeia and New Materia Medica as references.Adopting DUI as the statistic index, the drug's variety, quantity, sums and use frequency of the narcotic drugs and the first psychotropic drugs in inpatient pharmacy of our hospital from 2011 to 2015 were analyzed.Results According to the results, there was an increasing trend in sales amount from 2011 to 2015,among them,4 kinds of injections, 2 kinds of oral tablets,1 kind of transdermal patch and 1 kind of the sustained-release tablets.The sales amount of narcotic drugs showed an upward trend year by year.Conclusion In the past 5 years,the use of narcotic drugs and the first class of psychotropic drugs in inpatient pharmacy of the hospital are basically rreasonable, but it still needs to continuously strengthen the knowledge management of narcotic drugs and the related training, so as to ensure safe and effective use of medication in patients.

As hepatic fibrosis and cirrhosis have chronic progressive process,the assessment of fibrosis is of great significance for making appropriate treatment.It is divided into two categories,which includes invasive and noninvasive assessing methods.As a noninvasive method,magnetic resonance shows prospect in many aspects.This article is a review of magnetic resonance imaging in the assessment of hepatic fibrosis and cirrhosis.

OBJECTIVE： To develop a method of thin－ layer chromatographic scanning to determine the content of puerarin in Jiangtang pill METHODS： Silica GF254 thin－ layer was used， and the mobile phase consisted of chloroform－ methanol－ water(7∶ 2 5∶ 0 25) with the detection wave－ length of 254nm and the control wave－ length of 370nm RESULTS： The linear range of puerarin was 0 4～ 2 0μ g The mean recovery was 99 40％ (n=5) with RSD of 1 37％  CONCLUSION： This method is accurate， reliable and can be used for the determination of puerarin in Jiangtang pill

Objective Galangin is a natural flavonoid with antineoplastic activity .SIRT1 is an important member of Sirtuin family which parcitipate in many physiological process .The aim of this study was to investigate the effect of SIRT 1 on HepG2 cell apop-tosis induced by galangin . Methods HepG2 cells were pre-treated with SIRT1 inhibitor EX-527 for 2 hours, and then galangin for 24 hours.DMSO solvent control group, EX-527 treatment group, galangin treatment group and EX-527 and galangin co-treatment group were established.Hoechst 33342 staining, flow cytometry and western blot were performed to detect the apoptosis of HepG2 cells.After regu-lating the expression of SIRT1 in HepG2 cells with RNA interference and transfection of exogenous genes , these cells were treated with ga-langin for 24 hours.Negative control group , vector control group , SIRT1 knock down group , blank control group , blank vector group ,and SIRT1 upregulation group were established .Western blot and Flow cytometry were performed to detect the apoptosis of HepG 2 cells. Results The apoptosis rate and the gray level ratio of shear band of PARP 1 and GAPDH that of galangin group [(11.62± 0.55) %, 0.89±0.01]and EX-527+galangin group[(25.75±0.61) %, 1.15±0.06] were all increased(P<0.01),when these were compared with DMSO solvent control group [(2.49±0.22) %, 0.06±0.00];and those in EX-527+galangin group were also markedly increased compared with galangin group (P<0.01).The result of western bolt was that the gray level ratio of PARP 1 and GAPDH of SIRT1 knocked down group(0.06±0.01) was markedly decreased compared with vector control group (1.11±0.05)and without adenovi-rus infection group (1.10±0.04)(P<0.01).The apoptosis rate and the gray level ratio of shear band of PARP 1 and GAPDH that of SIRT1 knocked down group were markedly increased compared with vector control group and without adenovirus infection group ( P<0.01).The gray level ratio of PARP1 and GAPDH of SIRT1 up-regulated group (1.63±0.04) was markedly increased compared with blank control group (0.89±0.02) and without plasmid transfection group (0.87±0.03) (P<0.01).The apoptosis rate and the gray lev-el ratio of shear band of PARP 1 and GAPDH that of SIRT1 up-regulated group were markedly decreased compared with blank control group and without plasmid transfection group (P<0.01). Conclusion SIRT1 inhibited galangin-induced apoptosis in HepG2 cells.

Objective To analyze the examination results of external quality assessment(EQA),at all levels of iodine deficiency disorders(IDD) net work laboratories in Ningxia from 2002 to 2012,and to provide a reliable laboratory quality assurance for surveillance and control of IDD.Methods The data of IDD network laboratories at Ningxia provincial,municipal and county levels from 2002 to 2012 were collected and analyzed.Results Both of the response rate and qualification rate of salt iodine and urinary iodine laboratories at the provincial level were 100％ in the past 11 years.The response rate and qualification rate of salt iodine laboratories at municipal level were also 100％ ; the response rate of urinary iodine was 100％ since 2005,and the qualification rate had been 100％ for six years since 2007.The response rate of salt iodine at county level had been 100％ since 2004,and the qualification rate had been 100％ for four years since 2009.Conclusions IDD network laboratory in Ningxia Province runs good,and the quality control measures are solid and effective.

ObjectiveTo investigate the diagnosis and operative procedure for spontaneous perforation of congenital choledochal cyst in children. MethodsThe clinical data of 16 cases with spontaneous perforation of congenital choledochal cyst were analysed retrospectively.ResultsAll cases were under 4 years old with a mean age of 23 months. Abdominal distension, pain, vomiting, fever and diffuse tenderness were present in all patients. The preoperative diagnosis was established by paracentesis in ten patients. Abdominal sonography and CT found a cyst in 5 of the 10 cases reviewed. In 11 cases (68.7%), the site of perforation was found on the confluence of common bile duct and gallbladder cystic duct. T-tube drainage was used as a transition measure. All patients recovered uneventfully. Radical resection was performed in about three months after the initial operation. ConclusionsThe obstruction of the bile duct and poor blood supply to the choledochal cyst are major causes leading to perforation. Routine abdominal paracentesis should be carried out for a small child with peritonitis and general abdominal tenderness, especially on the right upper quadrant.T-tube drainage should be adopted as an emergent procedure to tide the patient over the crisis followed by elective choledochal cyst resection and bile duct reconstruction.

Objective To study clinical factors about thrombosis in coronary stents.Methods We reviewed 571 patients who underwent percutaneous coronary intervention(PCI) and thrombosis in coronary stents happened in 5 patients.The clinical data and angiography results and anti-thrombus treatment about 5 patients have been studied.Results Thrombosis in stents had been happened in 6 lesions of 5 patients with acte coronary syndrom.3 lesions were C type.Drug-eluting stents had been deposited in 4 lesions.The cause of thrombosis in stent may be imcomplete stent expansion in 1 lesion and imcomplete apposition in 2 lesions and imcomplete treatment of anti-thrombu in 2 patients.Conclusion Our results show that thrombosis intrastent probably correlate with following factors:(1) Acue coronary syndrom.(2) Long lesion,imcomplete stent expansion, imcomplete apposition and drug-eluting stents.(3) Imcomplete treatment of anti-thrombus.

Objective To summarize and discuss the characters of intracranial ring-enhanced metastatic tumors enhancedly scanned by MRI with ultra-low field.Methods Retrospective study was made of enhanced MRI characters of intracranial ring-enhanced foci in 19 cases diagnosed by clinics and operative pathology.Results Of all 19 cases there were altogether 60 foci,including 15 cases of metastatic tumor with 52 foci,among which there were 39 ring-enhancement,13 even nodular enhancement accompanied by 2 soft mater emhancement,1 cerebral abscess case with ring-enhancement in all 3 foci,1 case cysticercosis of brain with 3 ring enhanced foci accompanied by intraparietal cephalomere enhaucement.In 2 cases of ostrocytoma,mild ring-enhancement could be seen in 1 case of Ⅱ astrocytic tumors,petaling ring enhancement in 1 case of Ⅲ anaplastic astrocytoma.Conclusions The specific shape showed by MRI provides important information for diagnosing intracranial ring-enhanced metastatic tumors.Correct diagnosis can be made in most cases with medical history,age of patient and location of focus.