Cbiective: To seek for effective nursing measures with the view of reducing nooocmial infection caused by methicillin resistant staphlococcus aurcus (MRSA). Method: The factores associated with nosocomial infection caused by MRSA were analysed on 205 cases from ICU during Jan. ～Jun 2000. Results: 88.6% of staphyloooccus aureus were MRSA in ICU. The percentage of nosocomial infection caused by MRSA was 7.3%. Conclusions:The rate of nosocomial infection causes by MRSA could be effectively reduce. Following proper measures were suggested:sterilization, isolation,nursing of intubation and nanagement of respiratory tract