Objective To observe the efficacy of Shuilongjian in treating cerebellar infarction, and compare with the pure western medicine. Methods 67 inpatients with cerebellar infarction enrolled were divided into two groups according to the method of random digits table, 36 cases in the treatment group and 31 cases in the control group. The control group was given 500 mL dextran by venoclysis, once a day. The treatment group was given Shuilongjian as an additional drug. The therapeutic effect was evaluated according to the nerve function and the total capability in dealing with daily activities. Result All the 67 cases of cerebellar infarction were included in the analysis. The effective rate of the treatment group was better than that of control group with 83.3% and 58.1% (P

OBJECTIVE:To investigate advantages and disadvantages of preexisting metal post,casting metal post,ceramic post,and fiber post for clinical application,and to evaluate mechanical function,esthetical performance,and biocompatibility of fiber post.METHODS:Articles were retrieved with the key words of "fiber post,post-core restoration,dental materials,cement material,binder" in both English and Chinese between January 1990 and October 2008.Inclusion criteria:Articles addressing clinical application of fiber post for repairing residual root and crown were included.Exclusion criteria:Duplicated studies or Meta analysis was excluded.A total of 24 articles were included to investigate mechanical function,biocompatibility,and stickiness and retention of fiber post.RESULTS:Traditionally,metal post was easily folded and corrosive; in addition,esthetical performance and biocompatibility were still dissolved.Intension,hardness,esthetical performance,corrosion proof,fatigue resistance,and biocompatibility of fiber post were superior to those of traditional metal post.Furthermore,fiber post was able to highly adhere to root canal dentin via resin splicing agent,which could prolong useful life of dental prosthetic restoration,reduce root folded onset,and benefit for dental storage and repairing.Light mass of fiber post was another advantage compared with metal post.If the repair was failure,fiber post was easily taken out and reused.The combination of fiber post and resin nucleus was beneficial for dental prosthetic restoration which was highly closed to original structure of natural teeth.CONCLUSION:Fiber post was characterized by suitable elastic modulus,great esthetical repairing effect,reliable stickiness,easy identification and removal,high achievement ratio of repairing,and convenient operation; therefore,fiber post was a new and ideal material for clinical application.

Objective To observe the effect of finger-pressing combined with conventional rehabilitation therapy on the recovery of upper limb function after stroke.Methods A total of 60 cerebral stroke patients were randomly divided into an experimental group (n =30) and a control group (n =30).All patients were treated with conventional anti-symptomatic drugs but no anti-spasticity ones.The experimental group was given conventional rehabilitation and finger-pressing therapy,while the control group was given conventional rehabilitation only.Both groups were measured the motor function,using the upper-extremity portion of the Fugl-Meyer Scale,and the mean integrated electromyography (iEMG) output of biceps and flexor carpi radialis after the first finger-pressing treatment and 1 month later,so as to observe the immediate and continuous effects of finger-pressing therapy respectively.Results After the first session of finger-pressing therapy,the average Fugl-Meyer score(FMA) (12.63 ± 4.64) of the experimental group was significantly higher than in a pretest (12.13 ± 4.88) (P ＜ 0.05),while the iEMG of biceps (41.64 ± 9.22) and flexor carpi radialis (37.06 ± 7.02) were lower than before (P ＜ 0.01).One month after the treatment,compared with the control group,the average FMA (25.17 ± 5.93) and iEMG of biceps(34.42 ± 7.55) and flexor carpi radialis sEMG(30.63 ± 5.54) in the experimental group were significantly improved (P ＜ 0.01).Conclusions Finger-pressing therapy has significant and immediate effects in improving the upper extremity spasticity of stroke survivors.Combined with conventional rehabilitation therapy it can effectively reduce the upper extremity spasticity in stroke patients and significantly improve the upper extremity function.The combination is superior to conventional rehabilitation alone.

BACKGROUND:Core decompression can delay early osteonecrosis of the femoral head, but cannot completely repair the necrotic femoral head. Eventualy, femoral head colapse, even bone necrosis, wil occur. OBJECTIVE:To explore the curative effect of implantation of gelatin sponge carrying Foxc2-transfected bone marrow mesenchymal stem cels on the repair of experimental femoral head necrosis in rabbits. METHODS:Forty New Zealand white rabbits were selected, and femoral head necrosis models were prepared successfuly in 24 of 40 rabbits. Then, model rabbits were randomized into four groups: blank control group (n=4) with no treatment, core decompression group (n=4), GFP group (n=8) subjected to core decompression and implantation of gelatin sponge carrying GFP-transfected bone marrow mesenchymal stem cels, and Foxc2 group (n=8) subjected to core decompression and implantation of gelatin sponge carrying Foxc2-transfected bone marrow mesenchymal stem cels. At 1, 2, 4 weeks after implantation, ELISA was used to detect Foxc2 protein levels in the transplanted region. At 4, 8, 12 weeks after implantation, MRI scan of the hip was performed, and femoral head tissues were taken and sliced into sections for hematoxylin-eosin staining to observe bone growth. At 12 weeks after implantation, histomorphometry measurement and transmission electron microscope observation were carried out. RESULTS AND CONCLUSION:At 1, 2, 4 weeks after implantation, Foxc2 was highly expressed in the femoral head in the Foxc2 group, which was significantly higher than that in the GFP group. At 4, 8, 12 weeks, only a few of new bone formed in the core decompression group and GFP group; at 12 weeks, fibrous tissues formed in the decompression channel. New bone formation was evident in the Foxc2 group, and at 12 weeks, the necrotic region was repaired completely. MRI findings showed normal femoral head morphology and signals in the Foxc2 group at 12 weeks, but there were decreased signals of the femoral head in the core decompression group and GFP group. These findings indicate that Foxc2-transfected bone marrow mesenchymal stem cel transplantationvia core decompression has good curative effects on experimental femoral head necrosis in animals.

Objective To explore the effects of motor imaginary therapy combined with occupational therapy on the function of upperlimbs hands and activities of daily living for stroke patients with hemiplegia. Methods 62 stroke patients with hemiplegia were divided intoobservation group (n=31) and control group (n=31). Both groups were treated with basic medication and occupational therapy while the observationgroup was treated additionally with motor imaginary therapy. The function of upper limbs and hands was assessed by Fugl-MeyerAssessment (FMA), and activities of daily living was assessed by Functional Independence Measurement (FIM) before and 2 months aftertreatment. Results There were significant difference between the two groups in the scores of FMA in the function of upper limbs and hands,and FIM 2 months after the treatment (P<0.01). Conclusion Motor imaginary therapy combined with occupational therapy can effectivelyimprove the functional outcomes of upper limbs and hands for stroke patients with hemiplegic, and can even effectively improve the functionalactivities of daily living.

OBJECTIVE: To compare the hemostatic effects of local packing of Nasopore combined with hemocoagulase injection and local packing of Nasopore combined with saline injection for postoperative management of functional endoscopic sinus surgery by a double-blind, randomized control clinical trial. METHOD: Sixty-eight cases of chronic sinusitis needed functional endoscopic sinus surgery were randomly divided into the experimental group of 40 cases and control group of 28 cases, respectively. For the experimental group, 1 U of hemocoagulase dissolved in 0.5 ml saline was injected into Nasopore which was packed into the nasal cavity after operation. For the control group, 0.5 ml of saline was injected. The postoperative bleeding of the two groups were scored by visual analogue scale. RESULT: There was statistically significant difference between the bleeding VAS scores assessed 6 hours and the ones assessed 1, 2 and 3 days after the operation in the control group (P < 0.05). There was the statistically significant difference between the bleeding VAS scores of experimental group and control group assessed 6 h after the operation (P < 0.05). CONCLUSION The hemocoagulase may improve the hemostatic effect of Nasopore 6 hours after the operation by combined injection with Nasopore as nasal cavity packing.
Bandages ; Batroxobin ; administration & dosage ; Double-Blind Method ; Endoscopy ; Epistaxis ; therapy ; Female ; Humans ; Injections ; Male ; Nasal Cavity ; surgery ; Treatment Outcome

Objective To observe the effect of horizontal multi-joint arm continuous passive motion (CPM) training on muscle tension and strength of biceps brachii of patients with stroke. Methods 60 patients with stroke were divided into treatment group (n=30) and control group (n=30). All the patients accepted routine medication and rehabilitation. The treatment group accepted horizontal multi-joint arm CPM training in addition. Their surface electromyography of biceps brachii was analyzed with surface electromyography analysis system: tension and strength before and after treatment. Results The tension and strength of biceps brachii improved in both groups after treatment (P<0.05), and improved more in the treatment group than in the control group (P<0.05). Conclusion The horizontal multi-joint arm CPM training may relieve the muscle tension and enhance the strength of biceps brachii after stroke

Objective To probe into the medical experience in inpatients by tracking method,in order to provide the basis for continuing quality improve.Methods The tracking group was established,the patients was tracking and selected in medicine department,surgery departments,gynecology and obstetrical departments randomly from July to December 2015,and improve continually according to the feedback questions by patients,and then compared patient′s satisfaction.Results The members of tacking group interviewed patients 180 cases totally,and the patients had 152 times asked questions which included the contents as diet, environment,education,services and facilities. After improving continually,the questions asked by patients reduced from 105 times (in the third season) to 47 times (in the fourth season);the patient′s satisfaction improve from 97.39% to 99.22% (χ2=15.34,P<0.01).Conclusions The tacking method is used to daily nursing management for improving patient′s satisfaction,which can provide evidence to improve nursing quality.

Basal cell carcinoma has a low mortality rate, but its multiple occurrence, recurrence and metastasis have caused problems for patients and clinical work. In recent years, with the in-depth study of the tumor microenvironment in basal cell carcinoma, previous understanding and treatment concepts for basal cell carcinoma have been changed. This article focuses on the role of tumor microenvironment in the occurrence and development of basal cell carcinoma, and reviews the treatment method based on this.

BACKGROUND:Cell death and neuroinflammation are two important targets in the treatment of spinal cord injury.Pyroptosis is a programmed cell death closely related to neuroinflammation and targeted inhibition of pyroptosis after spinal cord injury is a promising therapeutic strategy. OBJECTIVE:To summarize the molecular mechanism,positive and negative regulatory factors and therapeutic strategies of pyroptosis in spinal cord injury. METHODS:The search terms were"spinal cord injury,pyroptosis,nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3),Caspase,Gasdermin D(GSDMD),IL-1β,IL-18"and 93 English literatures included in PubMed and Web of Science were finally selected for review. RESULTS AND CONCLUSION:As a newly discovered programmed cell death,pyroptosis has been shown to play an important role in the secondary injury stage after spinal cord injury.Among the regulatory factors of pyroptosis after spinal cord injury,CD73,NRF2,GDF-11,dopamine,FANCC and miR-423-5P could inhibit pyroptosis,while TLR4 and Aopps could promote pyroptosis.In terms of treatment,the active ingredients of traditional Chinese medicine(paeonol,tripterine,betulinic acid,piperine,kaempferol,and camptothecin),exosomes of various cell origins,and some drugs(metformin,topotecan,lithium,zinc,and carbon monoxide-releasing molecule 3)can effectively inhibit pyroptosis and reduce secondary spinal cord injury,but the toxicity and specific dose of these drugs need to be further studied.The specific molecular mechanism by which pyroptosis aggravates spinal cord injury is still poorly understood.The role of non-classical pathways and other inflammasomes is worth further exploration.At present,the research on pyroptosis after spinal cord injury only stays at the animal experiment stage.There are no related clinical studies and no approved targeted therapeutic drugs.(6)The application of pyroptosis after spinal cord injury has great potential,and its specific regulatory mechanism should be further studied in the future to provide a new target for the treatment of spinal cord injury.