Objective To develop Neonate Information Management System for neonate information management in computer.Methods After detailed analysis for demand in neonate management,prototype law was used to develop the program with PowerBuilder9.0 and Micorsoft SQL Server 2000 as tools.Results Neonate Information Management System realized such functions as neonate information input & revision,data inquiry,data statistics,printing,etc.Besides,the operation was simple.Conclusions Neonate Information Management System makes the information input more accurate,and the inquiry more quick and convenient so that the personnel's working efficiency can be greatly enhanced.