Clinical Medicine ; Humans ; Neoplasms ; prevention & control ; Periodicals as Topic ; Research

With the development of computer techniques and medical imaging examining methods , precise radiotherapy is becoming the major direction of radiotherapy for tuomors. Both of tumor control probability and normal tissue complication probability are improved with precise radiotherapy. This paper critically review the value of PET-CT and breathing control in precise radiotherapy for non-small-cell lung cancer (NSCLC).

ObjectiveTo explore the effect of the cognition dysfunction on the stroke rehabilitation.MethodsThe loewenstein Occupational Therapy Cognitive Assessment Battery (LOTCA), Fugl Meyer motor scale, functional independence measure were carried out to evaluate the function of 66 stroke patients before and after rehabilitation.ResultsThe rehabilitation process of motor and independent function of patients who had suffered from cognition dysfunction was latered than that of patients who had not suffered from cognition dysfunction, and cognition dysfunction had a closed relationship with stroke rehabilitation.ConclusionCognition dysfunction directly has a influence to stroke rehabilitation, both special and comprehensive methods in rehabilitation process, improve cognition function, decrease its influence to the stroke rehabilitation.

Objective: To study the dosage application of herbs in class formulas of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy (Taiping Huimin Hejiju Fang), Essential Recipes for Emergent Use Worth A Thousand Gold (Beiji Qianjin Yao Fang) and Records of Approved Cases of Ancient and Recent Times (Gujin Luyan) and their actions on depression. Method: According to the dosage proportion of different herbs in the three formulas in the three books, two methods were adopted in terms of decocting different herbs separately and mixing them thereafter(group of decocting separately) as well as extracting after decocted all the herbs together (group of decocting together). Classical anti-depression mice models--forced swimming and tail suspending experiments were observed. The data of immovability time of mice were analyzed by statistics. Result: All the class formulas of KaixinSan which have the same medication but different proportion in the three medical books can reduce the immovability time of mice in forced swimming and tail suspending experiments. But the action of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy was prominent, and the action of the group of decocting together was superior to that of separated decocting. There was significant difference between the group of decocting together in low dosage and the controlled one (P

ObjectiveTo explore the effects of extended nursing intervention (ENI) in nursing ability of discharged patients with intubation of T-tubes.Methods Eighty-two patients with biliary diseases discharged with intubation of T-tubes were equally divided into two groups.The patients in the experiment group were treated with ENI and those in the control group were treated with conventional nursing.Each group received routine nursing and health education before discharge.All patients were followed up by a self-designed written questionnaire.Data regarding patients’ compliance behavior,knowledge of the diseases and satisfaction were collected and analyzed.Result Significant differences were observed between the two groups,the patients in the experiment group exhibiting better compliance behavior,their knowledge of their diseases improved and the rate of satisfaction higher (P<0.05). Conclusion ENI may be effective for the discharged patients with intubation of T-tubes to improve their compliance behavior, enhance their knowledge of their diseases and raise the rate of satisfaction.

OBJECTIVE: To investigate the kinetic and thermodynamic characteristics of adsorption of avilamycin on silica gel. METHODS: By measuring the adsorption of avilamycin on silica gel at different temperatures, the adsorption kinetics curves and adsorption isotherm were drawn, and the kinetics and thermodynamic parameters were studied. RESULTS: The adsorption of avilamycin on silica gel could be described well by Pseudo-second-order model. The adsorption process had feature of shrinking nonreactive core model, and the internal diffusion was the main rate-limiting step. The equilibrium adsorption data of avilamycin on silica gel fit the Langmuir isotherms well. The thermodynamic parameters were as follows:change in entropy (ΔS) was 108.115 2 J·mol-1·K-1, change in enthalpy (ΔH) was 24.654 6 J·mol-1, and changes in free energy (ΔG) were -8.752 9, -8.104 3, and -7.455 6 J·mol-1 at 309, 303 and 297 K, respectively. CONCLUSION: The RESULTS: of this study provide a theoretical basis for further study on the isolation and purification of high purity avilamycin by silica gel.

OBJECTIVE: To optimize the formulation of avilamycin self-microemulsifying drug delivery system (SMEDDS) using central composite design-response surface method and evaluate its quality. METHODS: The compositions of avilamycin SMEDDS were screened by solubility experiment and self-emulsifying grading test. The formulation was optimized using Design Expert Software, taking particle size and Zeta potential as dependent variables and the usage amounts of oil, surfactant and cosurfactant as independent variables. RESULTS: The optimized formulation was quickly and conveniently obtained as follows: 36.67% propylene glycollaurate, 42.83% cremophor RH40 and 20.50% diethylene glycol monoethyl ether.The average diameter of the preparation was (28.34±0.06)nm, the Zeta potential was (-1.98±0.24)mV and PDI was (0.15±0.005). CONCLUSION: The central composite design and response surface method is useful for the formula optimization of avilamycin self-microemulsifying drug delivery system.The prediction accuracy of the established mode1 is good.

Objective The significance of serum cytokine profile in coronary heart disease patients have been evaluated by observing the variation cytokines Methods The serum IL-1 a,IL-1 ?,IL-2,IL-4, IL-6 ,IL-8,IL-10,VEGF,IFN-?,,TNF-?,MCP-1 and EGF in 76 patients and 26 matched healthy volunteers have been observed.Serum cytokines had been measured by protein chips methods in EVIDENCE 180 automatic biochips analyzer and cytokine profile were got by bioinformatics.Results The serum level of IL-1?,IL-6,IL-8,and TNF-? were (4.32?8.14) ng/L ,(13.16?16.81) rig/L,(375.53?292.14) ng/L,(15.46?15.38) ng/L respectively,which increased obviously in patients (P

Objective To establish a rapid assay for genotyping of IL-6-597G/A and-572G/C polymorphisms by duplex real-time PCR assay.Methods One pair of primers and two pairs of fluorescent hybridization probes had been used to genotype two mutation sites in the promoter region of IL-6 gene by fluorescent resonance energy transfer and melting curves.Results Duplex real-time PCR method for genotyping of two mutation sites simultaneously had been developed and 123 health people samples were analyzed by this new method.The results showed that three genotypes were found in IL-6 gene-572G/C polymorphisms.They were GG,GC and CC genotypes.IL-6 gene promoter-597G/A polymorphism analysis showed 4 cases displayed GA genotype and other possessed GG genotype.No AA genotype had been found.Conclusions Duplex real-time PCR method is simple and fast.It provided an accurate and economic method which is suitable for clinical gene genotyping.

Aim To observe the improvement effects of parecoxib on ventricular remodeling after acute myocardial infarction in rats and its influence on PI3K/Akt signaling pathway.Methods Forty male Sprague-Dawley rats were randomly divided into five groups(n=8):sham operation group (group S), ventricular remodeling model group(group R), low dose of parecoxib group(group P1), middle dose of parecoxib group(group P2), and high dose of parecoxib group(group P3).A myocardial infarction model was established by ligating the left anterior descending branch(LAD) of coronary artery in group R, group P1, group P2 and group P3.One day after the operation,the rats were given intraperitoneal injection of 4,8,12 mg·kg-1 parecoxibin Group P1, group P2 and group P3,respectively, for two weeks.The same volume saline was given in group S and group R.Four weeks later, LVSP, LVEDP,+dp/dtmax,-dp/dtmax were monitored.The hearts were harvested to calculate left ventricular hypertrophy index.The pathological change of heart was examined with an optical microscope.The expressions of atrial natriuretic peptide(ANP) mRNA and brain natriuretic peptide(BNP) mRNA were detected by RT-PCR.The expression of PI3K,Akt,P-Akt and caspase-3 was detected by Western blot.Results Compared with group S, the cardiac function was decreased, the left ventricular hypertrophy index, the expression levels of ANP,BNP mRNA, caspase-3 were increased, and the expression levels of PI3K, P-Akt were reduced in group R(all P<0.05).Compared with group R, the cardiac function was ameliorated, the left ventricular hypertrophy index were reduced in group P2 and group P3(all P<0.05).The expression levels of ANP,BNP mRNA, Caspase-3 were decreased, and the expression levels of PI3K and P-Akt were increased in group P1,group P2 and group P3(all P<0.05).Conclusions Middle and high doses of parecoxib can mitigate the process of ventricular remodeling after myocardial infarctionand improve the myocardial function, and its underlying mechanism may be related to activating PI3K/Akt signaling pathway.