Objective To analyze the clinical efficacy and safety of holmium laser lithotripsy under ureteros-copy in the treatment of ureteral calculi .Methods The clinical data of 160 patients with ureteral calculi were retro-spectively analyzed .All patients received the epidural or general anesthesia surgery ,guide wire was inserted through ureteroscopy,holmium laser lithotripsy line,postoperative indwelling double J tube 2-4 weeks.Results Of 160 cases, a single stone crushing operation was 94.37%;mean operative time was 51min.All patients had mild hematuria,3 ~4d may disappear.By 1 to 3 months follow-up,stone clearance rate was 97.5%.The success rate of gravel for surgical ureteral calculi was 70.27%, and middle and lower ureteral stone gravel-time success rate was 99.20%.Conclusion Holmium laser lithotripsy under ureteroscope in the treatment of ureteral calculi is safe ,effective,and has minimally invasive,fewer complications.

Objective To master the status of schistosomiasis transmission in Xinjiangkou Township,Sonzi City,from 2004 to 2013. Methods The data of schistosomiasis epidemic situation were collected and analyzed statistically in Xinjiangkou Town-ship,Sonzi City,from 2004 to 2013. Results From 2004 to 2013,the areas with Oncomelania hupensis snails were 193.2-185.3 hm2,and the highest density of infected living snails was 0.000 70 snail/0.1 m2 in 2007. However,after 2011,no infected living snails were found. The positive rate of blood tests was 9.46%and schistosomiasis infection rate was 7.36%in 2005,and the posi-tive rate of blood tests was 3.27%and schistosomiasis infection rate was 0.57%in 2013. There were 7 cases of acute schistosomia-sis in 2004 and 2005,respectively,and there were no acute schistosomiasis patients after 2006. The schistosome infection rate of cattle was 18.27%in 2004,and after 2007,the infection rate decreased below 5%. In 2013,all the cattle were obsoleted. Conclu-sion The schistosomiasis transmission has reduced to a low level in Xinjiangkou Township. However,to realize the aim of schisto-somiasis transmission controlled,the comprehensive control measures mainly based on infectious source control should still be strengthened.

Objective To investigate the lethal effects of energy controllable steep pulses on U_(14) cervical cancer in mice. Methods A total of 48 female BALB/C mice were inoculated subcutaneously with the solution of U_(14) cervical cancer cells line at the right hind limb. The histomorphological changes were observed and the suppressive curve of the tumor was analyzed between experimental group (n=26) treated with steep pulse stimulation and control group (n=22) without any treatment. Results Steep pulses electrical field could selectively injure tumor cells and inhibit cell proliferation. In the experimental group, the phenomena of pyknosis, karyorrhexis and karyolysis of tumor cells were observed by light and electron microscope and got worse as time prolonged. Conclusion Energy controllable steep pulses have a lethal or inhibitory effects on cervical cancer cells.

Microsoft Kinect based virtual reality system with low price and the characteristics of human computer interaction , has been increasingly explored in clinic works including rehabilitation , measurement , assessment , recognition and application innova-tion.In this paper, the Kinect related studies of nervous system diseases will be reviewed , additionally, we will list several study limi-tations to provide a reference for further studies .

The credit system adjusts the newly-built teaching management system under the development of market economy.The accomplishment of credit system will bring great impact on the traditional class management of the college students such as the idea,the type,the function,the content and the method of management.We should explore the new method of college students' management under the credit system and establish the students' management system that can adjust the credit system.It plays important roles in improving the college teaching quality.

To investigate the solubility and thermodynamics parameters between brucine and β-cyclodextrin polymer (β-CDP) under the condition of different temperature and pH solution. Methods:The solubility effect ofβ-CDP was performed by the phase-solubility method and the inclusion constant ( Kc ) and thermodynamic parameters were calculated. Results:The Kc at the differ-ent temperature of 25℃,37℃ and 45℃ was 88. 38,349. 29 and 641. 79 L·mol-1 , respectively, and that at the pH of 4,6. 8 and 10 was 490. 66,111. 85 and 58. 86 L·mol-1 , respectively. The solubility of brucine was increased linearly with the increase of β-CDP concentration in the AL-type phase solubility curve. The inclusion constant and solubilization of β-CDP were both higher under acidic conditions. Conclusion:The solubility of brucine in water can be improved byβ-CDP, and brucine andβ-CDP can form stable inclu-sion complexes with molar ratio of 1∶1. The inclusion compound can form spontaneously (ΔG<0), and high temperature and low pH value can enhance the formation of the inclusion compound.

Stroke is one of the major diseases that threaten human health, early diagnosis and treatment are very important for stroke. Carotid intima-media thickness (CIMT) is measured noninvasively to diagnosis stroke, and it is a independent predictor for stroke because its thickening can timely predict the incidence and development of stroke. As an important predictor of cardiovascular disease, more and more attention is played on CIMT. In this review, we will make a summary on the important role of CIMT in stroke and the mechanisms of carotid intima-media thickening in stroke as well as the potential use of traditional Chinese medicine in treating carotid intima-media thickening.
Animals ; Carotid Arteries ; drug effects ; physiopathology ; Carotid Intima-Media Thickness ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Stroke ; diagnosis ; drug therapy ; physiopathology

Arthritis, Juvenile ; drug therapy ; Glucocorticoids ; adverse effects ; pharmacology ; therapeutic use ; Humans

BACKGROUND: The design of the microstructure of human bone is in fact to construct a model, which could characterize the connecting-porosity cell frame structure. As the porosity structure is represented as irregular curve, and this irregularity has close relationship with the bone function, does the fractal theory effectively find the irregularity containing in the irregular structure?OBJ ECTIVE: To analyze the microstructure of human bone by applying the fractal property, and construct the 3D model that has structural similarity to the natural bone. With the help of Rapid Prototyping technology, a new bionic technique instead of traditional modeling method is presented to model artificial human bone.DESIGN: Computer aided bionic design.SETTING: Biomaterials and Engineering Center of Wuhan University ofTechnoiogy.MATERIALS: The experiment was carried out in the Biomaterials and Engineering Center of Wuhan University of Technology from January to June 2005. The material is the original gray chart of hip joint of one healthy middle-aged male.METHODS: The contour of the human bone microstructure was obtained by exaltation and extraction of the grey chart.B-spline technique was used for vectorization. ①The fractal theory was adopted to compute the fractal dimension of typical aperture structure and the result was represented by dimensions (D=2s, s is the slope of fitting line) to find the inherent relation among apertures. ② Monte Carlo method was used to generate the two-dimensional model of microstructure of bone with the appropriate porosity. The 3D model was manufactured by rapid prototyping technology.MAIN OUTCOME MEASURES: ①Fractal dimension of porous structure of human bone; ② Results of 2D and 3D model of the microstructure of human bone.RESULTS: ①The fractal dimensions of some representative apertures were between 1.14and 1.28. The fractal dimensions of these micro-apertures are rather close, which testified the self-similarity in the edge contour of the microstructure of human bone. ②3D model was generated by cumulating the plane model layer by layer with the rapid prototyping technology. If the high porosity of plane model was ensured, the porosity and connectivity of 3D model could meet the high requirement. Through the computer simulating, the porosity of the model was greater than 40%, which meets the design requirement.CONCLUSION: Fractal theory is applied in the construction of 2D model of human bone based on the requirements in bionic design of the microstructure model of human bone. The fractal characteristics of the grey chart of human bone and the edge contourof its typical micropore are analyzed. The software suitable for 2D tissue engineered bionic microstructure of human bone is developed with VC++, meanwhile, 3D cell scaffold model is constructed by cumulating the planer model, which meets the human bone functions.

Objective To observe the effects of autologous myoblast transplantation on endplate regeneration and neuromuscular function restoration following direct nerve implantation (DNI) in rats so as to offer experimental basis for the use of myoblasts in neural regeneration area and further lay foundation for the research using myoblasts as transgenic carriers. Methods A total of 20 male SD rats were randomly divided into experimental group and control group,with 10 rats in each group.Models of DNI in rat gastrocnemius were established.The experimental group was injected with primarily cultured autologous myoblasts to the DNI location,while the control group was injected with isometric medium without autologous myoblasts.The effects of myoblasts on the neuromuscular function recovery following DNI were studied by detecting the tibial functional index (FTI),neuro-electrophysiology and pathohistology.Results The experimental group displayed faster tibial nerve function recovery than the control group (P ＜ 0.01 ).The peak to peak value (PPV) of gastrocnemius neuro-electrophysiology,area under the curve and regenerated endplate number of the experimental group had statistical significances as compared with the control group ( P ＜ 0.01 ). Conclusion Myoblast autotransplantation accelerates the recoveryof neuromuscular function after rat DNI and increases the number of the regenerated endplates.