Objective To investigate the clinical efficacy of laparoscopic myomectomy surgery and open myomectomy surgery for the patients with uterine fibroids.Methods 78 patients with uterine fibroids in our hospital were divided into observation group and control group by random serial number,and each group had 39 cases.The observation group was given laparoscopic myomectomy,while the control group was given open myomectomy surgery.The average time,average blood loss,postoperative exhaust time and average postoperative hospitalization days were compared between the two groups.Results The operative time,blood loss,postoperative exhaust time and hospital stay time of the observation group were (113.3 ± 15.1) min,(50.5 ± 27.5) ml,(19.5 ± 5.1) h and (4.6 ± 0.5) d,while those in the control group were (61.5 ± 12.7) min,(100.9 ± 35.7) ml,(37.6 ± 4.9) h and (7.7 ± 0.6) d,the differences were significant between the two groups (t =11.79,10.35,8.06,7.11,all P ＜ 0.05).Conclusion Compared with open myomectomy surgery,laparoscopic myomectomy can not only shorten the hospital stay,but also reduce the time of discharge,and it is worth to be further promoted in clinical.

The optimal bariatric surgery is still not acquired although the obesity epidemic has become a worldwide problem. The recentness studies on obesity focused on mass balance regulated by central nervous system, in which an important circuit is vagus nerve. This review provides progress on obesity mediated by vagus nerve simulation and vagal blocking.

Sedation monitoring of the critically ill children must be individualized and continuous. Electroen-cephalography-derived method———bispectral index( BIS) is one of the most widely used objective sedation monitoring methods in recent years,permitting continuous monitoring. Some studies reported the correlations between BIS and the clinical scales were varing. The BIS value of 70 or so may distinguish between adequate and inadequate sedation. BIS has some unique advantages over other objective methods. Many factors may influence the right interpretation of BIS. On the whole, the researches and applications of BIS are mainly in adults, the experience is relatively less in critical ill children. This article reviews the studies of BIS in critical ill children for sedation monitoring.

Food intake,energy expenditure and body adiposity are homeostatically regulated.Hypothalamus and brainstem are key brain regions of the system.In the state of hunger or satiety,the neural and hormonal messages from the gut regulate energy homeostasis through reflection or direct effect on the hypothalamus and brainstem,Which is referred to as brain-gut signaling.New researches on the special physiological functions of gut hormones are expected to offer a target for anti-obesity drugs.

At present, oncology medical student in our country has many communication problems, such as communication awareness is not strong,the lack of communication,communication is not enough self-confidence and other issues.To improve the communication ability between doctors and patients for the oncology professional medical students:it is the necessary premise for correct implementation of diagnosis and treatment, an effective way to reduce medical disputes, adapt to the demand of the development of higher medical education.And pointed out the effective ways to improve the ability of doctor-patient communication:to set up the doctor-patient communi-cation and tumor department before the internship training course;establishlisten with your heart and professional guidancemode;with teacher actively guiding; learn to empathymode; adhere to the concept of taking pa-tients as the center.

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Objective This study assesses the influence of rizatriptan on calcitonin gene-related peptide (CGRP),proenkephalin (PENK) and cholecystokinin (CCK) mRNA expressions in the trigeminal ganglia of a rat migraine model and investigates the possible mechanisms by which triptans treat migraine.Methods A total of 24 rats were randomly divided into four groups:normal control group (A),migraine model group(B),rizatriptan control group (C) and rizatriptan treatment group(D).Groups C and D were intragastrically perfused with rizatriptan,1 mg/kg per day.After 7 days,nitroglycerin was subcutaneously injected into the buttocks of the groups B and D to induce migraine.Two hours after nitroglycerin injection,the trigeminal ganglia was isolated.CGRP,PENK and CCK mRNA expressions in the trigeminal ganglia were determined using SYBR Green Ⅰ real-time quantitative PCR.Results The copy number of CGRP mRNA (× 107) in 200 ng total RNA of each group was 0.05 ±0.01,1.30 ±0.52,0.23 ±0.12,0.43 ±0.33 ; The copy number of PENK mRNA (× 103) in 200 ng total RNA of each group was 3.30 ± 1.65,0.34 ±0.14,3.91 ± 2.44,0.71 ± 0.13.The copy number of CGRP mRNA in the trigeminal ganglia of group B was significantly higher than that of group A (q =7.854,P ＜ 0.05) ; CGRP mRNA expressions were significantly lower in the trigeminal ganglia of rats in group D compared with group B (q =5.458,P ＜0.05).Compared with group A,PENK mRNA expressions in the trigeminal ganglia of rats were significantly lower in group B (q =4.478,P ＜ 0.05).PENK mRNA expressions were significantly higher in trigeminal ganglia of rats in group C compared with group D (q =4.838,P ＜ 0.05).CCK mRNA expression in trigeminal ganglia of rats was similar among groups.Conelusions Rizatriptan can decrease the expressions of CGRP in the trigeminal ganglia of the migraine rats and exhibits neurogenic inflammation triggered by CGRP.PENK expressions decrease in the trigeminal ganglia of the migraine rats,weaken the analgesic effects of enkephalin.

ObjectiveTo explore activity characteristics of diverse autonomic nervous system of armymen with different mental quality levels during dread emotion processes.MethodsMental Quality Questionnaire of Armymen was used to select participants.The activities of the diverse autonomic nervous system of armymen withdifferent mental quality levels during dread emotion processes were discussed by physiological - psychological experiments.Results ( 1 ) Under neutral condition blood volume pulse (BPV) is greater in low mental quality group( ( -0.87 ±0.64)mm Hg) than in high( -0.28 ±0.24)mm Hg).(2) During dread emotion processes the normalized low frequency spectral component(LF) and skin conductance (SC) are greater in low mental quality group ( (6.54 ± 2.96) nU),(0.78 ± 0.11 ) umho) than in moderate ( ( 1.32 ± 1.25 ) nU,( (0.22 ± 0.15 ) umho) and high ((3.51 ±2.28 )nU,((0.30 ±0.12) umho).(3) During dread emotion processes the recovery time of HR and the average recovery time of skin conductance( SC ),skin temperature( ST),blood volume pulse(BVP) and HR are greater in low mental quality ( 61.58 ± 35.66 ) s,( 36.78 ± 18.58 ) s ) than in high ( ( 22.36 ± 6.87 ) s,(56.87 ± 23.98 ) s).(4) In emotional arousal,and low mental quality (0.88 ± 2.54 ) in neutral conditions change their arousal'was significantly greater than the middle (0.57 ± 2.88) and high psychological quality group (0.15 ± 1.87) ; Low mental quality group (2.17 ±2.39) under the conditions of pleasure in the dread was significantlygreater than the middle ( 1.87 ± 1.45 ) and high psychological quality group ( 1.24 ± 1.66).ConclusionThe findings indicate that armymen with low mental quality is more likely to show corresponding physiological arousal and alert status in face of the neutral or weak emotional stimuli.When facing dread emotional stimuli,they would show stronger physiological arousal mainly basing on the excitement of sympathetic nerve system,and such statuswould last much longer to bring about more fierce pain experience.

OBJECTIVE To get knowledge of the distribution and drug-resistance of Stenotrophomonas maltophilia in our hospital and improve the level of diagnosis and treatment.METHODS The automatic drug sensitive test and the paper spreads medicine sensitive test were carried on to 162 strains of S.(maltophilia) with the index of the VITEK system.RESULTS In all clinical samples,S. maltophilia isolated from phlegm was the most(90%),then was from secretion and swab.The majority of 162 strains were multidrug resistant.But to the(trimethoprim)-sulfamethoxazole and ciprofloxacin,the drug resistance was low((20.4%) and 22.2%,respectively).CONCLUSIONS S.maltophilia is the prevalent pathogen of nosocomial infection in ICU.And most of it are(isolated) from phlegm.So use antibiotics correctly,(reduce) invasive examinations or treatments and strengthen drug-resistant monitoring,are helpful to prevent and control S.maltophilia nosocomial infection.

Objective To investigate the protective effects of luteolin on cerebral ischemia-reperfusion injury in rats.Methods 40 SD rats were randomly divided into four groups:sham group,model group,luteolin low and high dose groups.Each group was given oral administration for 7 days.After 1 h of last administration,the CIRI ( cerebral ischemia-reperfusion injury) group was produced inserting 5-0 line into the internal carotid artery.Then levels of IL-10, IL-1βand TNF-αcontents in myocardial tissues were measured.Meanwhile,infarct size was detected by TTC staining and number of BrdU +and Nestin + were measured by immunohistochemical methods.Results Compared with model group, luteolin could significantly decrease the levels of TNF-αand IL-1βin cerebral tissues(P<0.05),improve IL-10 content in cerebral tissues(P<0.05),and effectively reduce myocardial infarct range(P<0.05).Meanwhile luteolin could improve the expressions of BrdU + and Nestin + in cerebral tissues(P <0.05).Conclusion Luteolin has beneficial effects on rats with cerebral ischemia-reperfusion injury and improves endogenous neural stem cells proliferation.