Objective To explore the influences of Jinganning decoction on the content of CYP2E1 and cytokine IL-6,TNF in rats models of alcohdic hepatic injury.Methos 72 male Wistar clean level rats were randomly divided into 6 groups:blank control group,Jiuganning drug toxicity test group,alcoholic hepatic disease model group,Yiganling treatment group,Jiuganning low dose group,and Jiuganning high dose group.Blank control group was treated with physiological saline;Jiuganning drug toxicity test group was treated with Jiuganning decoction to observe toxicity and side effects.Jiuganning low and high dose treatment group were treated with 17.5 g/kg and 23.5 g/kg crude drug.Yiganning treatment group were treated with 0.206 g/kg crude drug.After 4 weeks'treatment,the content of TNF,IL-6,MDA as well as the activity of CYP2E1 and SOD were measured.Results Compared with the alcoholic hepatic disease model group,the content of IL-6(F=46.281,9.101),TNF and the activity (F=62.537)of CYP2E1 of all treatment group were significantly improved(P＜0.01).The content of SOD(F=19.210)in the rats serum of all treatment group was significantly increased while the MDA(F=34.952)was decreased.All the indexes in the treatment group had significant differences with the alcoholic hepatic disease and model group(P＜0.01).Conclusions The mechanism of Jiuganning decoction can effectively reduce the content of CYP2E1 and IL-6,TNF-a,with the changes of cell physiopathology and the influences of relevant enzymes,reveals the functional routines of the decoction treating hepatic injury:anti-lipid peroxidative,adjusting cytokine's activity,protecting hepatocyte,palliating the hepatocyte inflammation,and easing fibration.

A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.

Objective To study the ankle-brachial index of the diabetic gangrene. Methods ABI of the sixty cases with type 2 diabetes were measured. The results were divided into four groups: normal, gently abnormal moderate abnormal severely abnormal group. Results 30 cases were normal, occupying 50% (P＞0.05), gently and moderate abnormal attained 5 cases (8.33%) and 4 cases (6.67%) respectively, and the rests 21cases were severely abnormal, occupying 35% (P＞0.05).Conclusion The normal ABI was not always indicating type 2 diabetes without the gangrene or tendency.

Animals ; Child ; China ; Dairy Products ; Diet ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Nutritive Value

Objective To study the effect of nutrient intake in different periods of gestation on fetus in-trauterine growth. Methods 239 cases of pregnant women were divided into three groups:(1)10～2 weeks; (2)21～30 weeks; (3)over 31 weeks. Nutrient intake was calculated by computer nutrition system. Fetus intrauterine growth retardance in different periods of gestation was estimated by routine methods. The incidence rate of fetus in-trauterine growth retardance between different periods of gestation and different nutrient intake was compared. Re-suits Group 1, group 2 and group 3 : comparison to cases with < 90 % RDA or > 110 % RDA, the incidence rate of fetus intrauterine growth retardance was higher than that in pregnant women with 110 % - 90 % RDA(P < 0.05).Conclusion Optimal nutrient intake was important to reduce the incidence rate of fetus intrauterine growth retar-dance.

Objective To discuss the effect of correct limb emplacement on the prevention of shoulder pain of patients with cerebral apoplexy. Methods Forty-one patients after cerebral apoplexy with motor dysfunction of upper limbs but with no sensory disability and shoulder pain were randomly divided into the control group (20 cases)and the observation group (21 cases).Both two groups received routine passive activity and massage of limbs.The observation group was given correct limb emplacement based on routine nursing. Then we evaluate the pain of ariticulus humeri when in the full range of anterior flexion movement after two months. Results The incidence of shoulder pain in the control group was 65.0%,which was statistically lower than that of the observation group (19.0%), χ2=8.91,P ＜ 0.01. Conclusion Correct limb emplacement had preventive effect on patients with cerebral apoplexy.

Objective To know the influence of nursing intervention on postoperative anxiety of patients with acute myocardial infarction when cured by pereutaneous tranluminal coronary angioplasty. Methods Di-vided 70 patients with acute myocardial infarction when cured by percutaneous tranluminal coronary angioplasty into the intervention group (40 cases) and the control group (30 cases) randomly. Routine nursing cares was used in the control group, integreted nursing cares was used in the intervention group in addition. Compared the incidence rate of anxiety between the two groups. Results After the nursing intervention, the incidence rate and the score of anxiety in the intervention group was significant better than that of in the control group respectively. Conclusions Integreted nursing cares can effective ameliorate the anxiety condition for patients with acute myocardial infarction when cured by percutaneous tranluminal coronary angioplasty, which can avoid certain related complications, and then promote psychological rehabilitation.

OBJECTIVE: Differential cognition and evaluation of the scientific merit of free radical-induced aging theory in the explanation of aging mechanism.DATA SOURCES: Literatures about free radical-induced aging theory were searched in Medline and Embase by computer from April 1976 to October 2004 with searching words of "free radical, aging, dialectical" and the language of the articles was limited in English, the subjects were the elderly and aging animal.STUDY SELECTION: To select literatures about free radical-induced aging theory for preliminary examines. Quality evaluation mainly examined the authenticity of the data, whether the survey design was rigorous, whether the intervention process was strict, and whether statistical management was reasonable.DATA EXTRACTION: A total of 30 articles about the merit of free radical-induced aging theory in the explanation of aging mechanism were searched, of which 18 experiments were in accorded with the inclusive criteria. In the 12 excluded experiments, 7 articles were the repetitions of same study, and 5 articles were Meta analytic study.DATA SYNTHESIS: Comparative analysis was conducted in the experimental results of aging essence and the prolongation of maximum duration of life explained by free radical-induced aging theory.CONCLUSION: Free radical-induced aging theory has an important biomedical academic merit, but it does not successfully explain the fundamental reason of agingand the essence of aging process.

Encephalopathy secondary to hereditary metabolic diseases leads to high mortality due to the difficulties in early diagnosis and timely treatment.Survivors are often left with severe sequelaes of the nervous system. A considerable number of hereditary metabolic diseases are not thoroughly understood, but pre-clinical or early-clinical diagnosis and treatment can be attempted with MRI which can generally optimize the outcome.

ObjectiveTo explore the clinical curative effect of different methods on anesthesia radical mastectomy. MethodsTo choose 120 patients with breast cancer,and divided into epidural group and general anaesthesia group according to different methods of anesthesia randomly, and monitored the changes of blood pressure, heart rate, blood oxygen saturation, norepinephrine, epinephrine and C-reactive protein of all patients during peroperative period, and analyzed the difference between the two groups. ResultsThe vital sign and level of stress hormone of patients of epidural group during peroperative period had no significant difference( all P ＜0.01 ). The vital sign and level of stress hormone of patients of general anaesthesia group intraoperation were significant different compared to preoperation and post operation( all P ＜ 0.01 ). ConclusionEpidural anesthesia had lighter stress reaction and stable vital sign than general anesthesia on radical mastectomy.