Objective To evaluate the reliability and validity of Chinese version of the Carlson's Prior Conditions Instruments(CPCI)for post-operative pain management practices of nurses.Methods With convenience sampling,a total of 200 surgical nurses were investigated with Chinese version Dimensions of Carlson's Prior Conditions Instruments (CPCI),and the reliability and validity were tested.Results Six factors were extracted by factor analysis and could explain 61.089％ of the total variance with the Chinese version of CPCI.The correlation between each sub-scale and total scale were ranged from 0.583～0.825.The Cronbach's α、split-half coefficient and test-retest reliability of PICI were 0.865、0.661、0.904 respectively.The Cronbach's α、split-half coefficient and test-retest reliability of each sub-scale were ranged from 0.772～0.860、0.678～0.830、0.822～0.946 respectively.Conclusions The revised Chinese CPCI is reliable and valid,and can be used in the research of prior conditions which may influence surgical nurses to take evidence-based pain management practices.

OBJECTIVE:To establish the ultraviolet visible spectrophotometry(UV-VIS)for the determination of Fe content in iron dextran preparations.METHODS:Under the acidic condition,Fe~(3+)was dissociated from iron dextran solution by heating,then Fe~(3+)was deoxidized into Fe~(2+)by hydroxylamine hydrochloride,and red Fe~(2+)-orthophenanthroline complex was formed through combination with o-phenanthroline.The content of the Fe~(2+)-orthophenanthroline complex was determined by UV-VIS at a wavelength of 510 nm.RESULTS:The linear range of Fe~(2+)was 0.5～4.0?g?mL~(-1)(r=0.999 9). The average recoveries of two preparations(tablets and injection)of iron dextran were 99.8%(RSD=0.52%)and 99.7% (RSD=0.44%),respectively.CONCLUSION:The UV-VIS method is simple,accurate in results and applicable for the determination of iron dextran preparations.

Objective To evaluate the efficacy and safety of bortezomib combined with dexamethasone and thalidomide in the treatment of autologous stem cell transplantation ( ASCT) in multiple myeloma ( MM) . Methods The randomized con-trolled trials ( RCTs) on combined therapy with bortezomib,dexamethasone and thalidomide for ASCT in MM were retrieved from Pubmed,Medline,the Cochrane Library,CNKI,VIP and Wanfang databases (published until December 2014).The method of the Cochrane systematic review was used to evaluate the quality of the included RCTs and the Review Manager 5.3.5 software was em-ployed for Meta-analysis. Results Five RCTs involving 1 271 patients were included.The meta analysis results showed that the complete remission ( CR) rate,near-CR rate and total effective rate were significantly higher after combined treatment with borte-zomib,dexamethasone and thalidomide when compared with those in other combination therapies [CR+nCR, RR=1.50,95%CI (1.16,1.94),P=0.002;the total effective rate,RR=1.13,95%CI (1.03,1.24),P=0.009].In terms of safety,the grade 3/4 ad-verse events were significantly increased in the group of combined therapy with bortezomib,dexamethasone and thalidomide [ RR=1.29,95%CI (1.05,1.59),P=0.02]. Conclusion Bortezomib combined with thalidomide and dexamethasone for the treat-ment of ASCT in MM can significantly improve the CR+nCR and the total effective rate,but it also increases the incidence of the overall adverse events at the same time.

Objective To evaluate the effects of dexmedetomidine on inflammatory responses in lung tissues during one-lung ventilation (OLV) in patients undergoing esophageal cancer resection.Methods Forty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients,aged 25-65 yr,with body mass index of 18-25 kg/m2,scheduled for elective radical resection of esophageal cancer,were divided into 2 groups (n=20 each) using a random number table:dexmedetomidine group (group D) and control group (group C).Dexmedetomidine was infused intravenously in a loading dose of 0.6 μg/kg over 10 min before induction of anesthesia,followed by an infusion of 0.4 μg · kg-1 · h-1 until 30 min before the end of operation in group D,and the equal volume of normal saline was given instead in group C.After intubation (T1),at 30,60 and 90 min of OLV (T2-4),and at 30 min after restoration of two-lung ventilation (T5),blood samples were taken from the internal jugular vein.Broncho-alveolar lavage fluid (BALF)in ventilated lung was collected at T1-4.The concentrations of tumor necrosis factor-alpha (TNF-α),interleukin-6 (IL) and IL-10 in plasma and BALF were determined by enzyme-linked immunosorbent assay.Results Compared with group C,the plasma concentrations of TNF-α at T5 and IL-6 at T4,5 were significantly decreased,the plasma concentration of IL-10 was increased at T4,5,and the concentration of TNF-α in BALF at T4 and concentration of IL-6 in BALF at T3,4 were decreased,and the concentration of IL-10 in BALF was increased at T4 in group D (P＜0.05).Conclusion Dexmedetomidine can significantly ameliorate the inflammatory responses in lung tissues during OLV,thus reducing systemic inflammatory responses in patients undergoing esophageal cancer resection.

Objective The questionaires of the ONFH aegers who were hospitalized in Kanggu hospital,during 2005-2008 ,were collect-ed to evaluate the therapeutic effects of acupotomy by proper statistical methods. Methods Four indexes according to the criteria of Therapeutic effect of adult ONFH recovery and reconstruction (ZHAO Dewei, 1996) were measured to evaluate the effect of the treatment. Results Monofac-torial analysis showed that the treatrnent was effective,but some phenomena could not be correctly explined in specialized field. This problem was re-solved appropriately by structural equation model(SEM). Conclusion By the method of SEM, the confounding factors could be better controlled and the evaluation was more reliable.

ObjectiveTo evaluate the reliability and validity of Chinese version of Postoperative Pain Assessment Nursing Practice Questionnaire (PPA-NPQ).MethodsA forward-backward translation procedure was followed to develop the Chinese version of PPA-NPQ.A total of 258 surgical nurses were investigated by the revised Chinese version dimensions of PPA-NPQ,then the results were tested on reliability and validity by SPSS17.0.ResultsThe cronbach's α of the Chinese version of PPA-NPQ was 0.889.The split- half coefficient and testretest reliability of PPA-NPQ were 0.729,0.875 respectively ; the Cronbach's a,split- half coefficient and test-retest reliability of each sub-scale were ranged from 0.820-0.857,0.797-0.862,0.846-0.902 respectively.The correlation between each sub-scale and total scale were ranged from 0.704-0.818 (P ＜ 0.01 ).ConclusionThe revised Chinese PPA-NPQ is reliable and valid,and can be used to test the level of postoperative pain assessment practice by surgical nurse.

Aiming at the confused situation of Stephania tetrandra and its adulterants in the production,supply and sale market,the author had overviewed information on Stephania tetrandra and its adulterants in source,character identification,microscopic identification,physical and chemical identification at home and abroad in recent years,so thus for scientific identify of species,distinguishing between the families and genera and correcting medication for clinical use.

The severity of ischemic brain injury was closely associated with the mortality and disability of stroke. How to limit ischemic brain injm-y to the greatest extent and promote the recovery of neurological function is one of the most concerned hotspots at present in the field of neuroscience. A large number of studies have shown that a variety of factors involve in the pathological process of ischemic brain injury, in which, the role of T lymphocyte-mediated immune inflammatory response in ischemic brain injury has received increasing attention. This article mainly reviews the role of T cells in ischemic brain injury.

OBJECTIVE:To try to establish a combined serum-pharmacology and electrophysiology method for the study of mechanism of chuanxiong extract in dilatating coronary artery.METHODS:Chuanxiong extract was intragastrically given to rats and mice,then the serum contents of tetramethylpyrazine(TMP)were determined by HPLC,which provided data for electrophysiological study.The action of chuanxiong extract on Ca 2+ -activated K channel(Kca)of smooth muscle of coronary artery in pigs was studied by patch clamp technique.RESULTS:The calibration curve of TMP was linear in the range of0.216～54?g/ml(r=0.9999).The recovery was100.7%～102.4%.The serum concentrations of TMP in rats and mice were(3.56?3.01)and(8.19?6.57)?g/ml respectively.The chuanxiong extract could not markedly activate the Kca of smooth muscle of coronary artery in patch clamp study.CONCLUSION:The established method for TMP determination is feasible and relieable.In order to improve the combined electrophysiology and serum pharmacology technique,high quality medical materials should be adopted and the bioavailability improved.

OBJECTIVE:To analyze the clinical application and trend of psychotherapeutic agents in our hospital.METH-ODS:The application of psychotherapeutic agents in our hospital from 2004 to 2006 was analyzed statistically in respect of drug varieties,consumption sum,DDDs and defined daily cost etc.RESULTS:The consumption sum of antipsychotic agents showed a year-on-year upward trend over the 3 year(379,100 yuan,438,800 yuan and 694,100 yuan,respectively).However,the consumption sum of antidepressants showed a downward trend over the 3 years(444,800yuan,440,200yuan,and 335,800 yuan,respectively).The total consumption of the two(antipsychotic agents and antidepressants) made up over 90% in the total psych-otherapeutic agents.CONCLUSION:Of the total consumption sum of psychotherapeutic agents,antipsychotic agents and antidepressants have made their way into the lead,of which,paroxetine,risperidone and olanzapine showing highest percentages.