Objective To explore the influence of cirrhotic portal hypertension and its complications on liver transplantation. Methods The literatures of the recent years on influence of hepatic cirrhotic portal hypertension on liver transplantation were reviewed. Results Splenomegaly, hypersplenism, portal vein thrombosis, portosystemic shunt and collateral flow in cirrhotic patients will increase the difficulty of liver transplantation and lead to more postoperative complications. Appropriate handling of these conditions can achieve a higher success rate of liver transplantation. Conclusion Correct management of end-stage cirrhotic portal hypertension and its complications can expand the indications of liver transplantation and improve long-term survival rates.

Carcinoma, Hepatocellular ; therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms ; therapy

Carcinoma, Hepatocellular ; therapy ; Drug Delivery Systems ; methods ; trends ; Genetic Therapy ; Humans ; Liver Neoplasms ; therapy ; Receptor, Epidermal Growth Factor ; administration & dosage

Antineoplastic Agents ; therapeutic use ; Carcinoma, Hepatocellular ; pathology ; surgery ; therapy ; Catheter Ablation ; methods ; Chemoembolization, Therapeutic ; Combined Modality Therapy ; Hepatectomy ; methods ; Hepatic Artery ; Humans ; Lung Neoplasms ; pathology ; surgery ; therapy ; Neoplasm Staging ; Radiotherapy, Conformal

Objective To observe the effect of asarone injection on terms of airway inflammation factor in asthmatic children.(Metho)ds Sixty asthmatic children were chosen and divided randomly into methotrexate group and control group.In the methotrexate group,intravenous injection with 2 times per day was given.The concentration of the injection solution was 0.01%,which was mixed by(0.5 mg/kg) asarone injection and 10% glucose injection.In control group,intravenous injection once per day was given.The solution consisted of 4-6 mg/kg aminophyline injection and 100 mL 5% glucose injection.Every 7 continuous days was taken as one process stage.Two process stages were observed during the experiments.Results After two weeks,the eosinophils and the macrophage were changed significantly(P

Carcinoma, Hepatocellular ; therapy ; Humans ; Liver Neoplasms ; therapy

Combined Modality Therapy ; Humans ; Liver Neoplasms ; therapy

Objective: To study the protective effects of electroacupuncture of Zusanli acupuncture on rat hepatic ischemia/reperfusion injury and the possible mechanism. Methods: Forty male SD rats were randomly divided into 4 groups (each group n=10) : sham(A) , ischemia/reperfusion(B), ischemia/reperfusion+ non-electroacupunture(C), and ischemia/ reperfusion + electroacupuncture of Zusanli acupuncture point(D). Animals in C and D groups received electroacupuncture of Zusanli acupuncture point (4 mA, 2/100 Hz) before ischemia for 45 min. Hepatic ischemia/reperfusion injury (70%) was induced by blocking blood inflow of the left transverse lobe and middle lobe for 90 min, then reperfusion was allowed for 8 h; blood samples were obtained from the inferior vena cava for determination of serum ALT. Meanwhile, real-time PCR was used to examine the heptaic expression of TNF-α and IL-10. Results: B, C, and D groups demonstrated significantly higher levels of serum ALT and hepatic TNF-α and IL-10 compared with A group(P<0.05), and the increase of ALT and TNF-α in D group was significantly lower than those in B and C group (P<0.05). Expression of IL-10 was not significantly different between the 3 groups (P>0.05). Conclusion: Electroacupuncture of Zusanli acupuncture point can effectively protect against hepatic ischemia/reperfusion injury, which is possibly related to the cholinergic anti-inflammatory pathway.

Objective To evaluate the biocompatibility,immunology and physiologic features of encapsulated Newborn Porcine Islets(NPI) in the liver of the recipient dogs with type I diabetes.Methods Type I diabetic dogs were perfused with 400 000-600 000 encapsulated NPI(group A,n = 15)or unencapsulated NPI(group B,n = 15)through the hepatic artery without immunosuppressive treatment.Liver function and CD4/CD8 in the recipients were measured before and after the transplantation.The livers from all NPI recipient dogs were analyzed by histopathology 6 months after transplantation(Tx).Results Insulin dose administrated to group A was reduced gradually within one week after Tx,from 22 u before Tx to 5 u after Tx,exogenous insulin required for group B was decreased from 24 u to 10 u.However,2 to 3 weeks after Tx,the insulin dose given to group B returned to the original level before Tx.In contrast,the amount of insulin administrated to group A was continually reduced to 8 u.Moreover,CD4+ cells in the blood of group B recipients were higher than that before Tx,whereas no significant alteration of CD4+ cells and CD8+ cells in the blood of group A after Tx.All NPI recipient dogs demonstrated a normal function and structure of the liver after Tx.Conclusion Microcapsulated NPI has a good biocompatibility in recipients livers providing prolong-ation of xenograft survival,and correcting the hyperglycemia of diabetic canines.(J Intervent Radiol,2006,15: 607-610)

Objective To study the chemical constituents from Vernonia chunii of Hainan Province.Methods The constituents were isolated and purified by repeated column chromatography.Their structures were identified on the basis of physiochemical properties and spectral data.Results Four compounds were isolated and identified as:lupenyl propionate(Ⅰ),lupenyl(Ⅱ),oleanolic acid(Ⅲ),and daucosterol(Ⅳ).Conclusion Compound Ⅰ is a new compound,the others are isolated from this plant for the first time.