1.The Efficacy of Flavonoid Antioxidant from Chocolate Bean Extract: Prevention of Myocyte Damage Caused by Reperfusion Injury in Predominantly Anaerobic Sports
HN Rasyid ; YD Ismiarto ; R Prasetia
Malaysian Orthopaedic Journal 2012;6(2):3-6
Background: Use of predominantly anaerobic energy
systems such as that seen in 800-meter athlete runners
disrupts mitochondrial function as an energy source.
Furthermore, it produces free radical substances and causes
myocyte damage. Malondialdehyde (MDA) plasma
concentrations correlate with free radical levels and are
therefore predictive of cell damage. Objective: To analyse
the effect of flavonoid antioxidant from chocolate bean
extract for prevention of lipid peroxidation of myocyte
membranes caused by free radical substances in athletes
partaking in predominantly anaerobic sports. Materials and
Methods: The study of population consisted of 16 junior
athletes who compete in 800-meter races. This was a
randomized experimental study. Subjects were divided into
two groups, chocolate bean extracts and placebo groups, and
then practiced regularly for 14 days. All subjects were
assessed on day 15. Results were analysed statistically using paired t test, ANOVA and Duncan tests. Results:
Concentrations of MDA were reduced in flavonoid group.
Conclusion: Flavonoid antioxidant from chocolate bean
extract may prevent myocyte damage was caused by
reperfusion injury.
2.Comparison of Interobserver Reliability between Junior and Senior Resident in Assessment of Developmental Dysplasia of The Hip Severity using Tonnis andI nternational Hip Dysplasia Institute Radiological Classification
Ismiarto YD ; Agradi P ; Helmi ZN
Malaysian Orthopaedic Journal 2019;13(3):60-65
Introduction: The radiographic classification for developmental dysplasia of hip to quantify the severity of disease consist of Tonnis and International Hip Dysplasia Institute (IHDI) classification. The Ossification center of the femoral head in DDH patient more than six months is still vague or eccentric, so the reliability of both classifications is still in question and especially is influenced by the experience of the observer. This study aims to test and compare interobserver reliability in evaluation of DDH patients using IHDI and Tonnis classification assessed by senior and junior orthopaedic residents which had different degree of experience. Materials and Methods: This study used retrospective analysis of pelvic supine AP view radiograph of DDH patients from 2014 to 2017. All three observer groups analysed the pelvis radiographs using Tonnis and IHDI classification. Inter and intra-observer reliability was measured by Cohen’s and Fleiss Kappa method, respectively. Results:The Fleiss Kappa value for 15 radiographs of DDH patients assessed by senior residents using Tonnis and IHDI classification are 0.715 and 0.832 and result of Fleiss Kappa value assessed by junior residents are 0.577 and 0.845, respectively. Intra-observer reliability for Tonnis classification was lower in junior group compared to other two groups but showed almost perfect value in all groups for IHDI classification. Conclusion: Significantly different results were noted between junior and senior residents in assessing DDH severity, with higher diagnostic reliability in senior residents compared to junior residents. In general, junior resident has less clinical experiences in many aspects in comparison with the seniors.