OBJECTIVE:To investigate the features of adverse drug reactions(ADR) occurred in the infusion room of our hospital so as to improve rational clinical drug use.METHODS:A total of 225 ADR cases reported by the infusion room of our hospital from Jan.1,2007 to Dec.31,2008 were analyzed retrospectively and statistically.RESULTS:Of the total 225 ADR cases reported,109 cases(48.44%) were children aged below 10;115 cases(51.11%) occurred within 10～30 min;ADR were induced by 29 kinds of medicines,with cephalosporin and penicillins showing the highest proportions(43.56% and 23.56%,respectively);143 cases(63.6%) manifested more often as lesions of skin and its appendage followed by ADR of digestive system(40 cases/17.8%).CONCLUSION:ADR monitoring plays an important role in medical institution.Tightening ADR monitoring in the infusion room contributes to patients' medication safety.

Objective To explore the effect of follow-up nursing intervention on preventing dental plaque during oral fixed orthodontic appliance.Methods One hundred and twenty orthodontic patients receiving oral fixed orthodontic treatment were randomly divided into control and experiment groups equally according to visit time.The control group received conventional nursing during the process and follow-up nursing intervention during the process.The two groups were compared in terms of dental plaques before orthodontic, 3 and 6 months after the orthodontic treatment.Results Before the treatment, there was no significant differences in the dental plaques between them(P>0.05), but the indices of dental plagues in the experimental group were significantly lower than those of the control group 3 and 6 months after the orthodontic appliance(P<0.001).Conclusion Follow-up nursing care during orthodontic appliance are more effective for keeping oral hygiene.

Objective:To observe the efficacy of calcined bovine bone(CBB)in the repair of animal bone defects.Methods:Ca-nine alveolar bone defect model,rat and rabbit calvarial critical size defect models were established respectively.All animals were randomly divided into 2 groups(n=6).The defects in the experimental group were repaire with CBB,those in the control group were not treated.The effects were observed by HE staining,Micro CT and Masson trichrome staining.Results:Canin alveolar bone de-fects were well repaired 8 week after operation.The skull defects in rabbits and SD rats were replaced by new bone 1 2 and 8 weeks after operation respectively.In all the control groups bone defects were not healed or not completely repaired.Conclusion:CBB is ef-fective in the repair of bone defects.

Objective:To assess the efficacy of immunosuppressor on treatment of Henoch-Sch?nlein purpura nephritis(HSPN).Methods:Literatures were searched in PubMed, Cochrane library, Web of Science, Wanfang database, CNKI and CBM database from inception to January 2021.The studies that investigated the effect of immunosuppressor on HSPN outcomes were included.Article screening, data extraction and quality assessment were accomplished by two investigators independently, and statistical analyses were performed by STATA 14.Results:Ten studies were included with 443 cases, of which, 245 cases were in the experimental group while 198 cases were in the control group.The Meta-analysis showed that the experimental group had higher complete remission rate( OR=1.95, 95% CI 1.19-3.22, P=0.009), total remission rate ( OR=2.92, 95% CI 1.74-4.88, P<0.001), proteinuria decreasing level ( SMD=0.35, 95% CI 0.09-0.61, P=0.008), the increasing level of serum albumin ( SMD=1.27, 95% CI 0.43-2.11, P=0.003) and the increasing level of estimated glomerular filtration rate ( SMD=0.48, 95% CI 0.21-0.76, P=0.001), lower relapse rate ( OR=0.19, 95% CI 0.05-0.72, P=0.015) as well as death rate ( OR=0.19, 95% CI 0.04-0.78, P=0.021)than those of the control group. Conclusion:The immunosuppressor could enhance complete remission rate, total remission rate, proteinuria decreasing level, the increasing level of serum albumin and the increasing level of estimated glomerular filtration rate, reduce relapse rate and death rate of HSPN patients.

Objective: To explore the influence of different cement spaces on the marginal adaptation of CAD/CAM zirconia inlay. Methods: 30 teeth extracted for orthodontic purpose were selected and divided into 3 groups (Group A 10 μm, Group B 30 μm, Group C 50 μm). The marginal spaces of inlays were recorded by the light-body Silicone impression material, and measured by microscope. The data were analyzed by SPSS 13.0. Results : All the inlays fitted very well and all the marginal spaces were less than 120 μm. The shoulder of Group A was statistically lower than Group B and Group C (P < 0.05). The axial surface of Group B was statistically lower than Group C (P < 0.05). Conclusions CEREC zirconia inlay is satisfactory when the cement space is between 10-50 μm.

Ultrasound has become one of the most important imaging modalities for prenatal screening because of its advan-tages of not requiring irradiation and easy operation,and it is widely used throughout pregnancy.With the rapid development of artificial intelligence,ultrasound image recognition based on deep learning has been researched extensively in the application of prenatal screening and has shown significant advantages in the detection of fetal cranial and cardiac structures and fetal anoma-lies.This technology can improve the efficiency of prenatal ultrasound screening,increase the detection rate of fetal anomalies,optimize the quality of healthcare services,and improve patient professionalism and patient satisfaction.Moreover,it plays a cru-cial role in improving healthcare access in rural and low-income areas,supporting existing clinical practices,and streamlining workflow processes.

Objective To explore the application effect of healthcare failure mode and effect a-nalysis(HFMEA)in nursing risk management of emergency surgery for patients with traumatic brain injury(TBI).Methods Taking the HFMEA model as the theoretical framework,the emergency sur-gical process of TBI was analyzed,a flow chart was drawn,and the potential risk factors were ana-lyzed.Corresponding intervention programs were adopted for high-risk failure modes,and 80 patients from November 2022 to April 2023 were conducted with routine management before implementation of HFMEA(control group),the other 80 patients from May to October 2023 were conducted with man-agement after implementation of HFMEA(observation group).The surgical efficiency(preoperative waiting time,surgical preparation time,anesthesia induction time,postoperative handover time),the incidence rates of adverse events in the operation room(incomplete preparation of supplies,contami-nation of surgical drapes,insufficient or defective intraoperative instruments,errors in writing nursing records,incorrect or missing items in handover information),the incidence rates of perioperative com-plications(low intraoperative body temperature,pressure injury,abnormal fluctuations in vital signs during surgery,wound infection,lung infection)and satisfaction degree of surgical doctors to nurses for current operations(itinerant nurses,instrument nurses)were compared between two groups.Re-sults The observation group had significantly shorter preoperative waiting time,surgical preparation time,anesthesia induction time,and postoperative handover time compared to the control group(P＜0.01).The incidence rate of adverse events in the operation room for the observation group was 16.25％,which was significantly lower than 46.25％of the control group(P＜0.01).The inci-dence rate of complications was 8.75％in the observation group,which was significantly lower than 26.25％in the control group(P＜0.01).Satisfaction degree of the doctors to nurses for the current operation in the observation group was significantly higher than that in the control group(P＜0.05).Conclusion Application of the HFMEA model in the perioperative nursing management of patients with emergency surgery for TBI can effectively improve surgical efficiency,reduce the inci-dence rates of nursing-related adverse events and complications,and enhance satisfaction degree of doctors to nurses in operation room.

Objective To investigate the impact of a peer support model on the mental health of caregivers and the perceived social support and psychiatric symptoms of the mental disorder patients under their care.Methods Patients with mental disorders undergoing long-term community-based rehabilitation and their primary caregivers were recruited for this study.A total of 44 pairs of eligible patients and caregivers were selected based on a 1∶1 matching ratio.Systematic peer support activi-ties were conducted exclusively for the caregivers.The General Health Questionnaire(GHQ)and the Symptom Checklist-90(SCL-90)were administered before and after the intervention to assess the mental health status of caregivers.The Perceived Social Support Scale(PSSS)and the Brief Psychiat-ric Rating Scale(BPRS)were employed to evaluate the patients'perceived social support and psychi-atric conditions before and after the intervention.Results A total of 44 valid questionnaires from car-egivers and 42 from patients were collected.The GHQ score and the total scores,the number of positive item,positive total scores,and positive mean scores of and SCL-90 of caregivers were significantly low-er after the intervention compared to pre-intervention(P＜0.05 or P＜0.001).For patients,the fami-ly support score,extracurricular support score,and total score of the PSSS were significantly higher post-intervention compared to pre-intervention(P＜0.05 or P＜0.001).Compared to pre-intervention,patients'scores on anxiety and depression,lack of energy,thought disturbance,activation,hostility and suspicion,and the total score on the BPRS were significantly lower after the caregiver peer sup-port intervention(P＜0.001).Conclusion The peer support model contributes to improving the mental health of caregivers for patients with mental disorders and enhancing the patients'psychiatric conditions.

Objective To explore the application effect of healthcare failure mode and effect a-nalysis(HFMEA)in nursing risk management of emergency surgery for patients with traumatic brain injury(TBI).Methods Taking the HFMEA model as the theoretical framework,the emergency sur-gical process of TBI was analyzed,a flow chart was drawn,and the potential risk factors were ana-lyzed.Corresponding intervention programs were adopted for high-risk failure modes,and 80 patients from November 2022 to April 2023 were conducted with routine management before implementation of HFMEA(control group),the other 80 patients from May to October 2023 were conducted with man-agement after implementation of HFMEA(observation group).The surgical efficiency(preoperative waiting time,surgical preparation time,anesthesia induction time,postoperative handover time),the incidence rates of adverse events in the operation room(incomplete preparation of supplies,contami-nation of surgical drapes,insufficient or defective intraoperative instruments,errors in writing nursing records,incorrect or missing items in handover information),the incidence rates of perioperative com-plications(low intraoperative body temperature,pressure injury,abnormal fluctuations in vital signs during surgery,wound infection,lung infection)and satisfaction degree of surgical doctors to nurses for current operations(itinerant nurses,instrument nurses)were compared between two groups.Re-sults The observation group had significantly shorter preoperative waiting time,surgical preparation time,anesthesia induction time,and postoperative handover time compared to the control group(P＜0.01).The incidence rate of adverse events in the operation room for the observation group was 16.25％,which was significantly lower than 46.25％of the control group(P＜0.01).The inci-dence rate of complications was 8.75％in the observation group,which was significantly lower than 26.25％in the control group(P＜0.01).Satisfaction degree of the doctors to nurses for the current operation in the observation group was significantly higher than that in the control group(P＜0.05).Conclusion Application of the HFMEA model in the perioperative nursing management of patients with emergency surgery for TBI can effectively improve surgical efficiency,reduce the inci-dence rates of nursing-related adverse events and complications,and enhance satisfaction degree of doctors to nurses in operation room.

Objective To investigate the impact of a peer support model on the mental health of caregivers and the perceived social support and psychiatric symptoms of the mental disorder patients under their care.Methods Patients with mental disorders undergoing long-term community-based rehabilitation and their primary caregivers were recruited for this study.A total of 44 pairs of eligible patients and caregivers were selected based on a 1∶1 matching ratio.Systematic peer support activi-ties were conducted exclusively for the caregivers.The General Health Questionnaire(GHQ)and the Symptom Checklist-90(SCL-90)were administered before and after the intervention to assess the mental health status of caregivers.The Perceived Social Support Scale(PSSS)and the Brief Psychiat-ric Rating Scale(BPRS)were employed to evaluate the patients'perceived social support and psychi-atric conditions before and after the intervention.Results A total of 44 valid questionnaires from car-egivers and 42 from patients were collected.The GHQ score and the total scores,the number of positive item,positive total scores,and positive mean scores of and SCL-90 of caregivers were significantly low-er after the intervention compared to pre-intervention(P＜0.05 or P＜0.001).For patients,the fami-ly support score,extracurricular support score,and total score of the PSSS were significantly higher post-intervention compared to pre-intervention(P＜0.05 or P＜0.001).Compared to pre-intervention,patients'scores on anxiety and depression,lack of energy,thought disturbance,activation,hostility and suspicion,and the total score on the BPRS were significantly lower after the caregiver peer sup-port intervention(P＜0.001).Conclusion The peer support model contributes to improving the mental health of caregivers for patients with mental disorders and enhancing the patients'psychiatric conditions.