The management of extremely low birth weigh infants is challenging,including how to communicate with family members,cooperation between pediatric and obstetrics,overall NICU management level,targeted and personalized management mode,and etc.In this article,clinical management experience for extremely low birth weigh infants was summarized,such as management at birth,stabilization of body temperature after birth,prevention and treatment of intracranial hemorrhage,infection,and blood transfusion management,as well post-discharge management.

Objective To analyze the curative effect and safety of the estrogen as an adjunctive treatment of senile vaginitis.Methods 100 patients with senile vaginitis in our hospital from June 2011 to September 2012 were divided into observation group (n =50) and control group (n =50).Observation group was given estrogen plus metronidazole and control group was given metronidazole only.Results 45 cases were cured and 4 cases had effective treatment in observation group,and 21 cases were cured and 17 cases had effective treatment in control group.The efficacy rate was 98.0％ (49 cases)in observation group versus 76.0％(38 cases) in control group (x2=11.50,P＜0.01).After the treatment,the recurrence rate was 6.1％ (3 cases)and 26.3 ％ (10 cases)in observation and control groups respectively (x2 =10.66,P＜0.05).After treatment,vaginal health scores,symptom scores of vaginitis,and vaginal PH were significantly higher in the observation group than in the control group (all P＜0.05).In addition,the improvements of signs and symptoms were significantly better in the observation group than in the control group (all P＜0.05).However,there was no significant difference in adverse reaction rate between the two groups (P＞ 0.05).Conclusions Estrogen as an adjunctive treatment of senile vaginitis has better curative effect and safety.It is worthy of generalization in clinical medicine.

The pathogenesis of viral myocarditis is still not fully understood so far.However,the viral damage to the myocardial cells directly and immune-mediated injury of the myocardium have been a consensus.In recent years,the genetic susceptibility in the pathogenesis of viral myocarditis has attracted more and more attention.This review summarizes the research progress of the genetic susceptibility at home and abroad.

Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.

Fragile X syndrome is a common cause of inherit mental retardation,GABAA receptors are the major inhibitory neurotransmitter receptros in the mammalian central nervous system, implicated in anxiety,depression, epilepsy, sleeping problem, learning and memory, and so on. Several researches indicated that the GABAergic system, in particular the GABAA receptors might be related to the phenotype of fragile X syndrome. An altered expression of certain subunits of the GABAA receptors may cause the neurological and behavioural changes of the fragile X syndrome. Therefore,the GABAA receptors can be a novel therapeutic target for treatment of fragile X syndrome.

Kawasaki disease (KD) is an acute systemic vasculitis and its main life-threatening complications are coronary artery lesions(CAL), including coronary artery stenosis, thrombosis, aneurysm rupture, or sudden death. KD has now surpassed acute rheumatic fever as the leading cause of acquired heart disease in children. Therefore, it is important to identify as early as possible KD patients who are at risk for the development of CAL and intervent them timely. Genetic factors are thought to have important influences on the development and progress of Kawasaki disease and its CAL. In previous reports, several genetic polymorphisms, such as VEGF, MMPs and CD14 gene, were associated with the development of CAL. This review will introduce the study of gene polymorphisms in susceptibility to CAL in children with KD recently.

Objective To assess the medical staff and department from the aspects of basic workload,quality,science & research,education and so on.Methods Some data on the above aspects were extracted from HIS,and some were input manually.Results Some report forms were established on the basis of the above data.Conclusion An assessment platform for medical quality and achievement is constructed.

Objective To analyze the causes of falls in 107 patients, and to provide reference for the pre-vention of falls in hospitalized patients .Methods The analysis of hospitalized patients fall down where nursing area , age, fall time, place, disease, carer and the extent of internal medicine , brain and geriatrics is high incidence area of falls in the hospital , the ratio was 75.70%in total;the age of the fall patient ≥60 years old accounted for 81.31%;The high time for fall in the night (47.66%);Ward was the main falls area;Occurrence fall disease of fall patients mainly with cerebral infarction , hypertension, coronary heart disease , diabetes, accounted for 47.67%; In the fall with carer accounted for 71.96%;First grade damage accounted for 49.35%.Conclusion elderly people are the high risk group of falls , and the decline of physiological function and the influence of many diseases and drugs have a close relationship with fall .High time and place of falls in patients hospitalized in the night and ward , fall damage is given priority in mild and no damage , in fall patient with carer rate is higher .So the future hospital with fall preven-tion key points of nursing work should focus on pay close attention to the patient 's physiological status , disease and drug use, strengthen medical personnel to fall early risk assessment and give corresponding intervention measures , pay attention to the ward environment and the safety of facilities , strengthen the nursing management and nursing edu-cation, so as to reduce the occurrence of the event of a fall .

Objective: To introduce the advantages of approximate entropy (ApEn) in analyzing biological signals, to discuss the influences of time series' parameters on ApEn and elaborate the present conditions and prospects of its application on medicine. Methods: According to the definition and algorithm, ApEn has advantages on estimating the complexity of signal comparing with other non-linear analysis methods such as correlation dimension, fractal dimension, lyapunov index etc. Based on ApEn algorithm, we formulate programme to quantificationlly analyze the relationship between ApEn and each parameter of time series; Human EEG and ECG and other biological signals can reflect the state of the body. Through detecting changes of biological signals'ApEn, we can detect and monitor the state of an organization. Results: ApEn has many advantages such as a good anti-noise ability, the short date and so on. It makes up the defects of the correlation dimension ect. ApEn has nothing with the amplitude of time series. In the range of low-frequency, ApEn almost increases with frequency. When the date length is more than 1000 points, ApEn is stable. It quantificationlly describes that ApEn only requires short date. Recently. ApEn is widely used in diagnostics, monitoring, anesthesiology, and achieves good results. Conclusion: ApEn is a new developed non-linear analysis method which can estimate the complexity of the signal quantificationlly. It provides a new approach for diagnosing and monitoring a number of diseases. It has a wide application prospect.

Objective A survey was conducted to explore the relationship between research capacity and clinical practice in local public hospitals.Methods A third grade class A hospital from Yangzhou city was selected as an example;and 357 medical staff were surveyed through a designed questionnaires.Results Data collected by questionnaires was analyzed to understand the relationship between research ability and clinical practice as well as the awareness of the hospital staff.The results showed that the hospital staff realized that such relationship should be positively associated with each other, and mutual penetration.Conclusions Recommendations have been raised to promote research ability, and then enhance the quality of clinical practice.