1.Advance of the relationship between Th17 and autoimmune diseases
International Journal of Pediatrics 2011;38(3):298-300
Th17 is a CD4+ T cell subset that is a new member of Th1 and tH2.Recent studies have shown that it products IL-17A,IL-17F,IL-21 and IL-22,which play an imoortant role in rheumatoid arthritis.systemic lupus erythematosus,systemic sclerosis,inflammatory howel disease.autoimmune myocarditis and other autoimmune diseases.Deepen the understanding of Th17 and Th17 production in the advancement of autoimmune diseases will provide a new basis for future diagnosis.Th17 will become a new target for the treatment of human autoimmune diseases.
2.The research of curative effect of hysteroscope electrotomy for treating infertile women with uterine septum
China Medical Equipment 2017;14(9):103-106
Objective:To study the effect of hysteroscope electrotomy for treating infertile women with uterine septum.Methods: 64 patients with uterine septum were divided into observation group (25cases) and control group (39cases) according to different operation method. Patients of observation group received the combination mode of hysteroscope and laparoscope while the patients of control group received hysteroscope electrotomy. And thenthe effects of the two surgical methods for pregnancy outcome of the patients of the two groups were compared. Results: In 22 patients with complete uterine septum, the postoperative pregnancy rate was 59.09% which was significantly higher than preoperative pregnancy rate (18.18%) (x2=4.539,P<0.05). The postoperative rate of normal childbirth in term was 31.82% which was significantly higher than preoperative outcome (0%) (x2=8.324, P<0.004). In 42 patients which incomplete uterine septum, the postoperative pregnancy rate was 73.81% which was significantly higher than preoperative pregnancy rate (33.33%) (x2=13,832,P<0.05). The postoperative rate of normal childbirth in term was 54.76% which was significantly higher than preoperative outcome (0%)(x2=31.672, P<0.004).Conclusion: Hysteroscope electrotomy is significant in the treatment for patient with uterine septum, and it has series of advantages of minimally invasive surgery including small wound, less blooding, fast prognosis and others. Therefore, it is worthy in the clinical promoting.
3.Design and Application of Hospital Assessment Information Management System
Chinese Medical Equipment Journal 1993;0(06):-
Objective To assess the medical staff and department from the aspects of basic workload,quality,science & research,education and so on.Methods Some data on the above aspects were extracted from HIS,and some were input manually.Results Some report forms were established on the basis of the above data.Conclusion An assessment platform for medical quality and achievement is constructed.
4.The Current Development of Stem Cell Research from Major Countries in the World
China Biotechnology 2006;0(06):-
Introduced policy support and research outputs and market demand of stem cell in the major countries.Research papers and Patent of stem cell have been analyzed by SCI-EXPANDED Database and Derwent databases in 1995~2008,so as to provide a useful reference for China.
5.An Amendment on Information Extraction of Biolog EcoPlate~(TM)
Microbiology 2008;0(07):-
Biolog EcoPlateTM is a mainstream approach of studying community-level physiological profiles of microbes. To correct misunderstanding and insufficiency of experimental result explanation, we announced an amendment of information extraction of Biolog EcoPlateTM, which included two parts: (1) carbon substrates assortment sheets based on microbial physiological metabolism and ecological function, providing referrence and index for researchers; (2) illustration of how to use assorment sheet and ordination method to find out more information, guiding by environmental concentration principle.
6.Survey on the Relationship between Scientific Research and Medical Treatment in Public Hospitals——Using a Hospital in Yangzhou as an Example
Chinese Journal of Medical Science Research Management 2016;29(2):-
Objective A survey was conducted to explore the relationship between research capacity and clinical practice in local public hospitals.Methods A third grade class A hospital from Yangzhou city was selected as an example;and 357 medical staff were surveyed through a designed questionnaires.Results Data collected by questionnaires was analyzed to understand the relationship between research ability and clinical practice as well as the awareness of the hospital staff.The results showed that the hospital staff realized that such relationship should be positively associated with each other, and mutual penetration.Conclusions Recommendations have been raised to promote research ability, and then enhance the quality of clinical practice.
7.Improving the adverse cardiovascular prognosis of type 2 diabetes
Journal of Medical Postgraduates 2001;14(1):60-64
Insulin resistance is the fundamental defect of type 2 diabetes and often leads to hyperinsulinemia, which is associated with atherosclerosis and cardiovascular events. A multidisciplinary approach involving multifaceted therapeutic strategies is necessary to reduce cardiovascular events and to improve prognosis in these patients. The purpose of this review is to outline proven and promising therapeutic strategies for improving the long-term cardiovascular prognosis of patients with type 2 diabetes.
8.Ribozymes and deoxyribozymes in targeted cancer therapy
Journal of International Oncology 2010;37(12):889-892
In recent years, with the introduction of novel vectors capable of highly efficient transduction ,ribozymes and dexyribozymes have been become an ideal approach to anticancer therapy due to their high efficiency and lack of severe adverse effects. As many high efficiency targets have been found for cancer therapy, targeted therapy using ribozymes and deoxyribozymes may have multiple effects such as induction of tumor apoptosis and inhibition of tumor growth, metastasis, and angiogenesis.
9.GABAA receptors and fragile X syndrome
International Journal of Pediatrics 2010;37(6):637-640
Fragile X syndrome is a common cause of inherit mental retardation,GABAA receptors are the major inhibitory neurotransmitter receptros in the mammalian central nervous system, implicated in anxiety,depression, epilepsy, sleeping problem, learning and memory, and so on. Several researches indicated that the GABAergic system, in particular the GABAA receptors might be related to the phenotype of fragile X syndrome. An altered expression of certain subunits of the GABAA receptors may cause the neurological and behavioural changes of the fragile X syndrome. Therefore,the GABAA receptors can be a novel therapeutic target for treatment of fragile X syndrome.
10.The genetic basis of coronary artery lesions in Kawasaki disease
International Journal of Pediatrics 2010;37(5):487-490
Kawasaki disease (KD) is an acute systemic vasculitis and its main life-threatening complications are coronary artery lesions(CAL), including coronary artery stenosis, thrombosis, aneurysm rupture, or sudden death. KD has now surpassed acute rheumatic fever as the leading cause of acquired heart disease in children. Therefore, it is important to identify as early as possible KD patients who are at risk for the development of CAL and intervent them timely. Genetic factors are thought to have important influences on the development and progress of Kawasaki disease and its CAL. In previous reports, several genetic polymorphisms, such as VEGF, MMPs and CD14 gene, were associated with the development of CAL. This review will introduce the study of gene polymorphisms in susceptibility to CAL in children with KD recently.