Ghrelin is involved in the process of feeding behavior and regulation of related energy metabolism,it also modulates the secretion of gonadotropins or transmitters concerning sex hormone releasing.It is considered as the factor connecting the HPG axis and energy metabolism.Body's nutrition has a bearing upon the process of reproductive system's onset and maturation.Adequate body weight is necessary for normal puberty onset.Obese children tend to have an earlier menarche.Ghrelin may pass on the information about nutrition to the hypothamalus in puberty onset.

In recent years, with the introduction of novel vectors capable of highly efficient transduction ,ribozymes and dexyribozymes have been become an ideal approach to anticancer therapy due to their high efficiency and lack of severe adverse effects. As many high efficiency targets have been found for cancer therapy, targeted therapy using ribozymes and deoxyribozymes may have multiple effects such as induction of tumor apoptosis and inhibition of tumor growth, metastasis, and angiogenesis.

Kawasaki disease (KD) is an acute systemic vasculitis and its main life-threatening complications are coronary artery lesions(CAL), including coronary artery stenosis, thrombosis, aneurysm rupture, or sudden death. KD has now surpassed acute rheumatic fever as the leading cause of acquired heart disease in children. Therefore, it is important to identify as early as possible KD patients who are at risk for the development of CAL and intervent them timely. Genetic factors are thought to have important influences on the development and progress of Kawasaki disease and its CAL. In previous reports, several genetic polymorphisms, such as VEGF, MMPs and CD14 gene, were associated with the development of CAL. This review will introduce the study of gene polymorphisms in susceptibility to CAL in children with KD recently.

ObjectiveTo observe the effect of amlodipine besylate combined with benazepril in treatment of old patients with primary hypertension and left ventricular hypertrophy,and analyze the safety.MethodsOne hundred and eight old patients with primary hypertension and left ventricular hypertrophy were divided into observation group(54 cases) and control group(54 cases) by random digits table.The patients in observation group were treated with amlodipine besylate combined with benazepril and the patients in control group were only treated with amlodipine besylate.The levels of blood pressure,interventricular septal thickness(IVST),left ventricular posterior wall (LVPW),left ventricular end-diastolic dimension (LVEDD) and left ventficular mass index(LVMI) before and after treatment for 6 months were measured and compared between two groups.The adverse effects after treatment were compared too.ResultsAfter treatment,the levels of 24hSBP,24hDBP,IVST,LVPW,LVEDD and LVMI were significantly decreased in both groups (P ＜ 0.05).Moreover,the levels of 24hSBP,24hDBP,IVST,LVPW,LVEDD and LVMI after treatment in observation group were significantly lower than those in control group(P ＜ 0.05).There was 1 case ( 1.9％ ) of dry cough,2 cases (3.7％) of mild ankle edema in observation group,while only 2 cases (3.7％) of mild ankle edema in control group.There was no significant difference in adverse effects between two groups (P ＞ 0.05).ConclusionsCompared with amlodipine besylate single treatment,amlodipine besylate combined with benazepril in treatment of old patients with primary hypertension and left ventricular hypertrophy can more effectively control blood pressure and reverse left ventricular hypertrophy.The adverse effects are not increased,which can be applied in clinic.

Insulin resistance is the fundamental defect of type 2 diabetes and often leads to hyperinsulinemia, which is associated with atherosclerosis and cardiovascular events. A multidisciplinary approach involving multifaceted therapeutic strategies is necessary to reduce cardiovascular events and to improve prognosis in these patients. The purpose of this review is to outline proven and promising therapeutic strategies for improving the long-term cardiovascular prognosis of patients with type 2 diabetes.

Th17 is a CD4+ T cell subset that is a new member of Th1 and tH2.Recent studies have shown that it products IL-17A,IL-17F,IL-21 and IL-22,which play an imoortant role in rheumatoid arthritis.systemic lupus erythematosus,systemic sclerosis,inflammatory howel disease.autoimmune myocarditis and other autoimmune diseases.Deepen the understanding of Th17 and Th17 production in the advancement of autoimmune diseases will provide a new basis for future diagnosis.Th17 will become a new target for the treatment of human autoimmune diseases.

emphysema(9.7%)、pneumonia(6.2%),every group has obvious difference(P

Objective Studying risk factors of carotid atherosclerosis in metabolic syndrome(MS),and the relative factors with progression of carotid atherosclerosis.Methods A total of 401 elders were included in the present study.MS was defined by the criteria of IDF(219 MS,182 NMS).All subjects were required to have blood pressure monitored.Venous blood was collected after an overnight fast.Total serum cholesterol,triglycerides,high-density lipoprotein cholesterol(HDL),low-density lipoprotein cholesterol(LDL),apolipoprotein B,lipoprotein a,high-sensitive C-reactive protein,and fasting glucose and insulin were tested;insulin sensitivity index and insulin resistant index were estimated.Uria sample was also collected to test microalbumiuria,creatine and Alb/Cr.Carotid atherosclerosis was determined by B-mode ultrasound,and number and diameter of plaques,if present,were measured to obtain an atherosclerosis score.Results The occurrence of carotid atherosclerosis was significantly higher in MS(P

Objective To investigate the role of FHIT,cyclinD1,CDK4 in NSCLC.Methods Immunochemical(S-P) was used to determined 81 cases of NSCLC.Results The postive expression rates of FHIT,cyclinD1,CDK4 were significantly different between in NSCLC and in nomal lung tisses(P

Plasma fibronectin(FN) level was measured by single radial immunod if fusion method in 58 patients with chronic Cor pulmonale during acute, remission and deterioration stages, 20 cases of chronic bronchitis, 10 cases of rheumatic heart disease, and 60 healthy people as controls.We analysed the relationship between the changes of plasma FN level and the degree of the respiratory failure, pulmonary infection and acid-base disturbance in experimental groups.The results showed that plasma FN levels of the controls, and the patients with chronic bronchitis and rheumatic heart disease were 322.4?60mg/L,263?40mg/L and 333.51 48mg/L, respectively.Plasma FN level was significantly decreased in patients with Cor pulmonale during acute stage(l46?67mg/L), gradually restored at remission stage (286?62mg/L) and markedly decreased in deterioration stage (101?39mg/L).It was ako markedly decreased in the patients with severe respiratory failure, pulmonary infection and acid-base disturbance.The authors suggest thai: placma FN may be used as a valuaole parameter to evaluate the clinical severity and prognosis of the patients with Cor pulmonale.The decrease of plasma FN level in patients with chronic Cor pulmonale may be due to its increased consumption and decreased synthesis in acute and deterioration stages.