This paper presents a development model of resource information institute from organic integration the institute of information and library.The all data of resources-information institute come from and serve for theoretical research,clinical practice,and scientific research of TCM.Comparing with usual research institute and library,the resource information institute has five dominant positions,which are subjects,scientific researches,resource,professionals and services.

EML4-ALK fusion oncogene represents a new molecular target which appears mainly in lung adenocarcinoma.EML4-ALK is detected more frequently in young non-small-cell lung cancer patients who never or light smoke.ALK inhibitors(crizotinib)for the treatment of the EML4-ALK-positive non-small cell lung cancer has a high response rate.This finding can improve the individual treatment of non-small cell lung cancer.

Leptin,a proteohormone primarily made by adipocytes,directly interacts with the hypothalamus for energy balance regulation.It plays an important role in the morbility of obesity.The soluble leptin receptor(sOb-R) is one of the leptin receptor isoforms.The examination of the sOb-R concentration is valuable because of its function in the regulation of leptin concentration.Leptin shows a great potential as a childhood obesity biomarker,and its concentration could be used in assessing the responsiveness of obese children to intervention programs.

AIM: To explore the relationship of the decrease of the catharticizing action and the conjugated anthraquinone after Radix et Rhizoma Rhei was in the process of stirred-fry-with wine by comparing the content of conjugated anthraquinone among different processing Radix et Rhizoma Rhei in the solution decocted by water and extrected by methanol. METHODS: The spectrophotometer was used to assay the content of free anthraquinone and conjugated anthraquinone of different proccssing Rudix et Rhizoma Rhei in the solution decocted by water and extracted by methanol. RESULTS: In the solution decocted by water there was little difference in free anthraquinone between the raw and the processing products, however, the conjugated anthraquinone of the precessing product was much higher than the raw. CONCLUSION: The decrease of the conjugated anthraquinone can’t fully account for the reduction of the catharticizing action of Radix et Rhizoma Rhei in the process of stirred-fry with wine. The real cause needs to be explored in many aspects.

Taking eugenics,family planning and reproductive human-assisted projects for instance,the article discusses the conflicts between modern biotechnology and the contemporary ethics.It distinguishes the concepts of life quality and that of health,and advocates that the modern medicine should conduct to be in pursuit of the high quality of life.Finally,it puts forward that we should upgrade the quality of individual's life in the circumstance of a stable and integrated communal ethics.Biotechnology may be developed immeasurably,but should be used restricted and morally.

The donors' complete autonomy and voluntariness for donation is the core of ethical acceptability of living organ transplantation.Deep in the donors' heart,the awareness of self-respect and the altruism are two contradictory tendencies both in psychology and behavior.As the existence of the tension of self-respect awareness and altruism,it becomes particularly difficult and complex for the living organ donors to make autonomous decisions.This paper analyzed the tension of self-respect awareness and altruism,discussed the emotional and ethical contradictory,and proposed some suggestions based on this,hoping to provide a good internal environment and external support for the potential donors to make reasonable free decisions and guarantee the ethics of living organ transplantation.

The application of transesophageal echocardiography (TEE) in perioperative monitoring was introduced,and its involvement in non-cardiac surgery was described.The advantages and disadvantages of TEE were analyzed when applied to cardiac and non-cardiac operations for congenital heart disease,coronary disease,vascular heart disease,aorta disease and etc.The abuse of vasoactive drug or fluid is avoided due to subjective evaluation on cardiac function and volume load.TEE facilitates the anesthetist in diagnosis and evaluation of the patient with heart diseases,and the surgeon in immediate assessment of the operation,which can be used for real-time monitoring of cardiac function and hemodynamics.

Recent researches have shown that gut microbiota play an important role in pathogenesis of immune-related disorders.Type 1 diabetes mellitus,as an autoimmune disease,has received increasing attention,especially in terms of the relationship between the pathogenesis and intestinal microbiota.Change of gut microbiota is an important risk factor of the pathogenesis of type 1 diabetes mellitus which have been confirmed with the animal model studies.This article reviews the role of gut microbiota in the pathogenesis of type 1 diabetes mellitus,and the influence of gut microbiota on host immune response for possible prevention and treatment of type 1 diabetes mellitus in the future.

Objective To investigate the effect of recombinant human erythropoietin (rhEPO) on the expression of glutamine synthetase (GS) of cultured rat retinal Müller cells in high glucose environment in vitro.Methods Mtüller cells were isolated from retinas of 10 Sprague-Dawley rats at postnatal day three to five by trypsin digestion,and were randomly divided into six groups,including normal control group,high glucose group,high glucose +5 U/ml rhEPO group,high glucose+ 10 U/ml rhEPO group,high glucose+ 20 U/ml rhEPO group,high glucose+40 U/ml rhEPO groups.After 48 hours,the apoptosis of retinal Müller cells were assayed by terminal transferase-mediated DNA end labelling assay,and the expression levels of GS protein were detected with semi-quantitative immunocytochemistry.Results Compared with the normal control group,the cell viability and GS protein were reduced while the cell death increased in Müller cells cultured in high glucose,the difference was statistically significant (t =27.4,P ＜ 0.01).Compared with the high glucose group,rhEPO treatment reduced the apoptotic Müller cells (t=857.2,2 374.6,2 473.2,2 537.7; P＜0.01),induced the expression of GS proteins (t=3.2,18.0,22.5,26.4; P＜0.05).Conclusions rhEPO can protect Müller cells from apoptosis under high glucose condition.The mechanism may be related to its function to up-regulate the GS protein expression,promote glutamic acid cycle,and reduce the excitotoxicity effects of high concentration of glutamate.