For 10 years recently,China has implemented the strategy of "rejuvenating technology,talents for the first",and China's higher education has made improvement significantly: the number of student in-class increases drastically,the gross enrollment rate of higher education reached the level of popular education.Kunming Medical College,in this particular historical period of development by accelerating the construction and structural adjustment, strengthening management,taping potential,integrating use of resources,has better dealt with the enormous pressure and the challenge caused by the school's operating scale's nearly five times increase,and has ensured the quality of student training;In the new historical period of development, Kunming Medical College will continuously change education ideas,achieve the leap development from teaching university to teaching and research university positively.

Objective: To establish a quantitative method for determination of protocatechuic acid in Xueniao Capsules. Methods: The capsules were extracted with alcohol acetic acid (10∶1) and then solved with absolute alcohol. The sample was applied on a silica H plate, developed and separated in the solution of chloroform acetone methanol acetic acid (7∶2∶1.5∶0.5). The separated spots were determined by TLC scanning at 530nm(? s). Results: The average recovery was 101.4%. Conclusion: This method for determination of protocatechuic acid in Xueniao Capsules was sensitive, accurate and specific. It could be used as quality control for Xueniao Capsules.

The hypo-morality,also known as sub-morality,is an imperfect morality compared with the social mainstream morality.By introducing some "hypo-morality" phenomena in the current physician-patient relationship and analyzing from the two aspects including the diversity of interests main bodies and the market operational mode of healthcare institutions,this paper assures the rationality of the existence of hypo-morality in physician-patient relationship,and attempts to provide feasible suggestions for a reasonable direction of hypo-morality in physician-patient relationship.

The contrast of technical force between hospital and society is astonishing in the maintenance & service of large-scale medical equipment.When the maintenance & service plan must be chosen to socialized service,all the plans must be seriously compared and evaluated according to the current situation of the equipments in hospital for an economical and suitable selection.A right selection is necessary in promoting maintenance and management of large-scale medical equipment,keeping good operation of equipment,prolonging service life,and creating better economic and social benefits.

Objective:To investigate the clinical efficacy ofacupuncture plus Tuina therapy in treating supraspinatus tendinitis.Methods:One hundred patients with supraspinatus tendinitis were randomly allocated to two groups.The treatment group of 50 cases was treated with acupuncture plus Tuina therapy and the control group of 50 cases,with simple acupuncture.Treatment was given once daily,10 times as a course.The therapeutic effects were evaluated after two courses oftreatment.Results:The total efficacy rate was 96.0%in the treatment group and 74.0%in the control group.x2 test showed that there was a statistically significant difference in the total efficacy rate between the two groups(P＜0.01).Conclusion:Acupuncture plus Tuina therapy is superior to simple acupuncture in treating supraspinatus tendinitis.

Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. ?-Synuclein was the first"PD gene"to be discovered. The involvement of ?-synuclein in PD was first suspected after two different ?-synuclein mutations were identified in two kindreds with autosomal-dominant PD. However,the discovery that ?-synuclein is the major component of Lewy bodies-pathological hallmarks of PD, confirmed its role in PD pathogenesis. Pathological aggregation of ?-synuclein might be responsible for neurodegeneration. Multiple factors have been shown to affect ?-synuclein aggregation in vitro or in vivo. In addition, soluble oligomers of ?-synuclein might be even more toxic than the insoluble fibrils found in degenerative diseases. So it is significant to investigate factors affecting ?-synuclein aggregation, especially their accurate effects on the aggregation process.

Objective To investigate the types of commonly used anti-hypertensive drugs and hypoglycemic drugs and treatment schemes to provide a basis for rationally treating hypertension complicating type 2 diabetes mellitus(T2DM).Methods The medication situation in 191 patients with hypertension complicating T2DM in our hospital were analyzed and investigated.The use of anti-hypertensive drugs and hypoglycemic drugs and treatment scheme were statistically analyzed.Results In 191 patients with hypertension complicating T2DM,the single drug use in the anti-hypertensive scheme accounted for 9.42 ％,two-drug combined use accounted for 64.91％,three-drug combined use for 17.8 ％ and four-drug combined use for 7.85 ％.The medication of ARB+CCB had the highest use frequency;the anti-hypertensive total effective rate was 96.86 ％.In the hypoglycemic schemes,the insulin use accounted for 30.37％,and the use frequency of metformin+ gliclazide was highest,the hypoglycemic total effective rate was 98.43％.Conclusion The medication for the patients suffering from hypertension complicating T2DM is relatively reasonable,and worth of being popularized and applied in clinical practice.

Objective Using PBL and CBS pedagogy,to explore the feasibility of the application and effectiveness of teaching in medical genetics teaching. Methods In medical genetics teaching,set the clinical Class 1 grade 2007 to the control group,using traditional pedagogy,set the clinical Class 2 grade 2007 to the experimental group,using PBL and CBS pedagogy. Results Final exam results showed that the experimental group's average scores were significantly higher than control group(P

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with multiple factors involved,and its incidence is gradually increasing around the world.Recent studies have found that gut microbiota is involved in the development and progression of NAFLD.This article summarizes the association between gut microbiota and NAFLD from the aspects of influencing factors for gut microbiota and the roles of gut microbiota and its metabolites in the development and progression of NAFLD and points out that the intervention of gut microbiota and its metabolites may be a new target for the prevention and treatment of NAFLD.

Objective To investigate the effect of Sufentainil on myocardial ischemia-reperfusion injury and caspase-3 to rat heart. Methods Ninety Wistar rats weighing 200-300g were randomly divided into 3 groups(n=30):sham group(group S), ischemia-reperfusion group (group I/R)and Sufentainil group (group SF). Each group was divided into 3 subgroups according to the time phases at 30, 60 and 120min(n=10).In group I/R and group S the animals were received normal saline intravenously. In group SF sufentainil 5μg/kg NS 20ml was given. After 24 h, all animals were anesthetized with intraperitioneal 20% urethane 1 mg/kg, intubated and mechanically ventilated. The chest was opened and heart exposed via thoracotomy.In group S , left artery anterior descending artery(LAD) was not ocluded. While in I/R and SF group myocardial ischemia was introduced by clamping LAD for40 min. The animals were killed at 30, 60 and 120 min of reperfusion respectively(n=10each). Cardiac tropoin I(cTnI), expression of caspase-3 and apoptosis of cell in heart tissues were measured at the same time.Ultrastructure of myocardium taking the from apex was examined by electron microscopy at the end of 120 min reperfusion. Results Compared with group S, the concentration of cTnI was increased in the other 2 groups(P<0.05).cTnI was significantly lower in group SF than in group I/R(P<0.05). Expression of caspase-3 and apoptosis index induced by myocardial reperfusion were attenuatated in group SF(P<0.05). The damage of myocardial ultrastructure caused by myocardial I/R were also significantly improved in group SF. Conclusion Sufentainil may relieve the heart cellular apoptosis by decreasing caspase-3expressing.