After the development of medical informatics and the challenges it is faced were described, the charac-teristic and differential strategies for its development were put forward, including combining electronic information technology with medical informatics practical skills and medical knowledge, training more health information profes-sionals for the society, and improving the overall health information level in our country in order to achieve the sus-tainable development of medical informatics.

Delirium is an acute cerebral disorder syndrome with mean features of fluctuating course,attentional deficits,disorganization of thinking and consciousness change.The biggest difference between delirium and restless is cognitive function.Hypoactive delirium and mixed delirium are usually ignored for their inconspicuous clinic feature,while intensive care unit (ICU) delirium is paid more and more attention by clinicians.Society of Critical Care Medicine (SCCM) IPAD guidance suggests that only recommended prevention of delirium is early mobilization,which the article will further discuss.

Oral and maxillofacial radiology (OMR) in the United States is one of the nine dental specialties recognized by the American Dental Association (ADA). It has a nearly 100-year history of development and has also established a complete set of specialist training system. Staffing, base facilities, financial status, timing of training courses, contents, plans, and goals to be achieved are all clearly defined. All training centers need to undergo regular assessments every seven years with the ADA's Commission on Dental Accreditation (CODA). After graduation, the specialist graduates can be engaged in the clinical teaching and scientific research of radiological diagnosis in universities or general hospitals. They also have the option to open their own business by setting up imaging diagnostic centers or being specialized in tele-radiology to provide imaging diagnosis or consultation report to clinicians in other disciplines, or even assisting in the development of treatment planning for dental implants and orthodontic procedures. Of course, stomatology and OMR education systems are different in China and the United States due to different national conditions. Although the experience in the United States cannot be completely copied, many concepts, standards and goals of OMR specialty training there have been practiced and improved for a long period of time and are worth learning by the Chinese OMR counterparts or relevant agencies.

Objective To confirm the difference in the biological characteristics between V?24 natural killer T cells(NKT) and the cytokine-induced killer cell(CIK).Methods V?24 NKT cells and CIK cells were expanded from human peripheral blood mononuclear cells.Purified TCRV?24~+ NKT cells and CD3~+CD56~+CIK cells were obtained by using Dynal beads.The phenotype and the levels of cytokine and necrosis-related factors expression on the purified NKT cells and CIK cells were determined by flow cytometry.The cytotoxicity of the purified NKT cells and CIK cells were measured by means of DIOC18 staining and flow cytometry.Results The proportions of TCRV?24~+V?11~+NKT cells and CD3~+CD56~+CIK cells were elevated up to 90% after purification.The majority of V?24 NKT cells were CD4~+ and DN NKT cells.They demonstrated high levels of expression of TCRV?24,V?11,CD3 and CD161 and a low level of expression of CD56,but most purified CD3~+CD56~+CIK cells were CD8~+ T cells,with high levels of CD3 and CD56 expression,low level CD161 expression and little TCRV?24 and V?11expression.After antigen stimulation,the purified CD3~+CD56~+CIK cells showed higher levels of expression of IFN-?,TNF-?,Perforin,FasL and TRAIL,compared to the NKT cells.CD3~+CD56~+CIK cells secreted little IL-4,whereas,V?24~+NKT cells secreted high level of IL-4.In addition,the cytotoxic effect of the CD3~+CD56~+CIK cells on tumor cell lines K562,U937 and Jurkat were more intense than that of the NKT cells.Conclusion It is evident that TCRV?24~+ NKT cells and CD3~+CD56~+CIK cells differ absolutely in many ways and might play different roles in anti-tumor immunity and immune regulation.

Stenosis or occlusion of vertebral artery origin is one of important reasons of posterior circulation ischemia. Vertebral artery stenting can reduce posterior circulation ischemia in patients with vertebral artery origin stenosis. Restenosis after stenting is an important reason influencing the long-term efficacy.This article reviews treatment approaches of vertebral artery origin stenosis, restenosis after stenting and the related factors.

Neurological outcome in critically ill neonates has become the focus of attention.Amplitude-integrated electroencephalography (aEEG),as a brain function examination of noninvasive and relatively simple operation,offers a variety of information for pediatricians while early applying to the critically ill newborus,and is helpful to predict the long-term neurological outcome.Currently,the increasing number of neonatal intensive care units are using aEEG as the neurological examination.

We in the present research proposed a classification method that applied infomax independent component analysis (ICA) to respectively extract single modality features of structural magnetic resonance imaging (sMRI) and positron emission tomography (PET). And then we combined these two features by using a method of weight combination. We found that the present method was able to improve the accurate diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Compared AD to healthy controls (HC): the study achieved a classification accuracy of 93.75%, with a sensitivity of 100% and a specificity of 87.64%. Compared MCI to HC: classification accuracy was 89.35%, with a sensitivity of 81.85% and a specificity of 99.36%. The experimental results showed that the bi-modality method performed better than the individual modality in comparison to classification accuracy.
Alzheimer Disease ; diagnosis ; Case-Control Studies ; Cognitive Dysfunction ; diagnosis ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Sensitivity and Specificity

This study is to investigate the effect and its possible mechanisms of lidamycin (LDM) combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human non-small cell lung cancer (NSCLC) cells. MTT assay was used to determine the growth inhibition of the two ingredients on H460 cells. Apoptosis was examined by Annexin V-FITC/PI staining, flow cytometry assay and DNA-specific dye Hoechst 33342 staining. The level of TRAIL receptor and apoptosis-associated protein expression was detected by Western blotting analysis. The results showed that the IC50 value of LDM and TRAIL for H460 cells was 4.603 x 10(-10) mol x L(-1) and 915.3 ng x mL(-1) respectively, but the IC50 value of LDM was 3.064 x 10(-11) mol x L(-1) and 1.611 x 10(-11) mol x L(-1) when different concentrations of LDM was combined with 50 and 100 ng x mL(-1) TRAIL respectively. And the CDI value was less than 1. The apoptosis ratios also increased in the combination group relative to the single-agent treatment and the untreated control. Furthermore, the induction of the cleavage of PARP and the activation of Caspase-3 and Caspase-8 by the combination were more effective than LDM or TRAIL alone. At last, the level of death receptor 5 (DR5) expressions increased in a dose-dependent manner and time-related pattern. The data indicate that LDM inhibits the growth of H460 cells in vitro. DR5 induction contributes to enhancement of TRAIL-induced apoptosis by LDM in human non-small lung cancer cells.

By the traditional Chinese medicine obtaining-pulse equipment coupled with pressure living like flexibility transducer and B-ultrasound scarching unit,collecting demic radial artery signal on cunkou,with the key link of four pulse tracings attributes in term of "position","rate","shape" and "force",each detecting indexes were analyzed synchronically with press pulse wave and ultrasound vas dynamic state changing trendgraph.According to the time lock analysis of electrocardiogram marking method and radial artery pulse wave,the theory approach of pulse tracings digitization were undertaken,and the scores of four attributes on pulse tracings were determined as well.

Objective The change in four parameter of platelets and hemorbeolgy.Methods from 50 ST-segment el- evation acute myocardial infaction(STEMI)patients 50 unstable angina pectoris(UA)patients and 50 normal control (NC)were studied.Results The platelets quantities(PLT)in STEMI Patients and UA patients was lower than in NC(P