Adolescent ; Child ; Humans ; Male ; Nephritis, Interstitial ; pathology ; Uveitis ; pathology

Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Hypertension, Renal ; Infant ; Male ; Retrospective Studies

Aim ToinvestigatewhethertheJAK2/STAT3 signaling pathway regulates prohibitin expres-sion to protect cardiomyocytes against hypoxia/reoxy-genation injury in hydrogen sulfide postconditioning. Methods Primaryculturedcardiomyocytesfromneo-natal rats were divided into 6 groups: control group ( Normal) , hypoxia/reoxygenation group ( H/R ) , hy-drogen sulfide postconditioning group ( NP) , hydrogen sulfide with AG490 group ( N + A ) , AG490 group ( AG) , DMSO group ( DMSO) . The survival percent-age of cardiomyocytes and the release of LDH were tested at pre-hypoxia and reoxygenation 2h. After reox-ygenation, cell apoptosis was detected by flow cytome-try. The expression of t-STAT3, p-SATAT3 and PHB were determined with Western blot analysis. Results No obvious changes were observed among the groups before hypoxia (P <0. 05). After reoxygenation 2h, compared with H/R group, NP group significantly im-proved the survival rate of cardiomyocytes ( P <0. 05 ) , inhibited the release of LDH and the myocardi-al apoptosis ( P <0. 05 ) , meanwhile up-regulated the p-STAT3 and PHB expression. However, AG490 abol-ished the cardioprotection offered by hydrogen sulfide postconditioning and the increase in p-STAT3 and PHB expression.Conclusion Hydrogensulfidepostcondi-tioning may protect cardiomyocytes against hypoxia/reoxygenation injury through the JAK2/STAT3 pathway upregulating the expression of prohibitin.

No abstract available.

Acute Disease ; Adolescent ; Adult ; Aged ; Cyclophosphamide ; administration & dosage ; therapeutic use ; Female ; Hemoperfusion ; Humans ; Male ; Methylprednisolone ; administration & dosage ; therapeutic use ; Middle Aged ; Paraquat ; poisoning ; Renal Dialysis ; Retrospective Studies ; Young Adult

An introduction to the laws applicable to mental disease patients,and the employment and marriage conditions of these patients,revealing the setbacks including low employment rate,low marriage rate and high divorce rate among these people.In this regard,the paper raised the points as follows:Speed up the legislation on mental health laws by the state,enhance mental health law enforcement to protect legitimate righta of mental disease patients; implement of the Law of the Peoples Republic if China on the Protection of Disabled Persons,Regulations on the Employment of the Disabled,to protect and promote equal rights of disabled persons in employment;enhance mental health communicatioas to awake the society in their care and love for mental health and mental disease patients.

The quality and quantity of published SCI papers written by the Third Military Medical University from 2010 to 2012 were analyzed to provide information for the scientific research administration.The problems of assessment with SCI was discussed.At last,suggestions were proposed to improve scientific research administration,innovation ability and scientific and technological level.

Objective To explore the competency of community health administrators in a survey of such administrators at large in Shanghai. Methods McClelland's Competency Dictionary was used to set two benchmark positions, while the behavioral event interviewing and questionnaires were made to survey 19 community health service centers in Shanghai. Results The competency model benchmarking on the head of a medical branch consists of 6 character clusters, 11 characteristic items, 27 evaluation dimensions and 27 typical behavior descriptions. The model benchmarking on the community team leader consists of 5 character clusters, 8 characteristic items, 21 evaluation dimensions and 21 typical behavior descriptions. Conclusion Findings of the survey provide objective criteria for competence appraisal of community health administrators, and serve as reference for formulating their development plans as well.

Objective To investigate the enhancement characteristics of the mass of liver and pancreas on Mn-DPDP enhanced MRI. Methods Mn-DPDP enhanced MRI were carried out in 25 cases, of which 15 cases had examined by Gd-DTPA-enhanced MRI. Conventional plain with SE T 1WI、FSE T 2WI were done in all patient. SE T 1WI and FSPGR T 1WI were performed during 40 minutes～4 hours after the administration of Mn-DPDP, with a dose of 0.5 ml/kg.Parts of the patients were repeat examined 24 hours after the administration of Mn-DPDP. Results Among 10 cases of hepatocelluler carcinoma, slightly heterogeneous enhancement were found in 8 cases.hemi-ring enhancement were found in 2 cases. 2 cases of liver cirrhosis had apparently nodular homogenous enhancement and their signal intensity were higher than normal liver tissue. No enhancement were found in 2 cases of hemangioma, 2 cases of liver metastases and 1 case of hepatic cyst. Also no enhancement were found in 8 cases of pancreatic carcinoma, but the tissue of pancreas around the tumor were enhanced remarkably. Conclusion The Mn- DPDP can show remarkably enhancement of normal liver and pancreas.The medicine's peak value keeps on time grows, can provide plentiful scanning time windows.

Aim To research the protective effect and mechanisms of taurine on myocardial ischemia and reperfusion injury in rats. Methods Myocardial ischemia reperfusion models were established in SD rats. The effects of taurine on the size of myocardial infarction and the changes of activity of SOD , and the levels of MDA and NO in myocardium and plasma of rats with myocardial ischemia and reperfusion injury were observed. Results In rats with myocardial ischemia and reperfusion injury, the taurine could reduce the size of myocardial infarction (P