MiRNA is a class of small endogenous non -coding molecule RNA with regulatory functions , which regulates the target genes at the post -transcriptional level by binding with 3′untranslated regions (3′UTR) specifically.Nuclear factor kappaB(NF-κB)is a kind of significant intranuclear transcription factor .Being activ-ized,it easily combines with the fixed nucleotide sequence in promoter region to initiate gene transcription and participates in the invasion and metastasis of gastric cancer .Recent researches showed that miRNA not only influ-ences on tumor invasion and metastasis by regulating the expression of downstream target gene NF -κB,and itself also could be regulated by NF -κB transcription factors .This essay mainly narrates the expression of microRNA and NF-κB in gastric carcinoma ,and summarize the influence to the invasion and metastasis of gastric cancer cells by regulating thier expression interction .

Objective To assess the feasibility of gastroscopy training with AccuTouch(R) Endoscopy Simulator for novice endoscopists. Methods The novice endoscopists ( n = 8 ) were divided into 2 groups to receive training with the simulator ( group A, n = 4) or with traditional method ( group B, n = 4). After the training, we compared the success rate of independent performance, success rate with aids and failure rate for the first 10 cases between 2 groups. Results There were no significant differences between 2 groups in terms of age, gender, educational background and experience of practice. The group A showed higher independent success rate and success rate with aids, and lower failure rate. Conclusion The simulator, decreasing the learning fees and improving learning efficiency, is applicable to endoscopist training.