After screening,the authors established a mouse model of pathomorphologically special,transplantable mammary spindle cell carcinoma SCC 891 in BALB/c mice.After 48 passages in 2.5 years,the growth of the tumor strain became stable with a 100% transplantibility.Its growth was quite active without observable spontaneous regression.The mean life span of the host mouse was 35.2?7.3 days.BALB/c mice of both sexes and of any age were susceptable to the carcinoma,and the carcinoma was sensitive to various anticancer drugs.

Objective:To investigate the predictive value of triglyceride-glucose (TyG) index for the overall burden of cerebral small vessel disease (CSVD).Methods:Consecutive patients with CSVD admitted to Jiaxing First Hospital from July 2019 to January 2021 were enrolled. MRI was used to conduct the overall burden score of CSVD. The difference of TyG index and other risk factors between high burden group (3-4 points) and low burden group (0-2 points) was analyzed. The independent predictors of the high burden of CSVD were determined by the multivariate logistic regression analysis, and the predictive value of TyG index for the high burden of CSVD was evaluated by the receiver operating characteristic (ROC) curve. Results:A total of 165 patients with CSVD were enrolled, including 103 patients (62.4%) in the low burden group and 62 (37.6%) in the high burden group. The proportion of patients with previous stroke or transient ischemic attack, as well as age, fasting blood glucose, glycosylated hemoglobin and TyG index in the high burden group were significantly higher than those in the low burden group ( P<0.05). Multivariate logistic regression analysis showed that TyG index (odds ratio [ OR] 4.584, 95% confidence interval [ CI] 2.180-8.887; P=0.001) and age ( OR 1.075, 95% CI 1.025-1.128; P=0.003) were the independent predictors of high burden of CSVD. The ROC curve showed that the area under the curve of TyG index for predicting the high burden of CSVD was 0.69 (95% CI 0.60-0.77). The optimal cutoff value was 8.5, and its sensitivity and specificity for predicting the high burden of CSVD were 72.6% and 64.1%, respectively. Conclusion:TyG index is associated with the overall burden of CSVD and has certain predictive value for the high burden of CSVD.