[Objective]This paper sums up professor Wang Xu's experience of differentiating and treating Pidan. [Methods]Through summarizing professor Wang Xu's experience of differentiating and treating principles of prediabetic state, final y we use a case to analyze the specialty of professor Wang Xu's differentiating and treating prediabetic state.[Results]When my teacher deals with the clinical symptoms, she always relegates prediabetic state to Pidan. She establishes the theory from the organ of spleen. In the therapy, she confirms the treatment through trading off among the phlegm, the turbid, the lipid and the stagnated blood. The major therapy is damaging the remaining pathogenesis, replenishing the deficiency, clearing the heat, removing the blood stasis, tradding off al kinds of factors. One sentence summing up is removing the pathological and physiological metabolites generating from the body. Also, she applies the traditional Chinese drugs flexibly which can strengthen the spleen, nourish ying, or adjust the blood according to the deficiency and heat which is more obvious. The most importantly, she suggests the theory that strengthening the spleen can prevent the procession of prediabetic state.[Conclusions] When professor Wang Xu deals with the clinical symptoms, she always relegates prediabetic state to Pidan. And she confirms the therapeutic principles rooting in the spleen. Most of al , the clinical therapeutic effect is notable.