Objective To determine the relationship between brachial-ankle pulse wave velocity(baPWV)and Rho associated coiled coil protein kinase(ROCK)activity with the cardiovascular disease(CVD).Methods 168 patients with CVD were divided in-to the CVD group(123 cases)and the non-CVD group(45 cases)based on the results of coronary angiography.The baPWV value and the ROCK activity were detected.The CVD group were subdivided into the single vessel,double vessels and multiple vessels le-sions groups.Results The baPWV value and ROCK activity in the CVD group were significantly higher than those in the non-CVD group(P<0.05).The more the lesion vessels,the higher the baPWV value(P<0.05).Conclusion The baPWV and ROCK activi-ty are associated with CVD.Therefore,the combined measurement of baPWV and ROCK levels could be used to assess CVD and its risk degree.