OBJECTIVE To describe the clinical features,prognosis and antimicrobial resistance of Enterococcus infection.METHODS We had cultured and identified the bacteria of infected patients with normal methods and tested the resistance of Enterococcus to 6 antimicrobial agents.RESULTS A total of 130 cases of Enterococcus infection were occurred among the severe patients of ICU.Major sources includecl urine,sputum and ascites.A majority of them occurred together with other pathogens and had bad complications.The resistant rate of Enterococcus to penicillin,ampicillin,vancomycin,gentamicin,streptomycin and levofloxacin were 91.5%,23.4%,0,27.0%,32.0% and 24.0%,respectively.The cure rate and mortality attributed to Enterococcus infection after ampicillin,levofloxacin and/or third generation cephalosporins were 63.61% and 11.9%,respectively.The patients infected by Enterococcus and others bacteria together had bad prognosis.CONCLUSIONS The results hint that we should emphasize clinical and laboratory diagnosis to guide the application of antimicrobial agents rightly and improve prognosis.

OBJECTIVE To evaluate the disc diffusion method on the clinical antifungal susceptibility test for yeast-like fungi.METHODS The fluconazole susceptibility test was detected by disc diffusion method and NCCLS broth microdilution method with 113 yeast-like fungus strains isolated from clinical specimens.Three standard strains were used as the quality control.RESULTS The coincidence rate of the two methods was 89.4%.The sensitive strains detected by one method didn′t show resistance in another detection method,and the resistant strains detected by one method yet didn′t show sensitivity in another one.CONCLUSIONS Disc diffusion method can be used in clinical detection instead of NCCLS broth microdilution method.