Objective Statistics the distribution regularity of algae literature in biomedical periodicals written in Chinese. Methods The specialized articles on algae are distributed in 285 types of Chinese periodicals with total 914 articles after retrieving Chinese Biomedical Literature Database(from 1995 to March of 2004). According to Bradford' law and Bradford zone method, three zones are divided into an approximately equal quantity of articles. The zone division is based on the quantity of articles in the periodicals and a digressive sequence as well. Results There are 14 periodicals in the first zone with 308 articles published, which are 4.91% of the total periodicals and 33.7% of the total articles. It could provide the 1/3 information and it is the Core Journals. Conclusion The articles published in Chinese Journal of Marine Drugs are the most, which reaches 90 and occupies 9.8% of the total; therefore, it shall be given priority when alga articles are selected. The scientific comments on periodicals can direct researchers on algae to attain necessary information.

Objectives To study the effect of cooling blood and invigorating circulation method on prevention and treatment of pulmonary fibrosis,and explore its mechanism.Methods Male ICR mice were randomly divided into 4 groups:negative control group,pulmonary fibrosis model group,cooling blood and invigorating circulation group and prednisone positive control group.The pulmonary fibrosis model of mice were established by BLM nasal instillation.After 8 hours,the mice were given prescription of cooling blood and invigorating circulation(Xijiao Dihuang decoction) by gastric perfusion.At the 28th day after treatment,the indexes were detected.The TGF-?1 content of bronchoalveolar lavage fluid(BALF) was tested by enzyme linked immunosorbent assay,and hydroxyproline(HYP) was examined by alkaline hydrolysis.Results The degree of airsacculitis and fibrosis in model group are obviously higher than the negative control group by pathological observation.Compared with model group,HYP content was decreased obviously in herb group(P