Objective To prepare and characterize docetaxel incorporated phosphatidylcholine -sodium desoxycholate mixed micelles (DOX EPC/SDC MMs).Methods Docetaxel mixed micelles (DOX MMs) were prepared using the co-precipitation method .An optimized formulation was obtained by single factor method , which was used to study the effect of several factors on water solubility of DOX in MMs, including EPC/total(EPC+SDC)concentration, total(EPC+SDC) concentration, the pH and ionic strength of the hydrated solution .Then, the obtained DOX MMs were characterized by investigating particle size distribution and morphology , and by conducting dilute experiments to examin micelle stability . Results The EPC/total ( EPC+SDC) concentration ratio was 0.4.The total supplementary material concentration was 2.5%.Pure water was used to disperse the film .The drug loaded MMs had an average size of 18.56 nm and average zeta potential of -24.3 mV.A roundlike shape was observed under a transmission electron microscope ( TEM).Conclusion DOX EPC/SDC MMs, prepared by a simple and convenient method , can enhance water solubility , is physically compatible with injection solutions and is expected to become a new drug delivery system .

Objective To investigate the application effect of APP in continuing care of discharged patients with condylar fracture after operation. Methods By convenience sampling,from September 2016 to March 2017 in a ward of oral and maxillofacial surgery and received surgical treatment of condylar fracture patients 81 cases, randomly divided into observation group (41 cases) and control group (40 cases).On the basis of routine health education,the observation group carried out continuous care by APP, while the control group received routine health education. The opening type, opening degree, occlusion relation and temporomandibular joint pain in two groups were compared at 6 months after discharge. Results The results of 6 months, the patients in the observation group were open type, occlusion and TMJ pain were better than the control group, the opening degree of the observation group was (35.51 ± 4.34) mm, control group was (31.28 ± 4.57) mm, the difference between the two groups was statistically significant(t=-4.28,P<0.05).There was no statistical difference between the two groups of occlusion and temporomandibular joint pain (P>0.05). Conclusions APP can improve the open type, opening and occlusal relation and temporomandibular joint pain in patients with condylar fracture after operation.