1.Reason,trouble and strategy of using true tastiness to mark five flavours of herbs
Yi TANG ; Xuhua QIN ; Rong HU ; Huizhu BAO ; Zulun LI
China Journal of Traditional Chinese Medicine and Pharmacy 2006;0(09):-
The five flavours of traditional Chinese medicine(TCM)stand for five tastes,such as pungent,sweet,sour,bitter and salt.The five flavours not only stand for the actual tastiness of herbs,but also the effect characteristic of TCM according to traditional medical theory.So this kind of situation led to a disorder of the marking standardization of five flavours.So the authors think that we should mark herbs(or TCM)based on their true tastiness,and this way maybe help us to solve the problem and to research the relationship between the flavours and the effect of the herbs(or TCM).
2.A systematic review of intravenous immunoglobulin for critical hand-foot-mouth disease
Shaodong ZHAO ; Jun CHEN ; Xuhua GE ; Yong LIU ; Jun SHI ; Qin ZHANG ; Wenliang YU
Chinese Journal of Applied Clinical Pediatrics 2015;30(22):1716-1720
Objective To evaluate the effectiveness of intravenous immunoglobulin (IVIG) in critical hand-foot-mouth disease (HFMD).Methods The data from PubMed, MEDLINE, EMBASE, EBSChost, Cochrane Library, Cochrane Central Register of Controlled Trials, Ovid, China Biology Medicine disc, Wanfang Data, China National Knowledge Infrastructure, Chinese Citation Database, and other references and grey literatures were retrieved, screening out all those related to clinical trials on treating critical HFMD by IVIG.Standard methods of the Cochrane Collaboration were employed to evaluate the methodological quality of the trials.Meta analysis was performed with Rev man 5.3 software.Results Eleven trials including 967 cases were investigated.The meta analysis showed that IVIG had significantly clinical efficacy (OR =6.84,95% CI:3.74-12.52 ,P < 0.05).IVIG could significantly decrease duration of fever (MD =-1.94,95% CI:-3.07--0.81 ,P <0.05) ,hospitalization time (MD =-4.56,95% CI:-8.95--0.17,P <0.05).There was no significant difference in duration of fever (MD =-0.28,95 % CI:-0.59-0.03, P > 0.05), duration of herpes (MD =0.18,95% CI:-0.22-0.59, P > 0.05), hospitalization time (MD =-0.12,95% CI:-0.47-0.23, P > 0.05) when the dosage of injection was adjusted.Conclusions IVIG is recommended for treating critical HFMD because it is effective in decreasing the duration of fever and hospitalization.Well designed studies with more sample in multi-center are required in further study to explore the efficacy and safety of IVIG on critical HFMD.
3.Correlation study of aspirin resistance and inflammatory factors in patients with coronary heart disease
Qin YU ; Ning ZHU ; Weiyi FANG ; Jianli MAO ; Jianguo ZONG ; Huijun XI ; Xiaopeng JI ; Yan LIU ; Hui WANG ; Xuhua LAN
Chinese Journal of Postgraduates of Medicine 2006;0(16):-
Objective To investigate correlation between aspirin resistance(AR) and inflammatory factors. Methods One hundred and ten patients with coronary heart disease took aspirin 0.1 mg/d for 14 days.It was detected platelet aggregation function induced with adenosine disphosphate (ADP) and arachidonic acid (AA), and investigated correlation between AR and inflammatory factors. Interleukin-1? (IL-1?),interleukin-6 (IL-6) and high sensitive C-reaction protein (hs-CRP) levels. Results IL-6 level of patients with AR was significantly higher than that of aspirin sensitive (AS) patients. The other two index were not different between the two groups. Conclusion IL-6 levels could be used as predictor.
4. Study on the effects of total flavonoids from litchi nucleus on nuclear translocation of nuclear factor-kappa B and related protein expression in rat hepatic stellate cell
Guijin QIN ; Yongzhong ZHAO ; Yanxiu LIU ; Cai LI ; Jie CAO ; Qiuchen CHENG ; Xuhua XIAO ; Qing LU
Chinese Journal of Hepatology 2018;26(7):535-539
Objective:
The effect of total flavonoids of litchi (TFL) on nuclear translocation of nuclear factor-kappa B (NF- kappa B) in rat hepatic stellate cell line (HSC-T6) induced by transforming growth factor - beta 1 (TGF- beta 1) in vitro was studied to explore the mechanism of action of anti-hepatic fibrosis drugs.
Methods:
HSC-T6 was cultured in vitro, induced by TGFβ1 for 24 h, and then treated with TFL at 125, 250 and 500 μg/ml for 48 h. The effect of TFL on NF-κB nuclear translocation in HSC-T6 was observed by confocal laser microscopy. The effects of TFL on the expression of TLR4, p-IκB ɑ, p-NF-κB p65, NF-κB and Collagen I protein were detected by western blot. The expressions of TLR4 and p-NF-κB p65 were detected by immunofluorescence. Data were presented as mean±SEM. Homogeneity test of variance was performed and then followed by one-way analysis of variance (ANOVA). The multiple comparisons between groups were performed by LSD test.