1.Emphasis On the Cultivation of Six Kinds Of Consciousness for Medical Students
Shumei ZHANG ; Huiqing QU ; Xueyu ZHAO ; Chunli LIU
Chinese Medical Ethics 1995;0(02):-
Medical students are the reserves of medical and health service in our country. Strengthening medical students' cultivation and improving their professional quality can play an important role in protecting people's health more efficiently. We must think highly of medical students' duty consciousness, creation consciousness, legal consciousness, problem consciousness, service consciousness and cooperation consciousness.We should enable medical students to have healthy medical professional personality and establish the foundation for the sustainable development of the health care industry of our country.
2.Electronic physiological mechanism of low resistance thought induction psychotherapy(TIP) on depression
Yingna LIN ; Lan HONG ; Yang ZHAO ; Tao LI ; Xueyu LYU ; Guixia LI ; Weidong WANG
International Journal of Traditional Chinese Medicine 2014;36(2):107-109
Objective To observe the electronic physiological mechanism of Low Resistance Thought Induction Psychotherapy (TIP) on depression.Methods 48 patients with depression were randomly divided into TIP group and Citalopram group.The observation period was 6 months.The Hamilton Rating Scale for Depression(HAMD) was used to evaluate the efficacy,and Polysomnogram(PSG)was used to evaluate the electronic physiological mechanism.Results TIP had efficacy on reducing numbers of wake [before treatment (3.92±3.24),after treatment (2.38± 1.21),P<0.05]、REM time [before treatment (86.75 ±28.29),after treatment (63.19±28.11),P<0.01]、REM% [before treatment (23.89±6.84),after treatment (16.16±6.36),P<0.01].Citalopram had efficacy on increasing Sleep time [before treatment (350.52±50.71),after treatment (388.58±43.89),P<0.01]、number of REM [before treatment (3.71±2.87),after treatment (5.17±5.58),P<0.05]、S3+4 [before treatment (35.79±32.76),after treatment (56.77±34.21),P <0.05]、S3 +4% [before treatment (10.13 ± 9.20),after treatment (14.53 ± 8.66),P<0.05]、REM time [before treatment (66.39±29.22),after treatment(78.61 ±30.19),P<0.05].TIP had superior to Citaloprarn on regulating numbers of wake and REM time.Conclusions Electronic physiological mechanism of TIP treating depression is to regulat numbers of wake,REM time,REM%.
3.Content determination of polysaccharides in root of cultivated Glycyrrhiza from different growth time
Jinrong LIU ; Wenbin ZHAO ; Fashou JIANG ; Ying XIANG ; Yun ZHU ; Xiling DENG ; Xueyu LI
Chinese Traditional Patent Medicine 1992;0(06):-
AIM: To measure and compare the content of glycyrrhizic polysaccharides in Glycyrrhiza in three different growth time. METHODS: The contents of polysaccharides were determined by phenol-sulfuric acid method and by reference to glucose, and wavelenth in spectrophotometer was set at 490 nm. RESULTS: There was difference of the content of the extracted polysaccharides among Glycyrrhiza for 1, 2 and 3 year, amounted to 11.75%, 11.07%, 7.88%, respectively. CONCLUSION: Annual glycyrrhiza appeared to be the appropriat crude drug for polysacchrides content. 1.Colle
4.Effects of Celastrus orbiculatus Thunb.Extract on the Overexpression of mTOR in Human HepG2 Cells
Yayun QIAN ; Songhua LU ; Xueyu ZHAO ; Ting YANG ; Youyang SHI ; Feng JIN ; Yanqing LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2016;18(12):2132-2136
This study aimed at investigating the effects of the extract of Chinese herb,Nansheteng (C.orbiculatus Thunb.),on human HepG2 cells through the overexpression of mTOR.The GV238-mTOR recombinant plasmids were transfected into HepG2 cells using molecular biological technology.The expression level of mTOR was evaluated by means of relative activity of luciferase and western blot.Human hepatic carcinoma HepG2/mTOR++ cells were treated with C.orbiculatus extract in different concentrations (20,40,80,160 and 320 tg·mL-1) for 24 h.The mTOR protein expression was detected by western blot.It was found that the protein expression of mTOR in transfected HepG2 cells was significantly enhanced.C.orbiculatus extract significantly inhibited the proliferation of HepG2/mTOR++ cells.Simultaneously,C.orbiculatus extract inhibited mTOR at its protein level in a dose-dependent manner.In conclusion,we successfully constructed recombinant mTOR cloning vectors,and established the stable HepG2 cell line with the overexpression of mTOR.Besides,C.orbiculatus extract significantly inhibited mTOR protein expression in human hepatic carcinoma HepG2 cells.
5.The sleep-improving effect of thought imprint psychotherapy under lower resistant state on depression associated with insomnia
Xueyu Lü ; Yingna LIN ; Lan HONG ; Fang WANG ; Yang ZHAO ; Weidong WANG
International Journal of Traditional Chinese Medicine 2012;34(1):8-10
ObjectiveTo study the effect of thought imprint psychotherapy in lower resistant state (a TCM psychotherapy ) treating insomnia accompanied by depression.MethodsIntervened patients by sleep regulating technique of lower resistant state for 6 months.PSQI and PSG were tested prior and post treatment.ResultsThe data from PSQI and PSG indicated the improvement of their sleep quality:PSQI:sleep quality (2.500±0.589) vs (1.416±0.928),initiating sleep time(2.375±0.875) vs (1.416±0.880),sleep time (2.125±0.947) vs (1.500±0.884),sleep efficiency (1.625±1.135) vs (0.958±0.954),sleep disorder (1.875±0.536)vs (1.416±0.775),daytime function (2.416±0.880) vs (1.833± 1.203); PSG:sleep efficiency (0.82±0.11)% vs (0.88±0.10)%,number of wake (3.92±3.24) vs (2.38±1.21),stage 1 percentage (27.4±11.9)%vs (23.5±7.8)%,stage 3 percentage (10.2±6.8) % vs (15.6±5.9)%,REM sleep percentage (23.89±6.84) % vs (16.16 ± 6.36) %,P<0.05 or 0.01.ConclusionSleep regulating technique in lower resistant state can improve patients' sleep quality.
6.HPLC fingerprint of Euodiae Fructus.
Ping ZHAO ; Haiyu XU ; Jun XU ; Tiejun ZHANG ; Xueyu ZHU
China Journal of Chinese Materia Medica 2010;35(23):3178-3183
OBJECTIVETo establish a HPLC fingerprint for quality evaluation of fructus Euodiae rutaecarpa, and to perform qualitative and quantitative analysis of its main constituents.
METHODThe 10 batches of samples were analyzed by HPLC linear gradient elution method and evaluated by similarity evaluation and system cluster analysis. The common peaks in chromatographic fingerprint were identified by LC-DAD-MS.
RESULTThe HPLC fingerprint of Euodiae Fructus showed 32 characteristic peaks, among them 13 peaks were identified, and 2 constituents were quantified.
CONCLUSIONThe HPLC fingerprint established could reflect the main constituents of Euodiae Fructus, and could combine with content determination to take an overall control of Euodiae Fructus.
Chromatography, High Pressure Liquid ; methods ; Drugs, Chinese Herbal ; analysis ; Evodia ; chemistry
7.Applied anatomy of the first plantar lumbrical muscle
Yun TANG ; Zehua ZHENG ; Miaomiao CUI ; Xueyu SUN ; Xinyue ZHAO ; Miao YU ; Xiangzheng QIN
Chinese Journal of Microsurgery 2018;41(2):166-168
Objective To investigate the anatomical structure of the first plantar lumbrical muscle in the foot and to measure the relevant data which could provide anatomical basis for repairing thumb and finger defects with the transplantation of toes accompanied with the first lumbrical muscle,and to explore the marphological function of the first lumbrical muscle of the foot.Methods From March,2016 to January,2018,a systematic and detailed dissection of the 50 formalin-fixed feet was performed to observe the exact position of the starting and ending points of the first lumbrical muscle,and a Vernier caloper was used to measure the relevant record data.Results The first lumbrical muscle originates from the medial portion of the flexor digitorum lungus tendon of the second toe,and the length of the ventral muscle was [55.87±8.67(79.30-41.16] mm.There were 2 endpoints in the tendon.The first one was in the medial tubercle of the proximal phalanges.The second one was aponeurosis of the dorsal toe and the tendon was divided into proximal and distal segments with the medial tubercle as the mark point.The length of the proximal segment was [15.34±4.81(5.52-25.18] mm,the width of the proximal segment was [2.31±1.12(3.28-1.21)] mm,the thickness was [0.44±0.14(0.28-0.68)] mm;the length of the distal segment was [11.51±4.06(3.46-14.90)] mm,the width was [6.10±1.44(9.36-3.70)] mm,and the thickness was [0.18±0.09(1.10-0.38)] mm.The length and thickness of the proximal segment was signifantly larger than those of the distal segment (P<0.05).Conclusion The first lumbrical muscle has the function of maintaining the balance and stability of both the toe and the arch during movement,flexuring the metatarsophalangeal joint,extending the interosseous joint of the extensor phalangeal,adducting the second toe;also the function of preventing the second toe from pronation during foots' movement.
8.The early use of iNO in extremely premature neonates with refractory hypoxic respiratory failure
Yongping FU ; Xueyu CHEN ; Haifeng ZONG ; Jie ZHAO ; Hui TANG ; Zhifeng HUANG ; Chuanzhong YANG
Chinese Journal of Neonatology 2023;38(3):166-170
Objective:To study the early use of inhaled nitric oxide (iNO) as a rescue therapy in extremely premature infants (EPIs) with refractory hypoxic respiratory failure (HRF).Methods:Between January 2021 and December 2021, EPIs with refractory HRF receiving iNO within the first week of life in our NICU were enrolled. Their clinical characteristics and outcomes were retrospectively analyzed.Results:A total of 11 EPIs were included with 5 males and 6 females. The median gestational age (GA) was 24(22.6, 25.2) weeks. The median birth weight (BW) was 580(490, 770) g. The most common primary diagnoses were moderate/severe respiratory distress syndrome (RDS) (5/11) and early-onset sepsis (3/11). The median age starting iNO therapy was 6.5(4.5, 34.0)h and the median duration of iNO was 24(12, 36)h. The median iNO starting dose was 5(5, 8) ppm and the therapeutic range was 5-20 ppm. Therapeutic efficacy was defined as ≥30% FiO 2 reduction after 6 h of iNO treatment. The treatment was effective in 8 cases. The oxygenation index (OI) decreased more than 10% from baseline 1 h after initiation in 9 patients and in all 11 patients after 12 h of iNO. The reduction of OI was more prominent in EPIs with a higher OI at baseline. Of the 11 patients, 8 survived, 1 died and 2 abandoned further treatments. Conclusions:As an early rescue therapy for EPIs with refractory HRF, iNO can improve oxygenation without obvious short-term adverse effects.
9. Association between long-term blood pressure change and the incidence of cardiovascular diseases: a population-based cohort study
Xueyu HAN ; Yue QI ; Dong ZHAO ; Wei WANG ; Miao WANG ; Jiayi SUN ; Jun LIU ; Yan LI ; Jing LIU
Chinese Journal of Cardiology 2018;46(9):695-700
Objective:
To explore the association between long-term changes in blood pressure (BP) levels and the incidence of cardiovascular diseases (CVD).
Methods:
A total of 5 752 participants, who participated baseline examination in 1992-1993 and re-examination in 2007, were followed up till December 31, 2013 according to the study protocol of the Chinese Multi-provincial Cohort Study. Participants were stratified by baseline BP and re-examination BP and cross-combined into 9 subgroups. The 20-year incidence of acute cardiovascular events, acute coronary heart disease (CHD) and acute stroke events were analyzed and association between disease incidence and 15-year changes in BP were determined using the competing risk regression model.
Results:
(1) There were 523 CVD events (170 CHD, 373 stroke) during the 20 years follow up. The number of participants with baseline systolic blood pressure (SBP)/diastolic blood pressure (DBP) of <130/80 mmHg (1 mmHg=0.133 kPa), 130-139/80-89 mmHg, and hypertension were 2 892 (50.3%), 1 328 (23.1%) and 1 532 (26.6%), respectively. (2) Among participants with baseline SBP of 130-139 mmHg or DBP of 80-89 mmHg, 870 (65.5%) progressed to hypertension and 279 (21.0%) maintained at the same stratum over a 15-year follow up period. (3) After adjustment for age, sex, body mass index, smoking status, diabetes, total cholesterol, and high-density lipoprotein cholesterol at baseline, participants maintained SBP/DBP at 130-139/80-89 mmHg had a higher risk of developing acute cardiovascular events, CHD and stroke with the hazard ratios (