Objective To assess the diagnostic value in breast nodules with ultrasontic scoring.Methods Benign and malignant breast nodules were studied with ultrasonic scoring and compared with pathologic results.Results The 2D-ultra-sontic scoring and total ultrasontic scores of benign breast nodular lesions had significant difference compared to malignant breast nodular lesions (P<0.01).Ultrasontic scores of malignant breast nodular lesions were higher than those of benign breast nodular lesions (P<0.01).According to the ROC curve and Youden index,2D-ultrasonic scores ≥11 could be considered as the critical point for the diagnosis of malignant breast nodular lesions,the total ultrasonic scores ≥12 could be considered as the critical point for diagnosis of malignant breast nodular lesions.Conclusion Ultrasonic scoring for breast nodular lesions may be useful for improving the diagnosis accuracy of the benign and malignant breast nodular lesions.