1.Antiasthmatic Effect of Mabuterol in Guinea Pigs
Xueya WANG ; Meihui WANG ; Ji'An GUO ;
China Pharmacy 1991;0(05):-
OBJECTIVE:To study the antiasthmatic effect of Mabuterol in guinea pigs.METHODS:Severe dyspnea was induced by2%acetylcholine and0.1%histamine solution in conscious guinea pigs.RESULTS:Experiment showed that Mabuterol could significantly inhibit the experimental asthma induced by mixture of2%acetylcholine and0.1%histamine solution in conscious guinea pigs.It also significantly prolonged the latency of induced asthma and decreased the number of guinea pigs on twitches induced by asthma.Bronchodilating effect of Mabuterol was in a dose-dependent manner.The ED 50 of Mabuterol was0.2mg/kg and95%confidence limit was0.08~0.49mg/kg.CONCLUSION:In comparison with salbutanmol,Mabuterol is longer in duration and more potent in action of bronchodilatation.
2.Relationship between hs-c-reactive protein and severity of coronary artery disease
Xueya GUO ; Hao HU ; Feng ZHAO ; Jing YU ; Bin ZHANG
Chinese Journal of Postgraduates of Medicine 2006;0(13):-
Objective To investigate the relationship between the hs-c-reactive protein and the severity of coronary artery disease.Methods All the 67 patients underwent coronary angiography and measured risk factors,the Gensini score was used to determine the results of the coronary angiography.The t test,One-Way ANOVA and multiple linear regression analysis were used to predict hs-CRP.Results Coronary artery disease group hs-CRP levels were significantly higher than those in non-coronary artery disease group(P
3.Fingolimod hydrochloride suppresses inflammatory reaction of blood vessels after balloon injury of the carotid artery
Liang LIU ; Feng BAI ; Shougang SUN ; Guangli XU ; Hao HU ; Xueya GUO
Chinese Journal of Tissue Engineering Research 2014;(11):1712-1717
BACKGROUND:Inflammatory factor plays an important role in restenosis after bal oon injury. Sphingosine1-phosphate receptor 1 can enhance the expression of inflammatory factor and promote development and progression of this pathological process.
OBJECTIVE:To observe the expression of the inflammatory factors and sphingosine1-phosphate receptor 1 after bal oon injury of the rat carotid artery and effects of fingolimod hydrochloride on reducing inflammatory reaction.
METHODS:Sixty Sprague-Dawley rats were equal y and randomly divided into four groups. In the blank control group and negative control group, left common carotid artery was only isolated, and left external carotid artery was ligated. In the bal oon injury group and drug intervention group, rat models of carotid artery injury were
established by bal oon injury on the left common carotid artery. In the negative control and drug intervention groups, the rats were intraperitoneal y injected with fingolimod hydrochloride 1 mg/kg. In the blank control and bal oon injury groups, the rats were intraperitoneal y injected with an equal volume of saline. Samples were col ected at 3, 7 and 21 days.
RESULTS AND CONCLUSION: Hematoxylin-eosin staining showed that the proliferation of blood vessel was remarkable in the bal oon injury group, but attenuated in the drug intervention group. The appearance of blood vessels was normal in the blank control group and negative control group. Real-time fluorescent quantitative PCR revealed that cyclooxygenase 2 and prostaglandin E2 mRNA expression levels were significantly lower in the drug intervention group than those in the bal oon injury group at 7 days (P<0.05). Cyclooxygenase 2 and prostaglandin E2 mRNA expression levels were significantly higher in the bal oon injury group and drug intervention group than those in the blank control group and negative control group at the same time point (P<0.05). Western blot assay results revealed that sphingosine1-phosphate receptor 1 expression was high in early stage of injury, and then reduced in late stage of injury. In particular, protein expression further decreased after drug intervention. Results indicated that fingolimod hydrochloride suppressed inflammatory reaction of injured blood vessels and lessened the stenosis of injured blood vessels by regulating cyclooxygenase 2 and prostaglandin E2 mRNA expression using sphingosine1-phosphate receptor 1.
4.First Case of Transformation of Immunoglobulin Heavy Chain Variable-Mutated Chronic Lymphocytic Leukemia Into Chronic Myeloid Leukemia
Annals of Laboratory Medicine 2019;39(6):577-579
No abstract available.
Immunoglobulin Heavy Chains
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Immunoglobulins
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Leukemia, Lymphocytic, Chronic, B-Cell
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive